UID:
almafu_9960074143102883
Umfang:
1 online resource (285 p.)
Ausgabe:
1st ed.
ISBN:
9780128015681
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0128015683
Inhalt:
Systems Biology in Environmental Health: From the Genome to the Epigenome brings a systems biological perspective to recent findings that link environmental exposures to human disease. In addition to introductory chapters on molecular and cellular biology, toxicology, and computational biology, the book provides an assessment of systems-based tools that evaluate environmental health risks. This includes an overview of molecular pathways that are essential for cellular survival after exposure to environmental toxicants, recent findings on gene-environment interactions influencing enviro
Anmerkung:
Description based upon print version of record.
,
Front Cover; Systems Biology in TOXICOLOGY AND ENVIRONMENTAL HEALTH; Copyright; CONTENTS; CONTRIBUTORS; PREFACE; Chapter 1 - Systems Biology in Toxicology and Environmental Health; SYSTEMS BIOLOGY DEFINED; TECHNOLOGIES UTILIZED IN SYSTEMS BIOLOGY; APPLICATIONS OF SYSTEMS BIOLOGY IN ENVIRONMENTAL HEALTH; APPLICATIONS OF SYSTEMS BIOLOGY IN TOXICOLOGY; APPLICATIONS OF SYSTEMS BIOLOGY IN THE CLINIC; SUMMARY; REFERENCES; Chapter 2 - The Cell: The Fundamental Unit in Systems Biology; INTRODUCTION; THE CELL: STRUCTURE AND ORGANELLES; CELLULAR SIGNALING: PLASMA MEMBRANE AND SIGNAL TRANSDUCTION
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CELLULAR HOMEOSTASIS (I): ENERGY METABOLISMDECODING THE GENOME (I): TRANSCRIPTION; DECODING THE GENOME (II): TRANSLATION; CELLULAR HOMEOSTASIS (II): CELL DIFFERENTIATION, DEATH; REFERENCES; Chapter 3 - Systems Biology and the Epigenome; INTRODUCTION; DNA METHYLATION; MOLECULAR BASIS OF DNA METHYLATION; POSTTRANSLATIONAL HISTONE MODIFICATIONS; CHROMATIN; REFERENCES; Chapter 4 - Omics Technologies Used in Systems Biology; INTRODUCTION; GENOMICS; GENERATION OF MICROARRAY DATA; GENOMIC DATA GENERATION USING WHOLE TRANSCRIPTOME SHOTGUN SEQUENCING (RNA-SEQ); PROTEOMICS; METABOLOMICS; SUMMARY
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REFERENCESChapter 5 - Computational Methods Used in Systems Biology; INTRODUCTION; STUDY DESIGN FOR SYSTEMS BIOLOGY; GENETICS; EPIGENOMICS; TRANSCRIPTOMICS; PROTEOMICS; METABOLOMICS; INTEGRATION INTO A SYSTEMS FRAMEWORK; SUMMARY; REFERENCES; Chapter 6 - Priority Environmental Contaminants: Understanding Their Sources of Exposure, Biological Mechanisms, and Impacts on Health; INTRODUCTION; TOP 10 COMPOUNDS FROM THE ATSDR 2013 PRIORITY LIST OF HAZARDOUS SUBSTANCES; CARCINOGENIC, ORGANIC HAZARDOUS AIR POLLUTANTS; ENVIRONMENTAL CONTAMINANTS OF EMERGING CONCERN; CONCLUSIONS; REFERENCES
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Chapter 7 - Environmental Contaminants and the Immune System: A Systems PerspectiveINTRODUCTION: WHAT IS THE IMMUNE SYSTEM?; INNATE VERSUS ADAPTIVE OR ACQUIRED IMMUNITY; LEUKOCYTES: CELLS OF THE IMMUNE SYSTEM; CYTOKINES, CHEMOKINES, AND CHEMOTAXIS; HOW IS THE IMMUNE SYSTEM LINKED TO INFLAMMATION?; SIGNALING PATHWAYS THAT REGULATE THE IMMUNE SYSTEM; IFNΓ REGULATION OF IMMUNE FUNCTION; TGFΒ AND IMMUNE FUNCTION; NFΚB SIGNALING AND THE IMMUNE SYSTEM; TNF REGULATION OF IMMUNE FUNCTION; THE ROLE OF MAPK PROTEINS, JNK AND P38 IN THE IMMUNE RESPONSE; THE IMMUNE SYSTEM AND DISEASE STATES
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IMMUNODEFICIENCY DISEASESAUTOIMMUNE DISEASES; IMMUNE FUNCTION AND TYPE 1 DIABETES; ENVIRONMENTAL EXPOSURES AND THEIR IMPACT ON IMMUNE-RELATED SIGNALING PATHWAYS; ARSENIC AND THE IMMUNE SYSTEM; CADMIUM EFFECTS ON THE IMMUNE SYSTEM; AIR POLLUTION AND IMMUNE FUNCTION; MERCURY; CONCLUSIONS; REFERENCES; Chapter 8 - The Role of Apoptosis-Associated Pathways as Responders to Contaminants and in Disease Progression; INTRODUCTION TO APOPTOSIS; CANONICAL PATHWAYS THAT REGULATE APOPTOSIS INITIATION; APOPTOSIS SIGNALING PATHWAYS AND DISEASE; APOPTOSIS PATHWAYS THAT ARE ALTERED BY ENVIRONMENTAL COMPOUNDS
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CONCLUSIONS
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English
Weitere Ausg.:
ISBN 9780128015643
Weitere Ausg.:
ISBN 0128015640
Sprache:
Englisch
Schlagwort(e):
Electronic books.
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