Kooperativer Bibliotheksverbund

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Umfang: 1 online resource (438 pages) : , illustrations

ISBN: 9780128120637 , 0128120630 , 9780128120156 , 0128120150

Anmerkung: Front Cover -- Perinatal Stem Cells -- Perinatal Stem Cells: Research and Therapy -- Copyright -- Contents -- List of Contributors -- Preface -- I - Amniotic Fluid-Derived Stem Cells -- 1 - In Utero Therapy for Congenital Disorders Using Amniotic Fluid Stem Cells -- INTRODUCTION -- CONGENITAL DISEASES -- IN UTERO THERAPY -- Sources of Fetal Stem Cells for In Utero Transplantation of Gene-Corrected Autologous Cells -- AMNIOTIC FLUID STEM CELLS -- Access to Human Amniotic Fluid Stem Cells -- Expansion of Amniotic Fluid Stem Cells -- Gene Manipulation of Amniotic Fluid Stem Cells -- Reprogramming of Amniotic Fluid Stem Cells -- IN UTERO TRANSPLANTATION USING AMNIOTIC FLUID STEM CELLS -- In Utero Transplantation of Amniotic Fluid-Derived Mesenchymal Stem Cells -- In Utero Transplantation of Amniotic Fluid-Derived Hematopoietic Stem Cells -- TREATMENT OF STRUCTURAL CONGENITAL DISEASE IN THE FETUS -- Spina Bifida and Neurological Disorders -- Congenital Heart Defects -- Congenital Diaphragmatic Hernia -- Chest Wall Defects -- Tracheal Atresia -- Necrotizing Enterocolitis -- LIMITATIONS, RISKS, AND FUTURE DIRECTIONS -- ETHICS OF USING AMNIOTIC FLUID STEM CELL FOR IN UTERO THERAPY -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- FURTHER READING -- 2 - The Amniotic Fluid Stem Cell Secretome: At the Heart of Repair and Regeneration -- INTRODUCTION: THE PARACRINE PARADIGM -- FROM DEFECTIVE CARDIAC REPAIR TO FULL CARDIAC REGENERATION -- LOOKING FOR THE IDEAL STEM SOURCE: A ROLE FOR THE AMNIOTIC FLUID STEM CELL SECRETOME? -- The Cardioprotective Potential of Amniotic Fluid-Derived Stem Cells -- The Anti-inflammatory and Modulatory Potential of Amniotic Fluid-Derived Stem Cells -- The Angiogenic Potential of Amniotic Fluid-Derived Stem Cells -- PARACRINE PROFILING OF AMNIOTIC FLUID-DERIVED STEM CELLS. , RESURGING THE ENDOGENOUS MECHANISMS OF REGENERATION FROM WITHIN THE HEART -- LIMITS AND CHALLENGES TO OVERCOME -- CONCLUSIONS -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 3 - Transplantation of Amniotic Fluid-Derived Neural Stem Cells -- CHARACTERISTICS OF AMNIOTIC FLUID-DERIVED NEURAL STEM CELLS -- Cell Biology -- Embryonic Origin -- Multilineage Differentiation -- Epigenetic Regulation of Differentiation -- DNA Methylation -- Histone Modification -- MicroRNA -- CULTURING AMNIOTIC FLUID-DERIVED NEURAL STEM CELLS -- Harvesting of Amniotic Fluid for Research -- Clinical Considerations -- Induction of Amniotic Fluid into Amniotic Fluid-Derived Neural Stem Cells -- Culture Medium -- Excluding Amniotic Fluid-Derived Mesenchymal Stem Cells -- Verification -- Exosomes -- CURRENT USE OF AMNIOTIC FLUID-DERIVED NEURAL STEM CELLS IN RESEARCH -- Necrotizing Enterocolitis -- Hirschsprung's Disease -- Stroke -- Traumatic Brain Injury -- Neurodegenerative Disorders -- Spinal Cord Injury -- Limitations and Challenges of Stem Cell Use -- CONCLUSIONS -- LIST OF ACRONYMS AND ABBREVIATIONS -- REFERENCES -- 4 - Stroke Therapy: The Potential of Amniotic Fluid-Derived Stem Cells -- INTRODUCTION -- CELL TRANSPLANTATION STUDIES IN STROKE -- ISOLATION AND CHARACTERIZATION OF AMNIOTIC FLUID-DERIVED STEM CELLS -- AMNIOTIC FLUID-DERIVED