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  • 1
    Online Resource
    Online Resource
    Replacing animal models : a practical guide to creating and using culture-based biomimetic alternatives (2012)
    Chichester, West Sussex :John Wiley & Sons,
    Details
    UID:
    almafu_9958127424702883
    Format: 1 online resource (223 p.)
    Edition: 1st ed.
    ISBN: 1-119-94098-2 , 1-280-59925-1 , 9786613629081 , 1-118-38773-2 , 1-119-94068-0 , 1-119-94067-2
    Content: Over the last decade, in vitro models have become more sophisticated and are at a stage where they can provide an effective alternative to in vivo experiments. Replacing Animal Models provides scientists and technicians with a practical, integrated guide to developing culture-based alternatives to in vivo experiments. The book is neither political nor polemical: it is technical, illustrating by example how alternatives can be developed and used and providing useful advice on developing others. After looking at the reasons for and potential benefits of alternatives to animal experiment
    Note: Includes index. , Replacing Animal Models; Contents; Contributors; Preface; Section 1 Introductory Material; 1 Potential Advantages of Using Biomimetic Alternatives; 2 Overview of Biomimetic Alternatives; Section 2 Culture Methods; 3 Pancreatic Islets; 4 Endometrial Organoid Culture; 5 Modelling Lymphatic and Blood Capillary Patterning; 6 Precision-cut Lung Slices (PCLS); 7 Human Colon Tissue in Organ Culture; 8 Fetal Organ Culture; 9 Design of a Mechanical Loading Device to Culture Intact Bovine Spinal Motion Segments under Multiaxial Motion; 10 Magnetic Assembly of Tissue Surrogates , 11 Assembly of Renal Tissues by Cellular Self-organizationSection 3 Case Studies of Use; 12 Hierarchical Screening of Pathways: Using Cell and Organ Cultures to Reduce use of Transgenic Mice; 13 Lung Organoid Culture to Study Responses to Viruses; 14 Organ-cultured Human Skin for the Study of Epithelial Cell Invasion of Stroma; 15 Organotypic Mandibular Cultures for the Study of Inflammatory Bone Pathology; 16 Three-dimensional, High-density and Tissue Engineered Culture Models of Articular Cartilage; 17 Concluding Remarks , Appendix 1 Sources of funding for development of culture-based alternativesAppendix 2 Databases and web-based discussions relevant to development of alternatives; Index; Color Plate , English
    Additional Edition: ISBN 0-470-97425-7
    Language: English
    Keywords: Aufsatzsammlung ; Electronic books. ; Electronic books. ; Electronic books.
    URL: Volltext
    URL: Inhaltsverzeichnis
    URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781119940685
    URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781119940685
    Library Location Call Number Volume/Issue/Year Availability
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    HU Berlin
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  • 2
    Online Resource
    Online Resource
    Replacing animal models : a practical guide to creating and using culture-based biomimetic alternatives (2012)
    Chichester, West Sussex, UK ; : John Wiley - Blackwell,
    Details
    UID:
    edocfu_9959328011502883
    Format: 1 online resource
    ISBN: 9781119940678 , 1119940672 , 9781119940678 , 1119940672 , 9781119940999 , 1119940990 , 9781119940685 , 1119940680 , 1118231783 , 9781118231784 , 0470974257 , 9780470974254 , 9781280599255 , 1280599251
    Content: "The book is neither political nor polemical: it is technical, illustrating by example how alternatives can be developed and used and providing useful advice on developing others. After looking at the reasons for and potential benefits of alternatives to animal experiments, the book covers a range of methods and examples emphasising the design considerations that went into each system. The chapters also include 'case studies' that illustrate the ways in which culture models can be used to answer a range of important biological questions of direct relevance to human development, physiology, disease and healing."--
    Note: Includes index. , Potential advantages of using biomimetic alternatives / Jamie Davies -- Overview of biomimetic alternatives / Jamie Davies -- Pancreatic islands / Eli C. Lewis -- Endometrial organoid culture / Merja Blauer -- Modelling lymphatic and blood capillary patterning / Francoise Bruyere [and others] -- Precision-cut lung slices (PCLS) / Christian Martin and Stefan Uhlig -- Human colon tissue in organ culture / Michael K. Dame and James Varani -- Fetal organs culture / Jamie Davies -- Design of a mechanical loading device to culture intact bovine spinal motion segments under multiaxial motion / Jochen Walser, Stephen John Ferguson, and Benjamin Gantenbein-Ritter -- Magnetic assembly of tissue surrogates / Chien-Yu Fu and Hwan-You Chang -- Assembly of renal tissues by cellular self-organization / Mathieu Unbekandt -- Hierarchical screening of pathways: using cell and organ cultures to reduce use of transgenic mice / Guangping Tai and Jamie Davies -- Lung organoid culture to study response to viruses / Wenxin Wu, J. Leland Booth, and Jordan P. Metcalf -- Organ-cultured human skin for the study of epithelial cell invasion of stroma / James Varani -- Organotypic mandibular cultures for the study of inflammatory bone pathology / Alastair J. Sloan, Sarah Y. Taylor, and Emma L. Smith -- Three-dimensional, high-density and tissue engineered culture models of articular cartilage / Ali Mobasheri [and others] -- Concluding remarks / Jamie Davies.
    Additional Edition: Print version: Replacing animal models. Chichester, West Sussex : John Wiley & Sons, 2012 ISBN 9781118231784
    Language: English
    Keywords: Electronic books.
    URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781119940685
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    FU Berlin
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