Umfang:
Online Ressource (PDF, 17259 KB, 400 S.)
Ausgabe:
1. Aufl.
Ausgabe:
Online-Ausg. 2013 Electronic reproduction; Available via World Wide Web
ISBN:
1118275330
Inhalt:
The first text to focus on the application of click chemistry to glycoscience, this book discusses the therapeutic and pharmacological aspects of carbohydrate click chemistry and includes chapters on the concept's background, as well as its industrial applications in areas such as drug discovery. The book reflects the novel methodologies and strategies of this concept. Each chapter describes new approaches, ideas, consequences, and applications deriving from the introduction of click processes. This provides an essential reference for a wide range of researchers and graduate-level students.
Inhalt:
The first text to focus on the application of click chemistry to glycoscience, this book discusses the therapeutic and pharmacological aspects of carbohydrate click chemistry and includes chapters on the concept's background, as well as its industrial applications in areas such as drug discovery. The book reflects the novel methodologies and strategies of this concept. Each chapter describes new approaches, ideas, consequences, and applications deriving from the introduction of click processes. This provides an essential reference for a wide range of researchers and graduate-level students
Anmerkung:
Description based upon print version of record
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CLICK CHEMISTRY IN GLYCOSCIENCE; CONTENTS; FOREWORD; PREFACE; CONTRIBUTORS; LIST OF ABBREVIATIONS; PART I CLICK CHEMISTRY STRATEGIES AND DECOUPLING; 1 PARADIGM AND ADVANTAGE OF CARBOHYDRATE CLICK CHEMISTRY STRATEGY FOR FUTURE DECOUPLING; 1.1 INTRODUCTION; 1.2 COUPLING USING HUISGEN DIPOLAR CYCLOADDITION; 1.3 COUPLING USING THIOL-ENE COUPLING CLICK CHEMISTRY; 1.4 PROCESSES WHERE BOTH CuAAC AND TEC CLICK CHEMISTRIES ARE USED; 1.5 DECOUPLING; 1.5.1 Enzymatic Cleavage; 1.5.2 Photocleavage; 1.5.3 Chemical Cleavage; 1.6 CONCLUSION; REFERENCES; PART II THIO-CLICK CHEMISTRY OF CARBOHYDRATES
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2 THIO-CLICK CHEMISTRY IN GLYCOSCIENCE: OVERVIEW AND PERSPECTIVES2.1 INTRODUCTION; 2.2 THIO-BASED CLICK REACTIONS; 2.3 S-THIODISACCHARIDE SYNTHESIS; 2.4 SYNTHESIS OF GLYCOSYL THIOLS; 2.5 SYNTHESIS OF S-LINKED GLYCOSPHINGOLIPIDS; 2.6 CONCLUSION AND PERSPECTIVES; REFERENCES; 3 FREE-RADICAL THIOL-ENE AND THIOL-YNE COUPLINGS AS CLICK PROCESSES FOR GLYCOCONJUGATION; 3.1 INTRODUCTION; 3.2 S-LINKED OLIGOSACCHARIDES; 3.3 CALIX[4]ARENE-BASED GLYCOCLUSTERS; 3.4 SILSESQUIOXANE-BASED GLYCOCLUSTERS; 3.5 GLYCODENDRIMERS; 3.6 AMINO ACID, PEPTIDE, AND PROTEIN GLYCOCONJUGATES; 3.7 CONCLUSION; REFERENCES
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PART III CARBOHYDRATE CLICK CHEMISTRY FOR NOVEL SYNTHETIC TARGETS4 THE DEVELOPMENT AND APPLICATION OF CLICKABLE LIPID ANALOGS FOR ELUCIDATING AND HARNESSING LIPID FUNCTIONS; 4.1 INTRODUCTION TO THE ADVANTAGES OF APPLYING CLICK CHEMISTRY FOR STUDYING LIPIDS; 4.2 APPLICATION OF CLICK CHEMISTRY FOR THE FUNCTIONALIZATION OF MEMBRANE SURFACES; 4.3 CLICK CHEMISTRY AND THE GENERATION OF FUNCTIONALIZED LIPID ANALOGS; 4.4 DIRECT IN SITU LABELING AND IMAGING OF SYNTHETICALLY TAGGED LIPID ANALOGS; 4.5 ACTIVITY-BASED CHARACTERIZATION OF LIPID-BINDING AND LIPID-MODIFYING PROTEINS
