Umfang:
Online-Ressource (XV, 250 p. 29 illus., 28 illus. in color, digital)
ISBN:
9781461458944
,
1283911779
,
9781283911771
Serie:
Advances in Experimental Medicine and Biology 777
Inhalt:
Since its first description fifteen years ago as a novel antigen of neural and hematopoietic stem cells, prominin-1 (alias CD133) has emerged concomitantly with stem and cancer stem cell research as an essential cell surface marker allowing identification and isolation of cells with stem cell properties. Although the physiological function of prominin-1 and the other members of prominin family remains elusive, its study has revealed new biological features regarding stem cells, cancer stem cells and photoreceptors. The latter cell type is illustrated by the association of mutations in prominin-1 (PROM1) gene with retinal degenerations including Stargardt-like macular dystrophy and retinitis pigmentosa. This book discusses these issues with contributions from leading experts in molecular and cellular biology, stem cells and tissue engineering. It also covers the potential role of prominin-1-positive stem cells in regenerative medicine, and its use as a biomarker of cancers originating from various organ systems and/or molecular target in cancer stem cell therapy. This book is an essential concise guide to the latest discoveries on prominin-1 and the applications in various medical research fields such as stem and cancer stem cells. Denis Corbeil holds a PhD in Biochemistry (University of Montreal, Canada). He is head of Tissue Engineering Laboratories, Biotechnological Centre (BIOTEC), Technische Universität Dresden, Dresden, Germany.
Anmerkung:
Description based upon print version of record
,
Prominin-1 (CD133): NewInsights on Stem & Cancer Stem Cell Biology; Preface; Contents; Contributors; Part I: Biology of Prominins; Chapter 1: Prominin-1 (CD133): Molecular and Cellular Features Across Species; 1.1 Introduction; 1.2 Identi fi cation of Prominin-1; 1.3 Protein Features; 1.4 Genes, Splice Variants, and Glycoforms; 1.4.1 Genomic Organization; 1.4.2 Prominin-1 Splice Variants; 1.4.3 Glycoforms; 1.5 Cellular Features of Prominin-1; 1.6 Differentiated Cells, Stem Cells, and Cancer Stem Cells; 1.6.1 Differentiated Cells: Widespread Distribution; 1.6.2 Stem Cells
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1.6.3 Cancer Stem Cells1.7 Function of Prominin-1; 1.8 Concluding Remarks and Perspectives; References; Chapter 2: Prominin-2 and Other Relatives of CD133; 2.1 Introduction; 2.2 Protein and Gene Structure of Prominin-2; 2.3 Cell Biology of Prominin-2; 2.3.1 Subcellular Localization; 2.3.2 Cholesterol Binding and Membrane Microdomain; 2.3.3 Membrane Vesicles; 2.4 Prominin-2 Expression; 2.4.1 Tissue Distribution; 2.4.2 Regulation of Prominin-2 Expression; 2.4.3 Prominin-2 and Cancer; 2.5 Evolution of the Prominin Gene Family; 2.6 Conclusions; References
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Chapter 3: Prominin-1-Containing Membrane Vesicles: Origins, Formation, and Utility3.1 Introduction; 3.2 Prominin-1; 3.3 Prominin-1-Containing Membrane Vesicles: What Are They?; 3.3.1 Prominin-1-Containing Membrane Vesicles from Stem Cells; 3.3.2 Prominin-1-Containing Membrane Vesicles from Body Fluids; 3.4 Biogenesis of Prominin-1-Containing Membrane Vesicles; 3.4.1 Subcellular Origins; 3.4.2 Molecular Mechanisms of Prominin-1-Containing Membrane Vesicle Release; 3.4.2.1 Release of P4 Type of Membrane Vesicles; 3.4.2.2 Release of P2 Type of Membrane Vesicles; 3.5 Physiological Role
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3.5.1 Embryonic Development of the Central Nervous System3.5.2 Cellular Differentiation; 3.5.3 Membrane Vesicles in Tumorigenesis and Other Diseases; 3.6 Conclusion and Outlook; References; Chapter 4: Prominent Role of Prominin in the Retina; 4.1 Mammalian Prominin; 4.2 Prominin-1 and the Mammalian Visual System; 4.2.1 Retinal Dystrophies: Mutations in PROM1; 4.2.2 Photoreceptor Morphogenesis; 4.3 Prominin-1 in Non-mammalian Vertebrate Eyes; 4.4 Prominin in Fly Eyes; 4.4.1 The Organization of the Fly Retina; 4.4.2 Fly Photoreceptor Morphogenesis
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4.4.3 Role of Prominin in Photoreceptor Morphogenesis4.5 Outlook; References; Chapter 5: Gene Regulation of Prominin-1 (CD133) in Normal and Cancerous Tissues; 5.1 Introduction; 5.2 Prominin-1 Gene Structure; 5.3 Prominin-1 in Normal Stem Cells; 5.4 Prominin-1 in Cancer Stem Cells; 5.5 PROM1 Gene Regulation; 5.5.1 DNA Hypomethylation; 5.5.2 Transcriptional Factors (SOX17, AF4, and ETS); 5.5.3 Hypoxia; 5.5.4 Iron; 5.5.5 Low Mitochondrial Activity; 5.6 Conclusion; References; Part II: Prominin-1/CD133 and Stem Cells
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Chapter 6: Prominin-1 (CD133) and the Cell Biology of Neural Progenitors and Their Progeny
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Preface -- Prominin-1 (CD133): Molecular and Cellular Features Across Species -- Prominin-2 and Other Relatives of CD133 -- Prominin-1-containing Membrane Vesicles: Origins, Formation and Utility -- Prominent Role of Prominin in the Retina -- Gene Regulation of Prominin-1 (CD133) in Normal and Cancerous Tissues -- Prominin-1 (CD133) and the Cell Biology of Neural Progenitors and Their Progeny -- CD133-Positive Hematopoietic Stem Cells: From Biology to Medicine -- New Insights into the Renal Progenitor Cells and Kidney Diseases by Studying CD133 -- CD133 Expression Strongly Correlates with the Phenotype of Very Small Embryonic/Epiblast-like Stem Cells -- New Insights into the CD133 (Prominin-1) Expression in Mouse and Human Colon Cancer Cells -- Prominin-1 (CD133) Expression in the Prostate and Prostate Cancer: A Marker for Quiescent Stem Cells -- Prominin-1 (CD133) Reveals New Faces of Pancreatic Progenitor Cells and Cancer Stem Cells: Current Knowledge and Therapeutic Perspectives -- Prominin-1 (CD133) and Metastatic Melanoma: Current Knowledge and Therapeutic Perspectives -- CD133-Positive Cells for Cardiac Stem Cell Therapy: Current Status and Outlook -- CD133+ Cells for the Treatment of Degenerative Diseases: Update and Perspectives -- Index.
Weitere Ausg.:
ISBN 9781461458937
Weitere Ausg.:
Buchausg. u.d.T. Corbeil, Denis Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology New York, NY : Springer, 2013 ISBN 9781461458937
Sprache:
Englisch
Fachgebiete:
Biologie
DOI:
10.1007/978-1-4614-5894-4
URL:
Volltext
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