Format:
Online Ressource (xiii, 577, [23] p. of plates)
,
col. ill.
Edition:
1st ed.
Edition:
Online-Ausg.
ISBN:
9780123884152
,
0123884152
,
1283735032
,
9781283735032
Content:
Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usageSide-by-side coverage of the basis of epigenetic diseases and their treatmentsEvaluation of recent epigenetic clinical breakthroughs
Note:
Includes bibliographical references and index. - Description based on title from publisher's website (ScienceDirect, viewed on June 25, 2012)
,
Front Cover; Epigenetics in Human Disease; Copyright; Contents; Preface; Contributors; Chapter 1 - Epigenetics of Human Disease; 1.1 INTRODUCTION; 1.2 EPIGENETIC VARIATION METHODS; 1.3 CANCER EPIGENETICS; 1.4 EPIGENETICS OF NEUROLOGICAL DISEASE; 1.5 AUTOIMMUNITY AND EPIGENETICS; 1.6 HUMAN IMPRINTING DISORDERS; 1.7 EPIGENETICS OF OBESITY; 1.8 DIABETES: THE EPIGENETIC CONNECTION; 1.9 EPIGENETICS AND ALLERGIC DISORDERS; 1.10 CARDIOVASCULAR DISEASE AND EPIGENETICS; 1.11 EPIGENETICS OF HUMAN INFECTIOUS DISEASES; 1.12 REPRODUCTIVE DISORDERS AND EPIGENETIC ABERRATIONS
,
1.13 STEM CELL EPIGENETICS IN HUMAN DISEASE1.14 EPIGENETICS OF AGING AND AGE-ASSOCIATED DISEASES; 1.15 CONCLUSION; References; Chapter 2 - Methods and Strategies to Determine Epigenetic Variation in Human Disease; 2.1 INTRODUCTION; 2.2 DNA METHYLATION ANALYSIS; 2.3 HISTONE MODIFICATION ANALYSIS; 2.4 NON-CODING RNA ANALYSIS: MICRORNA; 2.5 ANALYSIS OF GENOME DNA REPLICATION PROGRAM BASED ON DNA REPLICATION TIMING; 2.6 STRATEGY FOR EPIGENOMIC INVESTIGATION BASED ON CHROMOSOMAL BAND STRUCTURES; 2.7 OVERVIEW OF RECENT EPIGENETIC GENOME-WIDE OR BIOINFORMATIC STUDIES AND STRATEGIES
,
2.8 GENERAL OVERVIEW AND FUTURE PERSPECTIVEReferences; Chapter 3 - DNA Methylation Alterations in Human Cancers; 3.1 INTRODUCTION: BIOLOGICAL ROLES OF DNA METHYLATION; 3.2 DNA METHYLATION ALTERATIONS IN HUMAN CANCERS; 3.3 ABERRANT DNA METHYLATION IN PRECANCEROUS CONDITIONS ASSOCIATED WITH CHRONIC INFLAMMATION, PERSISTENT VIRAL INFE ...; 3.4 ABNORMAL EXPRESSION OF DNMTS IN HUMAN CANCERS; 3.5 MUTATIONS, POLYMORPHISM AND SPLICING ALTERATIONS OF DNMTS AND HUMAN CANCERS; 3.6 SIGNAL PATHWAYS AFFECTING DNA METHYLATION STATUS DURING TUMORIGENESIS; 3.7 DNA METHYLATION AND HISTONE MODIFICATIONS
,
3.8 SUBCLASSIFICATION OF HUMAN CANCERS BASED ON DNA METHYLATION PROFILING3.9 DIAGNOSIS OF CANCERS IN BODY FLUIDS AND BIOPSY SPECIMENS BASED ON DNA METHYLATION PROFILES; 3.10 CARCINOGENETIC RISK ESTIMATION BASED ON DNA METHYLATION PROFILES; 3.11 PERSONALIZED MEDICINE BASED ON DNA METHYLATION PROFILES: PROGNOSTICATION OF PATIENTS WITH CANCERS AND PREDICT ...; 3.12 NEW TECHNOLOGIES FOR DNA METHYLATION ANALYSIS AND FUTURE DIRECTIONS; References; 4 - Alterations of Histone Modifications in Cancer; 4.1 INTRODUCTION; 4.2 CHROMATIN ORGANIZATION; 4.3 HISTONE MODIFICATIONS
,
4.4 HISTONE MODIFICATIONS AND CANCER4.5 MECHANISMS UNDERLYING HISTONE ALTERATIONS IN CANCER; 4.6 CONCLUSIONS; References; 5 - MicroRNA in Oncogenesis; 5.1 INTRODUCTION; 5.2 MIRNA BIOGENESIS; 5.3 MIRNA-MEDIATED REGULATION OF TARGETS; 5.4 MIRNA AND CANCER; 5.5 ONCOMIRS; 5.6 MECHANISMS OF MIRNA DEREGULATION; 5.7 MIRNA AND TREATMENT RESISTANCE; 5.8 CLINICAL APPLICATIONS; References; 6 - Epigenetic Approaches to Cancer Therapy; 6.1 INTRODUCTION; 6.2 HISTONE ACETYLATION; 6.3 HISTONE DEACETYLASES; 6.4 HISTONE METHYLATION AND DEMETHYLATION; 6.5 DNA METHYLATION; 6.6 ACETYLATION OF NON-HISTONE PROTEINS
,
6.7 FUTURE DIRECTIONS
,
Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usageSide-by-side coverage of the basis of epigenetic diseases and their treatmentsEvaluation of recent epigenetic clinical breakthroughs
Additional Edition:
ISBN 1283735032
Additional Edition:
Printausg. Epigenetics in human disease London [u.a.] : Academic Press, 2012 ISBN 0123884152
Additional Edition:
ISBN 9780123884152
Language:
English
Subjects:
Biology
Keywords:
Epigenetik
;
Humangenetik
;
Electronic books
;
Electronic books
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