Format:
vi, 158 Seiten
,
Illustrationen, Diagramme
Content:
All life-sustaining processes are ultimately driven by thousands of biochemical reactions occurring in the cells: the metabolism. These reactions form an intricate network which produces all required chemical compounds, i.e., metabolites, from a set of input molecules. Cells regulate the activity through metabolic reactions in a context-specific way; only reactions that are required in a cellular context, e.g., cell type, developmental stage or environmental condition, are usually active, while the rest remain inactive. The context-specificity of metabolism can be captured by several kinds of experimental data, such as by gene and protein expression or metabolite profiles. In addition, these context-specific data can be assimilated into computational models of metabolism, which then provide context-specific metabolic predictions. This thesis is composed of three individual studies focussing on context-specific experimental data integration into computational models of metabolism. The first study presents an optimization-based method…
Note:
kumulative Dissertation
,
Dissertation Universität Potsdam, Mathematisch-Naturwissenschaftliche Fakultät 2017
Additional Edition:
Erscheint auch als Online-Ausgabe Robaina Estévez, Semidán Context-specific metabolic predictions Potsdam, 2017
Language:
English
Keywords:
Hochschulschrift
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