UID:
almahu_9949866039002882
Format:
1 online reosurce (xx, 194 pages)
ISBN:
9781003307921
,
1003307922
,
9781040027660
,
1040027660
,
9781040027684
,
1040027687
Content:
Cancer cells exist in an ever-changing ⁰́₋ecology⁰́₊ and are subject to evolutionary pressures just like any species in nature. This edited book explores the following themes: 1) how the dynamics of mutation, epigenetics, and gene expression noise are sources of genetic diversity; 2) how scarce resources influence cancer therapy resistance; 3) how predator-prey dynamics are mirrored in immune-cancer cross-talk; 4) how cancer cells parallel niche construction theory; 5) how changing fitness landscapes enable cancer growth; and 6) how cancer cells interact within the body. The book is a resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms. Key Features Bridges disciplines exemplifying the ways disparate fields create new perspectives when integrated. Offers insights from leading scholars in cancer biology, ecology and evolutionary biology. Provides a timely recognition by oncologists that evolutionary paradigms are crucial for breakthroughs in cancer treatment. Integrates basic and applied sciences of oncology and evolutionary biology.
Note:
ForewordRandolph NesseChapter 1: A species within a speciesJason A. Somarelli and Norman A. JohnsonChapter 2: Therapy As a Driver of Evolutionary SelectionDana Ataya, Joel S. Brown and Robert A. GatenbyChapter 3: The Genetic Hitchhiker⁰́₉s Guide to Tumor EvolutionRohini Janivara and Joseph LachanceChapter 4: Multicellularity, phenotypic heterogeneity, and cancerChristopher Helenek, Jason A. Somarelli, and G©Łbor Bal©ŁzsiChapter 5: Feedback loops in gene regulatory networks and cell-cell communication networks: drivers of cancer cell plasticityYeshwanth Mahesh, Subbalakshmi Ayalur Raghu, Mohit Kumar JollyChapter 6: Polygenic Evolution of Germline Variants in CancerUjani Hazra and Joseph LachanceChapter 7: Two-phased cancer evolution: the pattern and scale of genomic and nongenomic landscapesAndrzej Kasperski and Henry H. HengChapter 8: Evolutionary and ecological perspective on the multiple states of T cell exhaustionIrina Kareva and Joel S. BrownChapter 9: Landscape Genetics for Cancer BiologyErin L. Landguth and Norman A. JohnsonChapter 10: Tumor Island Biogeography: Theory and Clinical ApplicationsAntonia ChroniChapter 11: Cancer and the Evolutionary Ecology of InvasionsJoel S. Brown, Sarah A. Amend and Kenneth J. Pienta Chapter 12: Unifying Theories in Comparative Oncology Zachary T. Compton Chapter 13: From Evolutionary Biology to Bedside and Beyond: A View of Comparative Oncology Throughout the Translational PipelineVeronica Colmenares, William C. Eward, Laurie A. Graves Chapter 14: What do we gain from viewing cancer through an eco-evo lens?Jason A. Somarelli and Norman A. Johnson
Language:
English
DOI:
10.1201/9781003307921
URL:
https://www.taylorfrancis.com/books/9781003307921
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