UID:
almahu_9948026435302882
Format:
1 online resource (349 p.)
ISBN:
1-283-09229-8
,
9786613092298
,
0-12-388424-1
Content:
One of the most pressing tasks in biotechnology today is to unlock the function of each of the thousands of new genes identified every day. Scientists do this by analyzing and interpreting proteins, which are considered the task force of a gene. This single source reference covers all aspects of proteins, explaining fundamentals, synthesizing the latest literature, and demonstrating the most important bioinformatics tools available today for protein analysis, interpretation and prediction. Students and researchers of biotechnology, bioinformatics, proteomics, protein engineering, biophysics
Note:
Description based upon print version of record.
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Front cover; Protein Bioinformatics: From Sequence to Function; Copyright page; Contents; Foreword; Preface; Acknowledgments; Chapter 1: Proteins; 1.1 Building blocks; 1.2 Hierarchical representation of proteins; 1.3 Structural classification of proteins; 1.4 Databases for protein sequences; 1.5 Protein structure databases; 1.6 Literature databases; 1.7 Exercises; References; Chapter 2: Protein Sequence Analysis; 2.1 Sequence alignment; 2.2 Programs for aligning sequences; 2.3 Amino acid properties; 2.4 Amphipathic character of a-helices and ß-strands
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2.5 Amino acid properties for sequence analysis2.6 Exercises; References; Chapter 3: Protein Structure Analysis; 3.1 Assignment of secondary structures; 3.2 Computation of solvent accessibility; 3.3 Representation of solvent accessibility; 3.4 Residue-residue contacts; 3.5 Amino acid clusters in protein structures; 3.6 Contact potentials; 3.7 Cation-p interactions in protein structures; 3.8 Noncanonical interactions; 3.9 Free energy calculations; 3.10 Amino acid properties derived from protein structural data; 3.11 Parameters for proteins; 3.12 Protein structure comparison; 3.13 Exercises
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ReferencesChapter 4: Protein Folding Kinetics; 4.1 ?-value analysis; 4.2 Folding nuclei and ?-values; 4.3 Relationship between amino acid properties and ?-values; 4.4 ?-value analysis with hydrophobic clusters and long-range contact networks; 4.5 Kinetic database for proteins; 4.6 Prediction of protein folding rates; 4.7 Relationship between ?-values and folding rates; 4.8 Exercises; References; Chapter 5: Protein Structure Prediction; 5.1 Protein structural class; 5.2 Secondary structure content; 5.3 Secondary structural regions
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5.4 Discrimination of transmembrane helical proteins and predicting their membrane-spanning segments5.5 Discrimination of transmembrane strand proteins; 5.6 Identification of membrane-spanning ß-strand segments; 5.7 Discrimination of disordered proteins and domains; 5.8 Solvent accessibility; 5.9 Inter-residue contact prediction; 5.10 Protein tertiary structure prediction; 5.11 Exercises; References; Chapter 6: Protein Stability; 6.1 Determination of protein stability; 6.2 Thermodynamic database for proteins and mutants
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6.3 Relative contribution of noncovalent interactions to protein stability6.4 Stability of thermophilic proteins; 6.5 Analysis and prediction of protein mutant stability; 6.6 Exercises; References; Chapter 7: Protein Interactions; 7.1 Protein-protein interactions; 7.2 Protein-DNA interactions; 7.3 Protein-RNA interactions; 7.4 Protein-ligand interactions; 7.5 Quantitative structure activity relationship in protein-ligand interactions; 7.6 Exercises; References; Appendix A; List of protein databases; List of protein Web servers; Index
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English
Additional Edition:
ISBN 81-312-2297-7
Language:
English
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