UID:
almafu_9959328382802883
Umfang:
1 online resource (xxviii, 402 pages, 12 unnumbered pages of plates) :
,
illustrations (some color)
ISBN:
9780470386385
,
047038638X
,
9780470386378
,
0470386371
Inhalt:
An important reference which provides an overview of the current and recently introduced methodologies for testing the immunotoxic risks in drug candidates; Helps readers understand the significance of the methods and approaches to immunotoxicology testing; Aids drug scientists in industry and regulatory areas to consolidate approaches to immunotox testing; Offers a definitive assessment of nonclinical models to study the toxic impacts (bio)pharmaceuticals can have on the immune system; Includes chapter authors from across the pharma industry, bringing a real-world and applied perspective to i.
Anmerkung:
Current regulatory expectations for immunotoxicologyy evaluation of pharmaceuticals / Kenneth L. Hastings -- Clinical pathology as crucial insight into immunotoxicity testing / Ellen Evans -- Histomorphology of the immune system : a basic step in assessing immunotoxicity / Patrick Haley.
,
Need for specialized immunotoxicity tests / Kazuichi Nakamura -- Specific drug-induced immunotoxicity : immune-mediated hemolytic anemia / Raj Krishnaraj -- T cell-dependent antibody response tests / Joseph R. Piccotti -- Natural killer cell assay and other innate immunity tests / Lisa Plitnick -- Cellular immune response in delayed-type hypersensitivity test / Karen Price -- Evaluation of drug effects on immune cell phenotypes / Laurie Iciek.
,
Functional cellular responses and cytokine profiles / Elizabeth R. Gore -- Application of flow cytometry in drug development / Padma Narayanan [and others] -- Animal models of host resistance / Gary R. Burleson and Florence G. Burleson -- Approaches to evaluation of autoimmunity / Danuta J. Herzyk.
,
Differentiating between desired immunomodulation and potential immunotoxicity / Jeanine L. Bussiere and Barbara Mounho -- Relevant immune tests across different species and surrogate models / Jeanine L. Bussiere -- Antidrug antibody responses in nonclinical studies and their implications / Barbara Mounho -- Pharmacological immunogenicity and adverse responses to vaccines / Mary Kate Hart, Mark Bolanowski, and Robert V. House.
,
Immunotoxicological concerns for vaccines and adjuvants / Catherine Kaplanski [and others] -- Systemic hypersensitivity / Raymond Pieters -- Nonclinical models to assess respiratory hypersensitivity potential / Curtis C. Maier -- Developmental immunotoxicity in rodents / Rodney R. Dietert and Leigh Ann Burns-Naas -- Developmental immunotoxicity in nonhuman primates / Pauline L. Martin and Eberhard Buse.
,
Alternative animal models for immunomodulation and immunotoxicity / Peter J. Bugelski -- Animal models for preclinical comparative immunogenicity testing / Daniel Wierda -- T cell epitopes and minimization of immunogenicity / Harald Kropshoffer and Thomas Singer -- Bridging immunotoxicology to clinical drug development / Ian Gourley and Jacques Descotes.
Weitere Ausg.:
Print version: Immunotoxicology strategies for pharmaceutical safety assessment. Hoboken, N.J. : Wiley, ©2008 ISBN 9780470122389
Weitere Ausg.:
ISBN 0470122382
Sprache:
Englisch
Schlagwort(e):
Electronic books.
;
Electronic books.
;
Electronic books.
DOI:
10.1002/9780470386385
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470386385
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470386385
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470386385
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