UID:
almahu_9949984016002882
Umfang:
1 online resource (460 pages)
Ausgabe:
1st ed.
ISBN:
9780443132100
Inhalt:
This book, 'Cancer Epigenetics and Nanomedicine: Targeting the Right Player,' edited by Prashant Kesharwani and Chitra Thakur, explores the complex interplay between cancer epigenetics and nanotechnology in developing targeted cancer therapies. It delves into the mechanisms of cancer, including tumor metabolism, the role of one-carbon amino acids, and environmental causes of cancer. The book underscores the significance of epigenetic modifications in cancer progression and treatment, discussing DNA methylation, histone modifications, and chromatin remodeling as pivotal factors in cancer biology. Additionally, it highlights the potential of nanomedicine in delivering targeted treatments by modulating epigenetic pathways. Aimed at researchers, practitioners, and students in oncology and medical sciences, this book provides insights into the latest advancements in cancer treatment, emphasizing the integration of epigenetic and nanotechnology approaches to improve therapeutic outcomes.
Anmerkung:
Intro -- Cancer Epigenetics and Nanomedicine: Targeting the Right Player via Nanotechnology -- Copyright -- Contents -- Contributors -- About the editors -- Preface -- Acknowledgments -- Section 1: Overview of cancer, internal and external factors associated with cancer -- Chapter 1: Overview of cancer: Mechanisms of carcinogenesis -- Introduction -- Cancer: A historical perspective -- Origin of cancer: Theories and drivers of carcinogenesis -- Theories of cancer origin -- Mechanisms of carcinogenesis -- Endogenous and exogenous factors affecting DNA -- DNA repair -- Oncogenes and tumor suppressor genes -- Sustained proliferation -- Cell death and resistance -- Angiogenic switch -- Tissue invasion and metastasis -- The tumor microenvironment -- Hallmarks of cancer -- Epigenetics and cancer -- DNA methylation in cancer -- Histone modifications -- Nucleosome positioning -- Noncoding RNAs -- Conclusion -- References -- Chapter 2: Tumor metabolism and micronutrients: New insights to target malignant tumors -- Introduction -- Role of micronutrients in targeting malignant tumors -- Impact of iron levels on cancer proliferation -- Targeting intracellular iron levels to induce cellular death -- Impact of calcium levels on cancer proliferation -- Targeting calcium levels to induce cellular death -- Impact of magnesium levels on cancer proliferation -- Targeting Warburg effect to induce tumor cell death -- Role of glycolytic enzymes in inducing cancer cell death -- Other metabolic pathways used by tumor cells -- Interplay between glutaminolysis and Warburg effect -- Discussion and conclusion -- Author contributions -- Conflict of interest -- Acknowledgments -- References -- Chapter 3: The role of one-carbon amino acids in tumor-immune metabolism: From oncogenesis to therapy -- Introduction -- One-carbon metabolism -- Methionine -- Serine.
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One-carbon metabolism and T-cell function -- Dependency of methionine metabolism in T-cells -- Dependency of serine metabolism in T-cells -- Restriction of AAs as therapy -- Therapeutic restriction of methionine -- Therapeutic restriction of serine -- Conclusion and future directions -- References -- Chapter 4: Environmental causes of cancer -- Introduction -- Smoking and tobacco use -- Radiation -- Alcohol consumption -- Diet and obesity -- Air pollution -- Water pollution -- Soil pollution -- Lead -- Cadmium -- Polycyclic aromatic hydrocarbons -- Asbestos -- Pathogenic microbes -- Environmental carcinogens -- Aflatoxins -- Benzene -- Hexavalent chromium compounds -- Perspectives -- References -- Chapter 5: Cancer stem cells-Challenges for cancer therapies -- Introduction -- The identification of the CSCs -- CSCs in tumorigenesis models -- Biology of CSCs -- Challenges posed by CSCs in cancer therapies -- Ambiguity of the CSC markers -- Crosstalk among the regulatory pathways -- CSC-mediated tumor dormancy -- Enhanced drug efflux activity of CSCs -- Increased DNA repair in CSCs -- Enhanced autophagy and mitophagy in CSCs -- Suppressed ferroptosis in CSCs -- Metastatic potential of CSCs -- Hypoxic adaptation -- CSCs generate a tumor supporting niche -- Epigenetic regulation -- Perspective -- References -- Chapter 6: Carving a therapeutic niche for metastatic cancer: Opportunities and challenges -- Introduction -- Hallmarks of cancer -- History of metastasis -- Mechanism of metastasis -- Challenges for therapy of metastasis -- Conclusion -- References -- Section 2: Epigenetics and its importance in cancer therapies -- Chapter 7: An overview of epigenetics and cancer -- Role of epigenetics in normal and cancer cells -- Epigenetics mechanism and their regulation on cancer -- DNA methylation in cancer -- Role of histone modifications in cancer.
