UID:
almahu_9949983993402882
Umfang:
1 online resource (xvii, 539 pages) :
,
illustrations (some color).
Ausgabe:
1st ed.
ISBN:
9781283754354
,
1283754355
,
9780444595843
,
0444595848
Serie:
Handbook of Clinical Neurology
Inhalt:
Neurological Rehabilitation is the latest volume in the definitive Handbook of Clinical Neurology series. It is the first time that this increasing important subject has been included in the series and this reflects the growing interest and quality of scientific data on topics around neural recovery and the practical applications of new research. The volume will appeal to clinicians from both neurological and rehabilitation backgrounds and contains topics of interest to all members of the multidisciplinary clinical team as well as the neuroscience community. The volume is divided into five key
Anmerkung:
Description based upon print version of record.
,
Front Cover; Neurological Rehabilitation; Copyright; Handbook of Clinical Neurology 3rd Series; Foreword; Preface; Contributors; Contents; Section 1: Translational neuroscience; Chapter 1: Neural plasticity and its contribution to functional recovery; Definition; Sites of plasticity; Window of opportunity; Functional relevance; Plasticity, metaplasticity, and homeostatic plasticity; Genetic Influences; Noninvasive techniques capable of evaluating neuroplasticity in humans; Modulation of neuroplasticity; Conclusions; Acknowledgments; References; Chapter 2: Plasticity of cerebral functions
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IntroductionNatural history of recovery after stroke; Mechanisms underlying recovery after cortical injury; Plasticity in the somatotopy of cortical motor maps as a reflection of vicarious function; Premotor cortex as a potential locus for vicarious function; Structural changes in motor cortex after stroke; Summary; References; Chapter 3: Neuroplasticity in the spinal cord; Introduction; Spinal cord injury; Mechanisms of plasticity in recovery from spinal cord injury; Physiological and molecular plasticity; Denervation supersensitivity; Reduced transmitter inactivation
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Use-dependent plasticityShort-term potentiation and depression; Long-term potentiation and depression; Long-term potentiation; Long-term depression; Habituation; Anatomical plasticity; Collateral sprouting; Dendritic remodeling; Regeneration; Regeneration vs. plasticity; Overcoming inhibition; Rho/Rho kinase pathway modulators; Blocking ROCK: Cethrin and fasudil; Blocking Nogo: antibody-mediated neutralization or receptor blockade; Chondroitinase ABC; Enhancing intraneuronal mechanisms of growth; Cyclic AMP; PTEN/mTOR; Combination therapies: cell- and tissue-based therapies; Bridge formation
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Neural networksConclusions; References; Chapter 4: Neural tissue transplantation, repair, and rehabilitation; Introduction; Cell replacement and structural repair by neural transplantation; Cell source; Cell transplantation; Immunological factors; Mechanisms of functional recovery after neural transplantation; Neuroendocrine/neurochemical replacement; Maximizing circuit repair; Minimal conditions for recovery; Transplant-derived plasticity; Behavioral experience affects transplant integration and function; Environmental enrichment; Motor activity and training
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Learning (and relearning) to use the transplantLearning to use the transplant; Learning using the transplant; Rehabilitation strategies to promote transplant function; Acknowledgments; References; Chapter 5: Clinical trials in neurorehabilitation; Introduction; Complexity of human randomized clinical trials; Recruitment; Retention; Treatment fidelity; Treatment integrity; Strategies to promote treatment integrity; Treatment differentiation; Control intervention; Beyond randomized controlled trials; Study design; Interpretation of results; Outcome measurement
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Translation of evidence from clinical trials in neurorehabilitation to clinical practice
,
English
Weitere Ausg.:
ISBN 9780444529015
Weitere Ausg.:
ISBN 0444529012
Sprache:
Englisch
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