UID:
almahu_9947420907702882
Format:
1 online resource (xx, 656 pages) :
,
illustrations (some color)
ISBN:
0-12-802164-0
,
0-12-802173-X
Series Statement:
Gale eBooks
Content:
Provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer's disease, along with the major hurdles that still must be overcome and potential solutions to these problems.
Note:
1. The complex pathways to mechanism-based therapeutics in Alzheimer's disease -- 2. The genetic basis of Alzheimer's disease -- 3. [beta]-secretase inhibition -- 4. [gamma]-secretase inhibitors : from chemical probes to drug development -- 5. Therapeutic targeting of A[beta]42 -- 6. Modulators of amyloid [beta]-Protein (A[beta]) self-assembly -- 7. Anti-amyloid-[beta] immunotherapy for Alzheimer's disease -- 8. Targeting A[beta] receptors to modify Alzheimer's disease progression -- 9. Blood-brain barrier transport of Alzheimer's amyloid [beta]-peptide -- 10. Alzheimer's disease therapeutics targeting apolipoprotein E -- 11. Microtubule stabilization -- 12. Tau phosphorylation as a therapeutic target in Alzheimer's disease -- 13. Stimulation of tau degradation -- 14. Passive immunotherapy for tau pathology -- 15. Inhibition of tau aggregation as a basis for treatment and prevention of Alzheimer's disease -- 16. Neuroprotective strategies for Alzheimer's disease prevention and therapy -- 17. Symptomatic cognitive enhancing agents -- 18. Tackling Alzheimer's disease by targeting oxidative stress and mitochondria -- 19. Clinical issues in Alzheimer drug development -- 20. Molecular imaging in Alzheimer clinical trials -- 21. Fluid biomarkers and diagnostics -- 22. Nonpharmacologic activity interventions to prevent Alzheimer's disease -- 23. Prospects and challenges for Alzheimer therapeutics.
Language:
English
URL:
Volltext
(URL des Erstveröffentlichers)
Bookmarklink
