UID:
almafu_9959329181302883
Format:
1 online resource
ISBN:
9781118863978
,
1118863976
,
9781118864005
,
111886400X
,
9781118863992
,
1118863992
,
1118016009
,
9781118016008
Content:
Addressing a dynamic aspect of organic chemistry, this book describes synthetic strategies and applications for multicomponent reactions - including key routes for synthesizing complex molecules. - Illustrates the crucial role and the important utility of multicomponent reactions (MCRs) to organic syntheses - Compiles novel and efficient synthetic multicomponent procedures to give readers a complete picture of this class of organic reactions - Helps readers to design efficient and practical transformations using multicomponent reaction strategies - Describes reaction background, applications to synthesize complex molecules and drugs, and reaction mechanisms.
Note:
Title Page -- Copyright Page -- Contents -- List of Contributors -- Preface -- List of Abbreviations -- Chapter 1 Introduction: Multi-component Strategies -- General Introduction -- 1.1 Basic Concepts -- 1.1.1 Clarifying Terminology: One-Pot, Domino/Cascade, Tandem, and MCRs -- 1.1.2 Using Rational Design to Discover New MCRs -- 1.1.3 Discovering New MCRs with Automated Combinatorial Reaction Finding -- 1.1.4 Computational and Analytical Tools to Study MCRs -- 1.1.5 Diversity-Oriented Synthesis and Biology-Oriented Synthesis -- 1.1.6 Optimization of MCRs
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1.2 Catalysis in MCRs and Various Synthetic Approaches1.2.1 Organocatalysis in MCRs -- 1.2.2 Organometallic Catalysis in MCRs -- 1.2.3 Biocatalysis in MCRs -- 1.2.4 Combining Different Types of Catalysis -- 1.2.5 Other Methods -- 1.3 Green Chemistry -- 1.3.1 Atom Economy -- 1.3.2 Using Green Solvents -- 1.3.3 Solventless MCRs -- 1.3.4 Heterogeneous Catalysis in MCRs -- 1.4 Importance and Evolution -- References -- Chapter 2 Organocatalytic Asymmetric Multicomponent Reactions -- 2.1 Introduction -- 2.2 Three-Component Mannich Reaction
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2.3 Cycloaddition Reaction2.4 Organocatalytic Multicomponent Domino Asymmetric Reactions -- 2.4.1 Michael-Type Multicomponent Process: Cyclic Carbon Frameworks -- 2.4.2 Miscellaneous Domino Reactions -- 2.5 Development of Drug Intermediates -- 2.6 Miscellaneous Reaction -- 2.7 Conclusions -- References -- Chapter 3 Metal-Catalyzed Multicomponent Reactions -- 3.1 Introduction -- 3.2 Palladium-Catalyzed MCRs -- 3.2.1 Palladium-Catalyzed Carbonylation Reactions -- 3.2.2 Palladium-Catalyzed MCRs Involving Isocyanides
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3.2.3 Carbopalladation of Unsaturated C�C π-Components3.2.4 Amines as Building Blocks -- 3.3 Nickel-Catalyzed MCRs -- 3.3.1 Nickel-Catalyzed Cross-Trimerization of Alkynes -- 3.3.2 Nickel-Catalyzed π-Systems Couplings -- 3.3.3 Ni-Catalyzed Reductive Conjugate Addition -- 3.4 Group 11 Metal-Catalyzed MCRs -- 3.4.1 Copper-Catalyzed Azide Alkyne Cycloaddition -- 3.4.2 A3-Coupling -- 3.4.3 Miscellaneous -- 3.5 Rhodium-Catalyzed MCRs -- 3.5.1 Rhodium-Catalyzed Mcrs via Onium Ylide Intermediates -- 3.5.2 Rhodium-Catalyzed Three-Component Cross-Addition Reactions
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3.6 Group 8 Metal-Catalyzed MCRs3.6.1 Iron-Catalyzed MCRs -- 3.6.2 Ruthenium-Catalyzed MCRs -- 3.7 Conclusions -- References -- Chapter 4 Multicomponent Reactions with Organoboron Compounds -- 4.1 Introduction -- 4.2 Catalytic MCRs with Organoboron Compounds -- 4.2.1 Cobalt-Catalyzed MCRs Containing Organoboron Compounds -- 4.2.2 Palladium-Catalyzed MCRs Containing Organoboron Compounds -- 4.3 Multicomponent Assembly of Organoboron Compounds: Efficient Approach to Supramolecular Chemistry -- 4.4 Multicomponent Petasis-Borono Mannich Reaction
Additional Edition:
Print version: Multicomponent reactions. Hoboken, New Jersey : John Wiley & Sons, Inc., [2015] ISBN 9781118016008
Language:
English
Keywords:
Electronic books.
;
Electronic books.
;
Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118863992
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118863992
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118863992
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