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4.6 PROBING COVALENT PROTEIN LIPIDATION4.7 CONCLUSION; REFERENCES; 5 CLICKING SUGARS ONTO SUGARS: OLIGOSACCHARIDE ANALOGS AND GLYCOCLUSTERS ON CARBOHYDRATE SCAFFOLDS; 5.1 INTRODUCTION; 5.2 TRIAZOLE-LINKED OLIGOSACCHARIDE ANALOGS; 5.3 CLICKED CYCLODEXTRINS; 5.4 TRIAZOLE-LINKED MACROCYCLES; 5.5 MULTIVALENT GLYCOCLUSTERS ON CARBOHYDRATE SCAFFOLDS; 5.6 CONCLUSION; REFERENCES; 6 CLICK MULTIVALENT GLYCOMATERIALS: GLYCOCLUSTERS, GLYCODENDRIMERS, GLYCOPOLYMERS, HYBRID GLYCOMATERIALS, AND GLYCOSURFACES; 6.1 INTRODUCTION; 6.2 CLICK GLYCOCLUSTERS; 6.3 CLICK GLYCODENDRIMERS; 6.4 CLICK GLYCOPOLYMERS
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6.5 CLICK HYBRID GLYCOMATERIALS6.6 CLICK GLYCOSURFACES AND GLYCOARRAYS; 6.7 CLICK MULTIVALENT GLYCOMIMETICS; REFERENCES; 7 TOWARD IMAGING GLYCOTOOLS BY CLICK COUPLING; 7.1 INTRODUCTION; 7.2 NUCLEAR IMAGING AND RADIOTRACERS; 7.3 TRIAZOLE-CONTAINING RADIOTRACERS; 7.3.1 Conjugation of Labeled Carbohydrates; 7.3.2 Glycoconjugation of Radiotracers; 7.3.3 Carbohydrate Labeling; 7.4 OTHER METHODS; 7.4.1 Maillard Reaction; 7.4.2 Oxime Formation; 7.4.3 Glycosylation; 7.4.4 Disulfide Formation; 7.5 CONCLUSION AND OUTLOOK; REFERENCES; 8 BIOORTHOGONAL REACTIONS FOR LABELING GLYCOCONJUGATES
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8.1 INTRODUCTION
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Paradigm and advantage of carbohydrate click chemistry strategy for future decoupling thio-click chemistry of carbohydrates
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Thio-click chemistry overviews and perspectives
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Free-radical photoinduced thiol-Ene and thiol-Yne coupling as click processes for glycoconjugation : carbohydrate click chemistry for novel synthetic targets
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The development and application of clickable lipid analogs for elucidating lipid function
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Clicking sugars onto sugars : oligosaccharide analogue and glycoclusters on carbohydrate scaffolds
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Click multivalent glycomaterials : glycoclusters, glycodendrimers, glycopolymers, hybrid glycomatrials, and glycosurfaces
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Toward imaging glycotools by click coupling
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Bioorthogonal reactions for labeling glycoconjugates
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Sweet sucrose macrocycles via click chemistry route : carbohydrate click chemistry in biomedical sciences
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Neoglycoprotein synthesis using copper-catalyzed azide-alkyne click reaction and native chemical ligation
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Click-modified cyclodextrin for biomedical application
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Traizolyl glycoconjugates in medicinal chemistry
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Click chemistry applied to carbohydrate-based drug discovery
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Electronic reproduction; Available via World Wide Web
Weitere Ausg.:
ISBN 111852618X
Weitere Ausg.:
ISBN 1118526996
Weitere Ausg.:
ISBN 9781118526187
Weitere Ausg.:
ISBN 9781118526996
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe Click chemistry in glycoscience Hoboken, NJ : Wiley, 2013 ISBN 9781118275337
Sprache:
Englisch
Schlagwort(e):
Electronic books
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