STEM CELL IN CELL THERAPY: ADVANTAGES AND CHALLENGES -- AMNIOTIC FLUID-DERIVED STEM CELLS TRANSPLANTATION IN STROKE: PRECLINICAL STUDIES -- FUNCTIONAL BENEFITS OF AMNIOTIC FLUID-DERIVED STEM CELLS: UNDERLYING MECHANISMS -- AMNIOTIC FLUID-DERIVED STEM CELLS IN STROKE: STEPS FROM EXPERIMENTAL MODELS TO THE CLINIC -- CONCLUSION -- LIST OF ACRONYMS AND ABBREVIATIONS -- GLOSSARY -- REFERENCES -- FURTHER READING -- 5 - Vascular Formation by Perinatal Stem Cells -- INTRODUCTION -- VASCULAR CELL DIFFERENTIATION. , Endothelial Differentiation of Perinatal Stem Cells -- Perinatal Stem Cells as a Mural Cell Source -- Summary of Vascular Cell Differentiation -- VASCULARIZATION TECHNIQUES -- Cellular Injection -- Cellular Aggregate Injection -- Secretome Injection -- In Situ Scaffold Implantation -- Prevascularization Strategies -- Summary of Vascularization Techniques -- CONCLUSION AND FUTURE TRENDS -- LIST OF ACRONYMS AND ABBREVIATIONS -- GLOSSARY -- ACKNOWLEDGMENT -- REFERENCES -- 6 - Amniotic Fluid Stem Cells for Kidney Regeneration -- INTRODUCTION -- AMNIOTIC FLUID -- AMNIOTIC FLUID COMPOSITION -- AMNIOTIC FLUID CELLS -- Amniotic Fluid Stem Cells -- Amniotic Fluid Mesenchymal Stem Cells -- Differentiation of Amniotic Fluid Stem Cells and Amniotic Fluid Mesenchymal Stem Cells Into Renal Lineages -- Amniotic Fluid Progenitors -- AMNIOTIC FLUID CELLS AND IMMUNOMODULATORY ACTIVITY -- AMNIOTIC FLUID PLURIPOTENT CELLS AND KIDNEY THERAPY -- Amniotic Fluid Stem Cells for the Treatment of Acute Kidney Injury -- Amniotic Fluid Stem Cells for the Treatment of Chronic Kidney Disease -- AMNIOTIC FLUID CELL APPLICATIONS IN KIDNEY BIOENGINEERING -- CONCLUSIONS -- LIST OF ACRONYMS AND ABBREVIATIONS -- REFERENCES -- FURTHER READING -- II - Placental and Placental Membrane-Derived Stem Cells -- 7 - Mending Broken Hearts: Placenta-Derived Stem Cells for Cardiomyoplasty -- INTRODUCTION -- PLACENTAL CELLULAR POPULATIONS AND EXTRACTION PROCESS -- PHENOTYPIC AND DIFFERENTIATION PROPERTIES -- IMMUNE-REGULATORY CHARACTERISTICS -- CARDIOMYOGENIC ASSAYS USING PLACENTA-DERIVED MSCS -- In Vitro Reports -- Amniotic Fluid Stem Cells -- Amniotic Mesenchymal Stromal Cells -- Chorionic Plate Mesenchymal Stem Cells -- Complete Placenta Stem Cells -- Amniotic Epithelial Stem Cells -- Decidua Basalis Stem Cells -- In Vivo Reports (Table 7.1) -- Amniotic Fluid Stem Cells. , Amniotic Mesenchymal Stromal Cells -- Chorionic Plate and Chorionic Villi Stem Cells -- Complete Placenta Stem Cells -- Amniotic Epithelial Stem Cells -- CONCLUSION -- LIST OF ABBREVIATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 8 - Heterogeneous Functions of Perinatal Mesenchymal Stromal Cells Require a Preselection Before Their Banking for ... -- INTRODUCTION -- ADULT AND PERINATAL MESENCHYMAL STROMAL CELLS: DEFINITION -- MESENCHYMAL STROMAL CELLS ARE BEING TESTED IN AN EXPANDING RANGE OF CLINICAL SETTINGS -- MESENCHYMAL STROMAL CELLS-BASED CLINICAL TRIALS YIELD SOMETIMES INCONSISTENT OR DISAPPOINTING RESULTS -- MESENCHYMAL STROMAL CELLS IS A COMPLEX CELLULAR PRODUCT CHARACTERIZED BY A FUNCTIONAL VARIABILITY -- NEED FOR PREDICTIVE TESTS TO INCREASE THERAPY EFFICIENCY -- POTENCY ASSAYS: PRESENT AND FUTURE -- IN OUR HANDS -- CONCLUSION -- REFERENCES -- 9 - Fetal Endothelial Progenitors and Mesenchymal Stem Cells From the Human Term Placenta -- INTRODUCTION -- HUMAN TERM PLACENTA -- FETAL MICROCHIMERISM TO IDENTIFY STEM CELL POPULATIONS -- MESENCHYMAL STEM CELLS -- ENDOTHELIAL PROGENITOR CELLS -- FUNCTIONALLY DEFINING ENDOTHELIAL COLONY FORMING CELLS -- Self-renewal Capacity of Endothelial Colony Forming Cells -- Potency of Endothelial Colony Forming Cells -- Molecular Definition of Placenta Endothelial Colony Forming Cells -- TRANSLATIONAL USE OF FETAL MESENCHYMAL STEM CELLS AND ENDOTHELIAL COLONY FORMING CELLS -- LIST OF ABBREVIATIONS -- DISCLOSURES -- REFERENCES -- 10 - Cotransplantation of Autologous Perinatal Hematopoietic and Mesenchymal Stem Cells for Pediatric Patients With ... -- INTRODUCTION -- PATIENTS AND METHODS -- Patients -- Treatment Regime -- Stem Cell Preparation and Transfusion -- Evaluation of Implantation and Observations -- RESULTS -- Therapeutic Efficacy -- DISCUSSION -- ACKNOWLEDGMENTS -- REFERENCES. , 11 - Epithelial and Mesenchymal Stromal Cells From the Amniotic Membrane: Both Potent Immunomodulators -- INTRODUCTION -- EFFECTS OF AMNIOTIC CELLS ON T CELLS -- In Vitro -- In Vivo -- EFFECTS OF AMNIOTIC CELLS ON MONOCYTES AND MACROPHAGES -- In Vitro -- In Vivo -- EFFECTS OF AMNIOTIC CELLS ON DENDRITIC CELLS -- In Vitro -- EFFECTS OF AMNIOTIC CELLS ON B CELLS -- In Vitro -- In Vivo -- EFFECTS OF AMNIOTIC CELLS ON NATURAL KILLER CELLS -- In Vitro -- EFFECTS OF AMNIOTIC CELLS ON NEUTROPHILS -- In Vitro -- In Vivo -- CONCLUSIONS -- LIST OF ACRONYMS AND ABBREVIATIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 12 - Bioactive Placental Tissue Matrices Modulate Stem Cell Activity to Promote Healing -- ROLE OF PLACENTAL CELLS AND TISSUES IN FETAL DEVELOPMENT -- PLACENTAL STEM CELL NICHE -- EARLY CLINICAL USE OF PLACENTAL TISSUES -- ADVANCED PRESERVATION OF PLACENTAL TISSUES -- REGULATORY LANDSCAPE FOR PLACENTAL TISSUE ALLOGRAFTS -- AMNION MEMBRANE ALLOGRAFTS -- DEHYDRATED HUMAN AMNION/CHORION MEMBRANE ALLOGRAFTS -- MOLECULAR SIGNALS IN AMNIOTIC MEMBRANE ALLOGRAFTS -- Cytokines and Growth Factors -- Extracellular Matrix -- CELLULAR CHARACTERIZATION IN RESPONSE TO AMNIOTIC MEMBRANE ALLOGRAFTS -- Cell Proliferation -- Chemotactic Migration -- Cytokine Production -- dHACM Activity in Impaired Stem Cell Populations -- PRECLINICAL ANIMAL STUDIES USING AMNIOTIC MEMBRANE ALLOGRAFTS -- Stem Cell Recruitment -- Angiogenesis -- Osteoarthritis -- Myocardial Infarction -- CLINICAL EFFICACY -- dHACM in Wound Care -- Single Layer Amnion Tissues in Wound Care -- dHACM in Additional Clinical Applications -- ADDITIONAL PLACENTAL TISSUE ALLOGRAFTS -- Umbilical Cord -- Amniotic Fluid -- Placental Collagen Matrix -- CONCLUSIONS -- REFERENCES -- 13 - Perinatal Cells and Biomaterials for Wound Healing -- INTRODUCTION -- PERINATAL TISSUES AND CELLS -- Amniotic Membrane. , Placental Mesenchymal Stromal Cells.

Sprache: Englisch

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Umfang: xx, 416 Seiten : , Illustrationen, Diagramme.

ISBN: 978-0-12-812015-6 , 0128120150

Inhalt: Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton's jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry

Anmerkung: Section I. Amniotic fluid-derived stem cells -- Section II. Placental and placental membrane-derived stem cells -- Section III. Umbilical cord-derived cells -- Section IV. Clinical and industry perspective

Weitere Ausg.: Erscheint auch als Online-Ausgabe ISBN 978-0-12-812063-7

Sprache: Englisch