UID:
almahu_9949198460302882
Format:
XX, 486 p.
,
online resource.
Edition:
1st ed. 1980.
ISBN:
9781461330721
Note:
1 Chemical Mutagens and Sister-Chromatid Exchange -- 1. Introduction -- 2. Sister-Chromatid Exchange as a Measure of Chromosome Damage -- 3. Systems and Methods t2 -- 4. Summary -- 5. References -- 2 Modification of Mutagenic Activity -- 1. Introduction. 41 2. Factors That Influence Metabolic Activation t2 -- 3The Detection of Chemical Mutagens/Carcinogens by DNA Repair and Mutagenesis in Liver Cultures -- 1. Introduction -- 2. Types of Chemical Carcinogens -- 3. Metabolic Activation Capability of Liver -- 4. Liver Cultures -- 5. Carcinogen Metabolism in Liver Cultures -- 6. Hepatocyte Primary Culture/DNA Repair Assay -- 7. Mutagenesis of Rat Liver Epithelial Lines -- 8. Hepatocyte-Mediated Mutagenesis of Rat Liver Epithelial Lines -- 9. Discussion -- 10. References -- 4 Commercial Screening of Environmental Chemicals -- 1. Introduction -- 2. Transfer of Technology -- 3. Goals of Genetic Toxicology in Chemical Safety Evaluation -- 5. Legal Operation Requirements -- 6. Summary -- 7. References -- 5 Determining the DNA-Modifying Activity of Chemicals Using DNA-Polymerase-Deficient Escherichia coli -- 1. Introduction -- 2. Materials and Methods -- 3. Standard Assay -- 4. Modified Assay -- 5. Microsomal Activation -- 6. Results and Discussion -- 7. Comparison of the Pol A and Salmonella Assays -- 8. References -- 6 Screening of Environmental Chemical Mutagens by the Rec-Assay System with Bacillus subtilis -- 1. Introduction -- 2. Principles and Related Background of the Rec-Assay -- 3. Experimental Procedures -- 5. Rec-Assays on Chemical Carcinogens -- 7 Transformation of Syrian Hamster Embryo Cells by Diverse Chemicals and Correlation with Their Reported Carcinogenic and Mutagenic Activities -- 1. Introduction -- 2. Mammalian Cell Transformation Systems as Prescreens for Identifying Carcinogens in the Environment -- 3. Hamster Embryo Cell in Vitro Carcinogenesis Bioassay -- 4. Correlation of Transformation Response with Reported Carcinogenicity and Mutagenicity -- 5. Metabolic Activation -- 6. A Battery vs. a Tier of Short-Term Tests for Identifying Potentially Carcinogenic Chemicals -- 7. Conclusions -- 8. References -- 8 Chemical Mutagenesis in the Silkworm -- 1. Introduction -- 2. Methods for Mutation Detection in the Silkworm -- 3. Procedures for Administration of Chemicals -- 5. Mosaics and Delayed Mutagenesis -- 6. Exploitation of a Sensitive Test System with Oocytes -- 7. Screening of Environmental Mutagenic Compounds -- 8. Modification of Mutagenicity by Metabolic Activation -- 9. Conclusion -- 10. References -- 9 The Use of Short-Term Tests in the Isolation and Identification of Chemical Mutagens in Complex Mixtures -- 1. Introduction -- 2. Extraction Methodology -- 3. Mutagenesis Assay Methodology -- 10 Mathematical Analysis of Mutation-Induction Kinetics -- 1. Introduction -- 2. Definitions -- 3. Stochastic Description of Mutagenesis and Killing -- 4. Formal Dose-Response Patterns -- 5. The Linear Response Pattern (Lk,Lm) -- 6. Nonlinear Response Patterns -- 7. Illustrative Calculations of Yield Curves -- 8. Relative Mutagenic Efficiency (RME) -- 9. Stochastic Dependence of Mutation and Killing -- 10. Repair-Mediated Mutagenesis -- 11. Concluding Remarks -- 12. Summary -- 13. Appendix t2 -- 11 Comparison of the Mutagenic Effect of Ultraviolet Radiation and Chemicals in Normal and DNA-RepairDeficient Human Cells in Culture -- 1. Introduction -- 2. Procedures -- 3. Evidence that Excision Repair Can Eliminate Potentially Cytotoxic and Mutagenic Lesions from DNA -- 12 Gene-Locus Mutation Assays in Diploid Human Lymphoblast Lines -- 1. Introduction -- 2. Exposure -- 4. Selection Systems -- 5. Experimental Observations -- 6. Discussion -- 7. References -- 13 The Need for Both in Vitro and in Vivo Systems in Mutagenicity Screening -- 1. Introduction -- 3. Correlations between Carcinogenicity and Mutagenicity in Salmonella -- 4. Construction of a Table of 465 Compounds with Known or Suspected Carcinogenic Activity (Table 4) -- 5. Discussion of False Negatives from Table 4 -- 6. Validation of Salmonella Testing as a Predictor of Carcinogenicity -- 7. Concluding Comments on Mutagenicity Testing -- 8. References.
In:
Springer Nature eBook
Additional Edition:
Printed edition: ISBN 9781461330745
Additional Edition:
Printed edition: ISBN 9780306403644
Additional Edition:
Printed edition: ISBN 9781461330738
Language:
English
DOI:
10.1007/978-1-4613-3072-1
URL:
https://doi.org/10.1007/978-1-4613-3072-1
Bookmarklink
