UID:
almafu_9959233135002883
Umfang:
1 online resource (375 p.)
ISBN:
1-281-05704-5
,
9786611057046
,
0-08-053598-4
Serie:
Biology of Extracellular Matrix
Inhalt:
The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases, and provide information on the latest strategies to inhibit enzyme activity. This work will be an indispensable reference tool for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, developmental biology, pathology, and therapeutic interventions.Key Features* Provides state-of-the-art information on a field with broad implications to many areas of biology* Includes detailed coverage of the stru
Anmerkung:
Description based upon print version of record.
,
Front Cover; Matrix Metalloproteinases; Copyright Page; Contents; Contributors; Preface; Chapter 1. The Matrix Metalloproteinase Family; I. Introduction; II. The Position of MMPs within the Class of Metalloproteases; III . The Matrixin Subfamily; IV. The Domain Structure of the Matrixins; V. The Biological Role of the Matrixins; VI. What the Future Might Hold; References; Chapter 2. Interstitial Collagenases; I. Introduction; II. Matrix Metalloproteinase - 1: The Original Interstitial Collagenase; III ."" Nontraditional "" Interstitial Collagenases; IV. Summary and Future Perspectives
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ReferencesChapter 3. Stromelysins 1 and 2; I. Introduction; II. Structure and Substrate Specificity; III . Activation Mechanisms; IV. Inhibitors; V. Regulation of Gene Expression; VI. Biological and Pathological Roles; VII. Conclusions and Future Prospects; References; Chapter 4. 72-kDa Gelatinase (Gelatinase A): Structure, Activation, Regulation, and Substrate Specificity; I. Introduction; II. Matrix Metalloproteinase Family; III. Multilevel Regulation of Gelatinase A; IV. Substrate Specificity; V. Role of Gelatinase A in Cellular Processes; VI. Role of Gelatinase A in Platelet Aggregation
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VII. PerspectivesReferences; Chapter 5. Gelatinase B: Structure, Regulation, and Function; I. Introduction; II. Gene Structure; III. Protein Structure and Activation; IV. Substrates and Inhibitors; V. Regulation of Expression; VI. Function; VII. Conclusion and Future Directions; References; Chapter 6. Matrilysin; I. Introduction; II. Amino Acid Sequence and Gene Organization; III. Regulation of Expression; IV. Protein Structure and Proteolytic Activities; V. Expression in Cancer and Other Diseases; VI. Role in Normal Tissue Remodeling and Homeostasis; VII. Summary and Concluding Remarks
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ReferencesChapter 7. Macrophage Elastase (MMP-12); I. Introduction; II. The Gene for Macrophage Elastase and Its Expression; III. Activation and Processing; IV. Protein Preparation; V. Catalytic Features; VI. Inhibition; VII. Biological Aspects; VIII. Summary; References; Chapter 8. Membrane-Type Matrix Metalloproteinases and Cell Surface- Associated Activation Cascades for Matrix Metalloproteinases; I. Introduction; II. Potential Activation Routes for Matrix Metalloproteinases; III. Structure of Membrane-Type Matrix Metalloproteinases
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IV. Cellular Sources of MT-MMPs and Regulation of ExpressionV. Activation of MT-MMPs; VI. Activation of Progelatinase A by MT1-MMP and MT2-MMP; VII. Activation of Procollagenase-3 by MT1-MMP; VIII. Substrate Specificity of MT-MMPs; IX. Summary; References; Chapter 9. Substrate Specificity and Mechanisms of Substrate Recognition of the Matrix Metalloproteinases; I. Introduction; II. Peptide Sequence Specificity; III. Protein Substrate Specificity; IV. Mechanisms of Substrate Recognition; References; Chapter 10. Synthetic Inhibitors of Matrix Metalloproteinases; I. Introduction
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II. Design of Synthetic Inhibitors
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English
Weitere Ausg.:
ISBN 0-12-545090-7
Sprache:
Englisch
Schlagwort(e):
Electronic books.
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