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Chromatin remodeling in cancer -- Alterations in chromatin remodeling enzymes -- Aberrations in nucleosome positioning -- DNA methylation and histone methylation cross-talks -- Role of epigenetic dysregulation of noncoding RNAs in cancer -- Epigenetic dysregulation in cancer stem cells, a promise for therapeutic intervention -- Epigenetics in the clinics: Prognostics, diagnostics, and therapeutic intervention for cancers -- Harnessing epigenetics mechanism in prognosis and diagnosis of cancer -- Epigenetic therapy: A targeted approach to cancer treatment -- Advancements and innovation in epigenetic technologies in investigating mechanisms in cancer cells -- Epigenetic profiling -- Epigenome editing -- Single-cell epigenomics -- References -- Chapter 8: Metabolic adaptation and epigenetic modulations: Unraveling tumor plasticity under variable tumor microenvironment -- Introduction -- Metabolic adaptation to TME -- Metabolic microenvironment in solid tumors -- TME altered metabolic pathways -- Glucose metabolism -- Amino acid metabolism -- Lipid metabolism -- Metabolic reprogramming via transcription factors in the TME -- p53 -- HIFs -- NF-κB -- ROS and redox signaling in a harsh TME -- Epigenetic and metabolic crosstalk in TME -- DNA methylation -- RNA methylation -- Chromatin modifications -- Chromatin remodeling -- Histone methylation -- Histone acetylation -- Histone lactylation -- Noncoding RNA -- lncRNA -- miRNA -- Metabolic plasticity -- Epigenetic modifications in shaping the TME -- Epithelial-mesenchymal plasticity -- Cancer cell dormancy -- Intratumor heterogeneity leading to phenotypic variation -- References -- Chapter 9: Involvement of epigenetic modifications in cancer stem cells and chemoresistance -- Tumor heterogeneity and drug resistance -- Cancer stem cells: A new dimension to drug resistance.
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Reprogramming of cancer stem cells and epigenetic modifications -- DNA methylation -- Histone modifications -- Histone methylation and demethylation -- Histone acetylation and deacetylation -- Noncoding RNAs -- Micro-RNAs (miRNA) -- Long noncoding RNAs (lncRNA) -- RNA methylation -- Epigenetic involvement in drug resistance -- Therapeutic targeting of epigenetic alterations in cancers -- DNMT inhibitors -- Histone deacetylase (HDAC) inhibitors -- Histone methyltransferase inhibitors -- Combinatorial strategies for epigenetic therapeutics -- References -- Chapter 10: Cancer biomarkers: Where genetics meets epigenetics -- Epigenetics in cancer biology -- Histone modifications -- Histone acetylation -- Histone methylation -- Histone PTMs as cancer biomarkers -- DNA methylation -- Chromatin remodeling complexes -- Noncoding RNAs -- miRNAs in cancer -- miRNA-based therapeutic strategies -- Conclusion -- References -- Chapter 11: Epigenetics approach in cancer treatment with focus on lung and breast cancer -- Introduction to epigenetics in breast and lung cancer -- DNA methylation in breast and lung cancer -- Chromatin remodeling and HDAC inhibition -- Role of miRNAs as epigenetic biomarkers -- Scope of epidrugs -- Future directions -- References -- Chapter 12: Dietary components as epigenetic modifiers and their roles in cancer prevention -- Introduction -- Epigenetic mechanisms and its importance in cancer -- Crosstalk between dietary components and metabolism in epigenetic regulation -- Types of dietary components and their role in epigenetics and chemoprevention -- Dietary polyphenols -- Epigallocatechin-gallate -- Sulforaphane -- Resveratrol -- Curcumin -- Quercetin -- Genistein -- Conclusion -- References -- Section 3: Nanomedicine targeting epigenetic machinery in cancer therapy.
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Chapter 13: Harnessing plant-derived biosynthetic nanomaterials for epigenetic modulation in cancer therapy -- Introduction -- Epigenetic modulation in cancer -- Current approaches for epigenetic modulation in cancer therapy -- Biosynthetic nanomaterials from plants -- Plant-based nanomaterials used in cancer research -- Plant-derived nanoparticles -- Plant secondary metabolites -- Plant-based polymeric nanoparticles -- Epigenetic modulation by biosynthetic nanomaterials -- Plant-derived nanoparticles for targeted delivery of epigenetic modifiers -- Plant secondary metabolites as natural epigenetic modulators -- Plant-based polymeric nanoparticles for sustained release of epigenetic drugs -- Experimental evidence and preclinical studies -- Clinical potential and future directions -- Conclusion -- References -- Chapter 14: Nanotechnology-enhanced immunotherapy for cancer -- Introduction -- The fundamentals of the immune system -- T-cell ontogeny -- T-cell activation signals -- Tumor immunology -- Immune responses against tumors -- Adoptive T-cell therapy for combating cancers -- Immune checkpoints and their role in cancer immunotherapy -- CTLA-4 -- PD-1/PD-L1 pathway -- TIGIT -- LAG3 -- Other therapies -- Nanotechnological advances in immunotherapy -- References -- Chapter 15: Nanoparticles in metastatic cancer treatment -- Introduction -- Understanding metastasis in cancer -- NPs for drug delivery -- Fundamentals and rationale for using NPs in cancer treatment -- Applications of NPs for drug deliverance -- Targeted drug delivery methodologies -- Passive targeting: EPR effect (enhanced permeability and retention) -- Active targeting -- Intracellular/intramolecular targeted therapies -- Applications in metastatic cancer treatment -- Conclusion and future perspectives -- Acknowledgments -- References.
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Chapter 16: Amine-terminated dendrimers: A novel method for diagnose, control and treatment of cancer.
Weitere Ausg.:
Print version: Kesharwani, Prashant Cancer Epigenetics and Nanomedicine San Diego : Elsevier Science & Technology,c2024 ISBN 9780443132094
Sprache:
Englisch
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