UID:
almafu_9958130912502883
Umfang:
1 online resource (437 p.)
ISBN:
0-08-057123-9
Inhalt:
This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered!n Emphasizes the use of the principles of physical organic chemistry as a basis for drug designn Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemesn Uses figures
Anmerkung:
Description based upon print version of record.
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Front Cover; The Organic Chemistry of Drug Design and Drug Action; Copyright Page; Dedication; Table of Contents; Preface; Chapter 1. Introduction; I. Medicinal Chemistry Folklore; II. Discovery of New Drugs; References; General References; Chapter 2. Drug Discovery, Design, and Development; I. Drug Discovery; II. Drug Development: Lead Modification; References; General References; Chapter 3. Receptors; I. Introduction; II. Receptor Structure; III. Drug-Receptor Interactions; References; General References; Chapter 4. Enzymes (Catalytic Receptors); I. Enzymes as Catalysts
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II. Mechanisms of Enzyme CatalysisIII. Coenzyme Catalysis; IV. Enzyme Therapy; References; General References; Chapter 5. Enzyme Inhibition and Inactivation; I. Why Inhibit an Enzyme?; II. Drug Resistance; III. Drug Synergism (Drug Combination); IV. Reversible Enzyme Inhibitors; V. Irreversible Enzyme Inhibitors; References; General References; Chapter 6. DNA; I. Introduction; II. DNA Structure and Properties; III. Classes of Drugs That Interact with DNA; IV. Epilogue to Receptor-Interactive Agents; References; General References; Chapter 7. Drug Metabolism; I. Introduction
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II. Synthesis of Radioactive CompoundsIII. Analytical Methods in Drug Metabolism; IV. Pathways for Drug Deactivation and Elimination; References; General References; Chapter 8. Prodrugs and Drug Delivery Systems; I. Enzyme Activation of Drugs; II. Mechanisms of Prodrug Activation; References; General References; Index
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English
Weitere Ausg.:
ISBN 0-12-643730-0
Sprache:
Englisch
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