UID:
almafu_9959328801902883
Format:
1 online resource (xxiv, 573 pages) :
,
illustrations
ISBN:
9780470561416
,
0470561416
,
9780470561409
,
0470561408
,
0470261005
,
9780470261002
Content:
Profiles potential treatment approaches for cardiac arrhythmias. Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century. Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments for cardiac arrh.
Note:
Myocardial K+ channels : primary determinants of action potential repolarization / Noriko Niwa and Jeanne Nerbonne -- The "funny" pacemaker current / Andrea Barbuti [and others] -- Arrhythmia mechanisms in ischemia and infarction / Ruben Coronel [and others] -- Antiarrhythmic drug classification / Cynthia A. Carnes -- Repolarization reserve and proarrhythmic risk / András Varró -- Safety challenges in the development of novel antiarrhythmic drugs / Gary Gintant and Zhi Su -- Safety pharmacology and regulatory issues in the development of antiarrhythmic medications / Armando Lagrutta and Joseph J. Salata -- Ion channel remodeling and arrhythmias / Takeshi Aiba and Gordon F. Tomaselli -- Redox modification of ryanodine receptors by heart failure and cardiac arrhythmias and failure : a potential therapeutic target / Andriy E. Belevych, Dmitry Terentyev, and Sandor Györke -- Targeting Na+/CA²+ exchange as an antiarrhythmic strategy / Gundrun Antoons, Rik Willems, and Karin R. Sipido -- Calcium/calmodulin-dependent protein kinase II (CaMKII) : modulation of ion currents and potential role for arrhythmias / Lars S. Maier -- Selective targeting of ventricular potassium channels for arrhythmia suppression : feasible or risible? / Hugh Clements-Jewery and Michael Curtis -- Cardiac sarcolemmal ATP-sensitive potassium channel antagonists : a class of drugs that may selectively target the ischemic myocardium / George E. Billman -- Mitochondrial origin of ischemia-reperfusion arrhythmias / Brian O'Rourke -- Cardiac gap junctions : a new target for antiarrhythmic drugs : gap junction modulators / Anja Hagen and Stefan Dhein -- Novel pharmacological targets for the management of atrial fibrillation / Alexander Burashnikov and Charles Antzelevitch -- IKur, ultra-rapid delayed rectifier potassium current : a therapeutic target for atrial arrhythmias / Arun Sridhar and Cynthia A. Carnes -- Non-pharmacologic manipulation of the autonomic nervous system in human for the prevention of life-threatening arrhythmias / Peter J. Schwartz -- Effects of endurance exercise training on cardiac autonomic regulation and susceptibility to sudden cardiac death : a nonpharmacological approach for the prevention of ventricular fibrillation / George E. Billman -- Dietary omega-3 fatty acids as a nonpharmacological antiarrhythmic intervention / Barry London and J. Michael Frangiskakis.
Additional Edition:
Print version: Novel therapeutic targets for anti-arrhythmic drugs. Hoboken, NJ : John Wiley & Sons, ©2010
Language:
English
Keywords:
Electronic books.
DOI:
10.1002/9780470561416
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470561416
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