UID:
almafu_9959327587902883
Format:
1 online resource (xiv, 312 pages, [4] pages) :
,
illustrations (some color)
ISBN:
9780470754221
,
0470754222
,
9786612343223
,
6612343222
,
0470754214
,
9780470754214
Content:
"Aimed at specialists in pulmonology, this volume provides the clinician with the most up to date information on one of the core physiological processes in airway disease, and offers insights into current and future approaches to management." (Doody's Reviews, March 2009).
Note:
Airway Smooth Muscle -- Contents -- List of Contributors -- 1 Biophysical basis of airway smooth muscle contraction and hyperresponsiveness in asthma -- 1.1 Introduction -- 1.2 Airway hyperresponsiveness -- 1.3 Classical behaviour of airway smooth muscle and the balance of static forces -- 1.4 Shortening velocity and other manifestations of muscle dynamics -- 1.5 Biophysical characterization of airway smooth muscle: bronchospasm in culture? -- 1.6 Mechanical plasticity: a nonclassical feature of airway smooth muscle -- 1.7 Recent observations -- 1.8 Future directions -- References -- 2 Dynamics of cytoskeletal and contractile protein organization: an emerging paradigm for airway smooth muscle contraction -- 2.1 Introduction -- 2.2 Molecular structure and organization of contractile and cytoskeletal filaments in the airway smooth muscle cell -- 2.3 Cytoskeletal dynamics and airway smooth muscle contraction -- References -- 3 Airway smooth muscle: role in airway constrictor hyperresponsiveness -- 3.1 What is airway constrictor hyperresponsiveness (AHR)? -- 3.2 Is AHR ever good? -- 3.3 Potential mechanisms leading to airflow obstruction -- 3.4 Potential abnormalities of airway smooth muscle (ASM) -- 3.5 If ASM is dysfunctional, how did it get that way? -- 3.6 Summary -- Acknowledgements -- References -- 4 Airway smooth muscle phenotypic and functional plasticity -- 4.1 Introduction -- 4.2 Historical perspective: smooth muscle phenotype plasticity -- 4.3 Features of phenotype plasticity -- 4.4 Mechanisms for phenotypic plasticity -- 4.5 Functional plasticity of airway smooth muscle: role in asthma pathogenesis -- 4.6 Concluding remarks -- References -- 5 Airway smooth muscle proliferation: insights into mechanisms regulating airway smooth muscle mass -- 5.1 Increases in airway smooth muscle (ASM) mass and the functional consequences.
,
5.2 Growth factors, inflammatory mediators and cytokines modulate ASM proliferation -- References -- 6 Airway smooth muscle bidirectional interactions with extracellular matrix -- 6.1 Overview -- 6.2 Introduction -- 6.3 Airway extracellular matrix (ECM) in health and disease -- 6.4 Integrins -- 6.5 Airway smooth muscle (ASM) as a modulator of airway ECM -- 6.6 Airway ECM as modulator of ASM function -- 6.7 Impact of anti-asthma therapy on ASM-ECM interactions -- 6.8 Conclusions -- Acknowledgements -- References -- 7 Airway smooth muscle interaction with mast cells -- 7.1 Introduction -- 7.2 Mast cell mediators alter smooth muscle function -- 7.3 Smooth muscle cells induce mast cell chemotaxis -- 7.4 Mast cells can adhere to airway smooth muscle -- 7.5 Conclusion -- Acknowledgements -- References -- 8 Airway smooth muscle synthesis of inflammatory mediators -- 8.1 Introduction -- 8.2 Lipid mediators -- 8.3 Chemokines -- 8.4 Growth and remodelling factors -- 8.5 Conclusions -- References -- 9 Airway smooth muscle in experimental models -- 9.1 Introduction -- 9.2 Methods of assessment of airway smooth muscle (ASM) function -- 9.3 Potential mechanisms by which ASM properties may contribute to airway responsiveness -- 9.4 Experimental models -- 9.5 Conclusion -- Acknowledgement -- References -- 10 Altered properties of airway smooth muscle in asthma -- 10.1 Introduction -- 10.2 The extracellular matrix (ECM) and the airway smooth muscle (ASM) -- 10.3 ASM and integrins -- 10.4 The ASM cell and inflammation -- 10.5 The ASM cell and infection -- References -- 11 The airway smooth muscle in chronic obstructive pulmonary disease (COPD) -- 11.1 Introduction -- 11.2 Definition and assessment of COPD -- 11.3 Pathological features of COPD -- 11.4 COPD mechanisms -- 11.5 Conclusion -- References -- 12 Glucocorticoid actions on airway smooth muscle.
,
12.1 Introduction -- 12.2 Airway smooth muscle (ASM) in airways disease -- 12.3 Gene induction by glucocorticoid receptors (GR) -- 12.4 Actions of B2-agonists and glucocorticoids on growth, proliferation, and migration of ASM -- 12.5 Summary and conclusions -- Acknowledgements -- References -- 13 B2-Adrenergic receptors: effects on airway smooth muscle -- 13.1 The B2-adrenoceptor -- 13.2 B2-Receptor activation -- 13.3 B2-Receptor signalling pathways -- 13.4 Effects in airway smooth muscle (ASM) -- 13.5 B2-Receptor desensitization -- 13.6 Influence of polymorphisms of the B2-adrenoceptor in ASM -- 13.7 Non-bronchodilator effects of B2-agonists in ASM -- 13.8 Conclusion -- References -- 14 Asthma treatments: effects on the airway smooth muscle -- 14.1 Introduction -- 14.2 Role and abnormalities of airway smooth muscle (ASM) in asthma and COPD -- 14.3 Treatment of asthma -- 14.4 Conclusion -- References -- Index -- Color Plates.
,
English.
Additional Edition:
Print version: Airway smooth muscle in asthma and COPD. Hoboken, N.J. ; Chichester : Wiley, 2008 ISBN 9780470060667
Additional Edition:
ISBN 0470060662
Language:
English
Keywords:
Electronic books.
;
Electronic books.
;
Electronic books.
DOI:
10.1002/9780470754221
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470754221
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470754221
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470754221
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