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  • 1
    UID:
    edochu_18452_13953
    ISSN: 1437-4331 , 1437-4331
    Content: One hundred sera from intensive care patients, and 93 sera from endocrinological outpatients were used for a comparison between two automated assays for free triiodothyronine (Enzymun Test, and Elecsys 2010, both Boehringer Mannheim, Mannheim, Germany). In outpatients a good correlation between both methods was found (r=0.932). In contrast, comparability between the two assays was poor in intensive care patients (r=0.75, after exclusion of two outliers); significantly more values in the hypothyroid range were found with the Elecsys 2010 assay (n=83, compared with n=33 with the Enzymun Test; x2 test p=0.001). We conclude that routine measurement of free triiodothyronine which has the theoretical advantage of quantifying the biologically active fraction of thyroid hormones may have methodological limitations in severely ill patients.
    Content: Peer Reviewed
    In: Clinical Chemistry and Laboratory Medicine, : de Gruyter, 2009, 35,1997,11, Seiten 873-876, 1437-4331
    Language: English
    URL: Volltext  (kostenfrei)
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  • 2
    UID:
    edochu_18452_18836
    Format: 1 Online-Ressource (10 Seiten)
    ISSN: 1877-5845 , 1877-5845
    Content: The transmission of dengue disease is influenced by complex interactions among vector, host and virus. Land use such as water bodies or certain agricultural practices have been identified as likely risk factors for dengue because of the provision of suitable habitats for the vector. Many studies have focused on the land use factors of dengue vector abundance in small areas but have not yet studied the relationship between land use factors and dengue cases for large regions. This study aims to clarify if land use factors other than human settlements, e.g. different types of agricultural land use, water bodies and forest are associated with reported dengue cases from 2008 to 2010 in the state of Selangor, Malaysia. From the correlative relationship, we aim to generate a prediction risk map. We used Boosted Regression Trees (BRT) to account for nonlinearities and interactions between the factors with high predictive accuracies. Our model with a cross-validated performance score (Area Under the Receiver Operator Characteristic Curve, ROC AUC) of 0.81 showed that the most important land use factors are human settlements (model importance of 39.2%), followed by water bodies (16.1%), mixed horticulture (8.7%), open land (7.5%) and neglected grassland (6.7%). A risk map after 100 model runs with a cross-validated ROC AUC mean of 0.81 (±0.001 s.d.) is presented. Our findings may be an important asset for improving surveillance and control interventions for dengue.
    Content: Peer Reviewed
    Note: Die Zweitveröffentlichung der Publikation wurde durch Studierende des Projektseminars "Open Access Publizieren an der HU" im Sommersemester 2017 betreut. Nachgenutzt gemäß den CC-Bestimmungen des Lizenzgebers bzw. einer im Dokument selbst enthaltenen CC-Lizenz.
    In: Spatial and Spatio-temporal Epidemiology, : Elsevier, 10,2014, Seiten 75-84, 1877-5845
    Language: English
    URL: Volltext  (kostenfrei)
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  • 3
    UID:
    gbv_1850880115
    ISSN: 1473-5695
    Content: Objectives - In emergency departments (EDs), overcrowding, workload complexity, and cost containment represent current operational problems. In this retrospective observational study, we analyzed the effects of a professional quality management (QM) system on patient flow, diagnostic validity, and hospital costs. Materials and methods - In 2005/2006, the main ED at the University Medical Center Goettingen was reorganized. A professional QM system according to DIN EN ISO 9001:2008 was introduced in 2008. In a retrospective observational study, we compared the number of cases, the spectrum of clinical diagnoses, the validity of diagnoses, and hospital costs in the ED before (2005) and 2 years after the introduction of the QM system (2010). Results - In the ED at the University Medical Center Goettingen, the number of cases increased by 22.7% between 2005 and 2010. After the introduction of the QM system, a significant reduction in patients’ length of stay within the ED was achieved (P〈0.001). Furthermore, the rate of diagnostic errors for patients assigned for admission within the ED could be reduced significantly (P=0.002). A reduction of patient-related hospital costs of 8.9% was achieved by restriction of diagnostic tests according to standard operating procedures for each emergency diagnosis. Conclusion - The introduction of a professional QM system in EDs improves patient flow as well as quality of medical care and results in a significant reduction in hospital costs. Further analyses should evaluate the effects of QM on quality indicators in a prospective multicenter study. Validation of results has to be performed in a dynamic model for process simulation.
    In: European journal of emergency medicine, London : Lippincott, Williams & Wilkins, 1994, 21(2014), 2, Seite 98-104, 1473-5695
    In: volume:21
    In: year:2014
    In: number:2
    In: pages:98-104
    Language: English
    URL: Volltext  (lizenzpflichtig)
    Author information: Blaschke, Sabine
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