Kooperativer Bibliotheksverbund

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Umfang: 1 online resource (562 p.)

ISBN: 9780128016725 , 0128016728

Inhalt: "The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or conversely promote the health of the offspring. This book mines the existing literature of a variety of disciplines, from toxicology to nutrition to epigenetics, to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother's diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, and neurobehavioral disorders, and increased risk of cancer, to list but a few examples. Importantly, the common thread of how in utero and postnatal environmental changes may lead to DOHaD effects is through various epigenetic changes. The Epigenome and Developmental Origins of Health and Disease is a unique resource not only for geneticists and epigeneticists, but also for toxicologists, obestetricians, gynecologists, neurobiologists, nutritionists, physiologists, and psychologists."--

Anmerkung: Description based upon print version of record. , The developmental origins of health and disease (DOHaD) concept : past, present, and future / , Historical perspective of developmental origins of health and disease in humans / , DOHaD and the periconceptional period, a critical window in time / , Introduction to epigenetic mechanisms : the probable common thread for various developmental origins of health and diseases effects / , Perinatal neurohormonal programming and endocrine disruption / , Parental nutrition and developmental origins of health and disease / , Maternal prenatal stress and the developmental origins of mental health : the role of epigenetics / , Epigenetics in the developmental origin of cardiovascular disorders / , Developmental effects of endocrine-disrupting chemicals in the ovary and on female fertility / , Developmental and eipigenetic origins of male reproductive pathologies / , Developmental origins of childhood asthma and allergic conditions : is there evidence of epigenetic regulation? / , Immune disorders, epigenetics, and the developmental origins of health and disease / , Neurobehavioral disorders and developmental origins of health and disease / , Metabolic disorders and developmental origins of health and disease / , The developmental origins of renal dysfunction / , Cancer and developmental origins of health and disease : epigenetic reprogramming as a mediator / , Epigenetic regulation of gastrointestinal epithelial barrier and developmental origins of health and disease / , How the father might epigenetically program the risk for developmental origins of health and disease effects in his offspring / , Linkage between in utero environmental changes and preterm birth / , Sexual dimorphism and DOHaD through the lens of epigenetics : genetic, ancestral, developmental, and environmental origins from previous to the next generation(s) / , Transgenerational epigenetic inheritance : past exposures, future diseases / , The placenta and developmental origins of health and disease / , The moral and legal relevance of DOHaD effects for pregnant mothers / , Introduction to Moms in Motion (MIM) / , Reversing harmful developmental origins of health and disease effects / , Informational resources for developmental origins of health and disease research / , English

Weitere Ausg.: ISBN 9780128013830

Weitere Ausg.: ISBN 0128013834

Sprache: Englisch