Kooperativer Bibliotheksverbund

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Umfang: 1 online resource (475 pages)

ISBN: 9780128221945 , 0128221941 , 9780128224052 , 0128224053

Anmerkung: Includes index. , Front Cover -- Evidence-Based Nutrition and Clinical Evidence of Bioactive Foods in Human Health and Disease -- Copyright Page -- Contents -- Preface -- 1 Bioactive lipids and their metabolism, function, and sources -- Introduction -- Fatty acids -- Saturated FAs -- Monounsaturated FAs -- n−3 Polyunsaturated FAs -- EPA and DHA and their metabolites in health and disease -- n−6 Polyunsaturated FAs -- ARA, 20:4n−6 and its metabolites -- n−6 Eicosanoids -- Conjugated linoleic acid -- Ceramides and diacylglycerols -- Steroids -- Endocannabinoids -- Fat-soluble vitamins (vitamins A, D, E, and K) -- Conclusion -- References -- 2 Bioactive lipids and their impacts on epigenetics -- Introduction -- Fatty acids and epigenetic modifications -- Saturated fatty acids and epigenetic modification -- Short-chain fatty acids and their impacts on epigenetics -- n−3 Polyunsaturated fatty acids and their impacts on epigenetics -- n−3 Fatty acids and their effects on the feto-placental epigenetics -- n−6 Polyunsaturated fatty acids and the epigenetics -- Monounsaturated fatty acids and their impacts on the epigenome -- Trans-fatty acids and their impacts on epigenetics -- Conclusion -- References -- 3 Bioactive lipids in cancers -- Introduction -- n−3 and n−6 fatty acids modulate cancers -- Lipids and their roles in cellular processes in cancer -- Lipids are signaling mediators in cancer biology -- Uptake of fatty acids and their intracellular transport in cancer biology -- Lipids in angiogenesis -- Lipids in cancer therapy -- Short-chain fatty acids and cancer -- Conclusion -- References -- 4 Bioactive lipids in immune cells function and immune disorders -- Abbreviations -- Introduction -- Fatty acids and their metabolites on the immune cell activity -- Prostaglandins and leukotrienes and their effects on immune function: modulation by dietary lipids. , Lysophospholipids and sphingolipids -- Endocannabinoids -- Synthesis of proresolving mediators and their functions in the immune system -- Human and animal studies with dietary fatty acids -- The Mediterranean diet and the immune function -- Conclusion -- Reference -- 5 Bioactive lipids in metabolic syndromes and hemostatic factors and fibrinolysis -- Abbreviations -- Introduction -- Long-chain fatty acids and metabolic syndromes -- Medium-chain fatty acids and metabolic syndromes -- Diacylglycerols and phospholipids and their effects on metabolic syndromes -- Effects of plant sterols and their derivatives on metabolic syndromes -- Effects of lipids on endothelium function -- Effects of lipids on the hemostatic and fibrinolytic factors -- Conclusion -- References -- 6 Bioactive lipids and brain function: from their mechanistic roles to clinical trials -- Abbreviations -- Introduction -- Structural and functional roles of DHA in the human brain -- Docosahexaenoic acid, 22:6n−3 and its metabolites -- The function of DHA and its metabolites in the brain -- DHA and its roles in neurocognitive function in the developmental stage -- DHA deficiency and human brain function -- DHA and dementia -- DHA and Parkinson's disease -- DHA and behavioral consequences -- Clinical trials of DHA supplementation and brain function -- Arachidonic acid and brain function -- Conclusion -- References -- 7 Bioactive lipids on platelet function and platelet-vessel-wall interactions -- Introduction -- Human blood platelets and their roles in the cardiovascular system -- Effects of dietary fatty acids and their metabolites on human blood platelets -- Platelets and vessel-wall interactions: effects of lipids -- Clinical trials with n−3 fatty acids -- Dietary recommendation and sources of n−3 fatty acids -- Conclusion -- References. , 8 Polysaccharide on diabetes, obesity, and other cardiovascular disease risk factors -- Abbreviations -- Introduction -- Gut microbiota and their roles in the metabolism of polysaccharides -- Effects of polysaccharides on insulin resistance and diabetes -- Effects of polysaccharides on obesity and other cardiovascular disease factors -- Conclusion -- References -- 9 Polysaccharides on the gut microbiome and epigenome -- Introduction -- The gut microbiota and their effects on the epigenome -- The gut microbiota and the epigenetic regulation of disease -- Conclusion -- References -- 10 Polysaccharides and their bioactivity and biomedical applications -- Introduction -- Physicochemical characteristics of polysaccharides and their impacts on biology -- Microbial fermentation of polysaccharides -- Polysaccharides from different sources -- Bioactive polysaccharides of different sources -- Polysaccharides as an antimicrobial agent -- Antitumor activity of polysaccharides -- Antiobesity and hypocholesterolemic effects of polysaccharides -- Antidiabetic effects of polysaccharides -- Protective effects of polysaccharides on the gastrointestinal tract -- Roles of polysaccharides in the immune response and inflammation -- Polysaccharides and brain function -- Antioxidant activity of polysaccharides -- Tissue repairing -- Wound healing and polysaccharides -- Polysaccharides and drug delivery -- Use of polysaccharide in vaccines -- Anticoagulant activity of polysaccharides -- Polysaccharides as nutraceuticals -- Conclusion -- References -- 11 Polysaccharides and immune function -- Introduction -- Immunomodulatory function of polysaccharides -- Effect of polysaccharides on the production of cytokines and NO by macrophages -- Effects of polysaccharides on the activation of macrophages -- Polysaccharides regulate the immune system. , A metaanalysis of polysaccharides effects on the immune system -- Conclusion -- References -- 12 Polysaccharides on metabolic syndromes and dyslipidemia -- Introduction -- Effects of polysaccharides on metabolic syndromes -- Polysaccharides: their source and biological activity -- Effects of polysaccharides and lipid metabolism -- Gut microbiota and their impacts on metabolic syndromes and hyperlipidemia -- Conclusion -- References -- 13 Polysaccharides and cancer -- Introduction -- Effects of polysaccharides on cancer cells -- Depolarization of mitochondrial membrane and reactive oxygen species: effects of polysaccharides -- Effects of polysaccharides on nitric oxide pathway -- Immunomodulation by polysaccharides -- Anticancer effects of polysaccharides and their classifications -- Selective cytotoxicity -- Polysaccharides in cancer trials -- Conclusion -- References -- 14 Polyphenols and their antioxidant and nonantioxidant effects in health and disease -- Introduction -- Biochemistry of free radicals in the body -- Oxidative stress and human diseases -- The antioxidant system in the body -- Antioxidant and nonantioxidant of activities of dietary polyphenols -- Polyphenols, their source, and bioavailability -- Effects of polyphenols as an antioxidant and their impacts on human diseases -- Effects of polyphenols on obesity -- Cardioprotective effects of polyphenols -- Effects of polyphenols on diabetes mellitus -- Effects of polyphenols on cancers -- Antiaging effects of polyphenols -- Polyphenols and neurodegenerative disorders -- Conclusion -- References -- 15 Polyphenols in neuroprotection and brain disorders -- Introduction -- Epidemiology of neurodegenerative diseases and the underlying causes -- Polyphenols and their source, bioavailability, and their neuroprotection activity -- Polyphenols and brain health. , Studies on the potency of the mixture of polyphenols -- Effects of polyphenols: in vitro studies -- Studies on neuroprotection of polyphenols in cell models -- Studies on neuroprotection of polyphenols in the animal model -- Clinical trials -- Polyphenols and blood-brain barrier -- Conclusion -- References -- 16 Polyphenols and their impacts on the host epigenome and the gut microbiome -- Introduction -- Epigenome and gut microbiota in health and diseases -- Dietary polyphenols -- Gut microbiota and polyphenols -- The interplay between polyphenols and the gut microbiota and impacts on disease -- Conclusion -- References -- 17 Polyphenols and cancer -- Introduction -- Polyphenols -- Epidemiological observation of the anticancer effects of polyphenols -- Chemopreventive effects of polyphenols -- Various polyphenols and their specific anticancer actions -- Phenolic acids -- Lignans -- Anticancer effects of mixtures of polyphenols -- Effects of polyphenols in cancer metastasis -- Conclusion -- References -- 18 Polyphenols and their effects on metabolic syndromes and other CVD risk factors -- Introduction -- Metabolic syndromes -- Effects of polyphenol intake on the features of metabolic syndrome -- Epidemiological studies on the association between the intake of polyphenols and MetS and CVD risk factors -- Association between polyphenol intake and insulin resistance -- Association between polyphenol intake and the incidence of hypertension -- Association between polyphenol intake and other CVD risk factors -- Clinical trials with polyphenols -- Long-term interventions with polyphenols in patients with MetS -- Gut microbiota, polyphenols, and metabolic syndrome -- Conclusion -- References -- 19 Gut microbiota on human health and disease -- Introduction -- Development and establishment of the human gut microbiota. , Dysbiosis of gut microbiota and human diseases.

Sprache: Englisch