UID:
almahu_9949982625402882
Umfang:
1 online resource (xi, 501 pages) :
,
illustrations
Ausgabe:
First edition.
ISBN:
9780124078284
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0124078281
Serie:
Gale eBooks
Inhalt:
Volumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. This organizational structure meets the needs of the pharmaceutical community and allows for the development of a timely vehicle for publishing review materials on this topic. The scope of the Profiles series encompasses review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substa
Anmerkung:
"ISSN: 1871-5125 (Series)."
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Front Cover; Profiles of Drug Substances, Excipients, and Related Methodology; Copyright; Contents; Preface; Chapter One: Alendronate Sodium; 1. General Information; 1.1. Nomenclature; 1.1.1. Systematic chemical name; 1.1.2. Nonproprietary names; 1.1.3. Proprietary names; 1.2. Formulae (Tables1.1 and 1.2); 1.3. Elemental analysis; 1.4. Appearance; 2. Physical Profile; 2.1. Dissociation constants (Alendronic acid) (Figure 1.1 and Table 1.3); 2.2. Solubility characteristics; 2.3. Partition and distribution coefficients; 2.4. Crystallographic properties and polymorphism
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2.4.1. Single-crystal structure2.4.2. Powder X-ray diffraction (PXRD); 2.5. Hygroscopicity; 2.6. Thermal methods of analysis; 2.7. Spectroscopy; 2.7.1. UV spectroscopy; 2.7.2. Vibrational spectroscopy; 2.7.3. Nuclear magnetic resonance spectroscopy; 2.7.4. Mass spectrometry; 3. Stability; 4. Methods of Chemical Synthesis; 5. Analytical Profile; 5.1. Impurities of Alendronate sodium; 5.2. Compendial tests; 5.3. Noncompendial analytical methods; 5.4. Analysis in biological matrices; 6. ADME; 6.1. Absorption; 6.2. Distribution; 6.3. Metabolism; 6.4. Elimination; Acknowledgments; References
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Chapter Two: Aripiprazole1. General Information; 1.1. Solubility; 1.2. Chemical name; 1.3. Synonym; 1.4. CAS number; 1.5. pKa and coefficient partition; 1.6. Proprietary preparations; 1.7. Structural formula; 1.8. Molecular formula, molecular weight, and elementary analysis; 2. Polymorph and Solvatomorphs; 3. Impurities and Degradation Products; 4. Spectroscopy; 4.1. UV spectroscopy; 4.2. Vibrational spectroscopy; 4.3. Nuclear magnetic resonance spectroscopy; 4.4. Mass spectrometry; 5. Method of Analysis; 5.1. Spectrophotometer; 5.2. High-performance liquid chromatography
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5.3. Thin-layer chromatography5.4. Capillary electrophoresis; 6. Metabolite Studies and Bioanalysis; 7. Concluding Remarks; References; Chapter Three: Butyl Methoxy Dibenzoylmethane; 1. General Information; 1.1. Nomenclature; 1.1.1. INCI name; 1.1.2. IUPAC name; 1.1.3. Other names, trade names, abbreviations; 1.2. Formulae; 1.2.1. Empirical formula, molecular weight, and CAS number [1]; 1.2.2. Structural formulae; 1.3. Elemental analysis; 1.4. Appearance; 2. Use and Mechanism of Action; 3. Method of Preparation; 4. Physical Characteristics; 4.1. Melting range
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4.2. Differential scanning calorimetry4.3. Partition coefficient; 4.4. Ionization constant; 4.5. Solubility; 4.6. Spectrometry; 4.6.1. UV spectrometry; 4.6.2. Infrared spectrometry; 4.6.3. NMR spectrometry; 4.6.3.1. 1H NMR spectrometry; 4.6.3.2. 13C NMR spectrometry; 4.6.4. Mass spectrometry; 4.7. X-Ray powder diffraction pattern; 5. Methods of Analysis; 5.1. U.S. pharmacopeial methods [11]; 5.1.1. Identification; 5.1.2. Melting range, Class I (741); 5.1.3. Loss on drying (731); 5.1.4. Chromatographic purity; 5.1.5. Assay: Gas chromatographic analysis; 5.2. Chromatographic methods
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5.2.1. Gas chromatography
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English
Weitere Ausg.:
ISBN 9780124076914
Weitere Ausg.:
ISBN 0124076912
Sprache:
Englisch
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