Kooperativer Bibliotheksverbund

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Format: 1 online resource (164 pages)

Edition: 1st ed.

ISBN: 9783031579608

Series Statement: SpringerBriefs in Archaeology Series

Note: Intro -- Foreword -- Contents -- Abbreviations -- Chapter 1: Potentially Polluting Wrecks: An Introduction -- 1.1 Overview -- 1.2 RUST, RULET, and the Potentially Polluting Wrecks Study -- 1.3 Site Assessment and Pollution Risk Remediation -- 1.4 Protecting Our Ocean Heritage -- References -- Chapter 2: Potentially Polluting Wrecks and the Legal Duty to Protect Our Ocean Heritage -- 2.1 Introduction -- 2.2 The Initial Evolution of a Duty to Protect Our Ocean Heritage -- 2.2.1 1972 Stockholm Declaration -- 2.2.2 The World Heritage Convention Integrating the Conservation of Cultural and Natural Heritage -- 2.3 The 1982 Law of the Sea Convention: The General Legal Framework for Managing PPWs -- 2.3.1 General Provisions on the Duty to Protect the Marine Environment and PPWs -- 2.3.2 Articles Protecting Cultural Heritage Found at Sea (303) and in the Area (149) -- 2.4 Maritime Law Conventions and the Ocean Heritage: The IMO Endeavours -- 2.4.1 Natural Disasters by Human Activities -- 2.4.2 Cultural Disasters by Human Greed -- 2.4.3 The Wreck Removal Convention -- 2.5 A New Approach to Ocean Heritage -- 2.5.1 The Precautionary Approach as a Guide to Manage PPWs as UCH -- 2.5.2 2001 Convention on the Protection of Underwater Cultural Heritage -- 2.5.3 The Question of PPWs Which Are Both UCH and Warships or Other States Vessels -- 2.6 Conclusion -- References -- Chapter 3: Environmental Impact and Modeling of Petroleum Spills -- 3.1 Introduction -- 3.2 Background -- 3.3 Previous Work -- 3.4 Released Oil -- 3.5 Computational Spill Models -- 3.6 Acute Biological Effects -- 3.7 Seasonal Considerations -- 3.8 Validation Studies -- 3.9 Stochastic Assessments -- 3.10 Conclusions -- References -- Chapter 4: Corrosion Processes of Steel-Hulled Potentially Polluting Wrecks -- 4.1 Overview -- 4.2 Corrosion Types in Shipwrecks. , 4.3 OCP and General Corrosion Factors -- 4.4 Acute Environmental Factors -- 4.5 Cyclical Environmental Factors -- 4.6 Long-Term Environmental Factors -- 4.7 Anthropogenic Factors -- 4.8 Ship Construction, Condition, Impact, and Orientation -- 4.9 A History of Shipwreck Corrosion Analysis -- 4.10 Case Study: USS Arizona -- 4.11 Conclusion -- References -- Chapter 5: From Desktop to Dive: Assessing the Pollution Potential of SS Fernstream, USNS Mission San Miguel and SS Coast Trader -- 5.1 Introduction -- 5.2 SS Fernstream -- 5.3 USNS Mission San Miguel -- 5.4 SS Coast Trader -- 5.5 Conclusion -- References -- Chapter 6: Managing Potentially Polluting Wrecks in the United Kingdom -- 6.1 The Inception of Wreck Management in the UK -- 6.2 Current Wreck Management in the UK -- 6.3 Distribution of British PPW -- 6.4 Wreck Survey Techniques -- 6.5 Case Studies -- 6.5.1 RFA Darkdale -- 6.5.2 RFA War Mehtar -- 6.5.3 SS Derbent -- 6.5.4 HMS Prince of Wales and HMS Repulse -- 6.6 Summary -- References -- Chapter 7: Polluting Wrecks in the Baltic Sea -- 7.1 Introduction -- 7.2 History of Operations -- 7.3 Wrecks in the Baltic Region -- 7.4 Sweden -- 7.5 Finland -- 7.6 Russia -- 7.7 Estonia -- 7.8 Latvia -- 7.9 Lithuania -- 7.10 Poland -- 7.11 Germany -- 7.12 Denmark -- 7.13 Wreck Risk Assessment Methods -- 7.14 Case Studies of the Stuttgart and Franken Wrecks -- 7.14.1 SS Stuttgart -- 7.15 Supply Vessel Franken (Trossschiff Franken) -- 7.16 Conclusion -- References -- Chapter 8: Potentially Polluting Wrecks in the Blue Pacific -- 8.1 Introduction to Potentially Polluting Wrecks in the Pacific -- 8.2 History of PPW Management in the Pacific -- 8.3 U.S Government PPW Interventions in the Pacific -- 8.4 USS Mississinewa -- 8.5 Ex-USS Chehalis -- 8.6 Ex-USS Prinz Eugen -- 8.7 Japanese Government Interventions in the Pacific. , 8.8 Current Situation of PPW in the Pacific -- 8.9 Case Study: Potentially Polluting Wrecks in Chuuk Lagoon -- 8.10 The FSM WWII Shipwreck Pollution Mitigation Project -- 8.11 Lessons and Conclusions -- References -- Chapter 9: Satellite Detection and the Discovery of Bloody Marsh -- 9.1 Introduction -- 9.2 SS Bloody Marsh -- 9.3 Initial Expedition -- 9.4 Satellite Detection of Sea Surface Oil Slicks -- 9.5 Oil Slick Evidence Towards Bloody Marsh Wreck Location -- 9.6 Discovery -- 9.7 Discussion and Conclusion -- References -- Chapter 10: Searching for a Lost PPW: SS William Rockefeller -- 10.1 Introduction -- 10.2 Why Bayesian Search? -- 10.3 Searching for Rockefeller -- 10.4 Conclusion -- References -- Chapter 11: Assessment Methodologies for Potentially Polluting Wrecks: The Need for a Common Approach -- 11.1 Introduction -- 11.2 Current Status of Wreck Assessment Methods -- 11.3 Our Experience in the Assessment of Potentially Polluting Wrecks -- 11.4 Case Study: Tug Simson -- 11.4.1 Case Study: Emergency Response Assessment -- 11.5 Wreck Assessment Methodologies-The Future -- References -- Chapter 12: Concluding Statement.

Additional Edition: Print version: Brennan, Michael L. Threats to Our Ocean Heritage: Potentially Polluting Wrecks Cham : Springer,c2024 ISBN 9783031579592

Language: English

Keywords: Electronic books.

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URL: lizenzpflichtig

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Format: 1 Online-Ressource (454 Seiten)

Edition: 3rd ed

ISBN: 9783648152454

Series Statement: Haufe Fachbuch

Note: Description based on publisher supplied metadata and other sources , Intro -- Inhaltsverzeichnis -- Hinweis zum Urheberrecht -- Impressum -- Grußwort des Verbandes der Immobilienverwalter Deutschland (VDIV) -- Vorwort der Vonovia Immobilien Treuhand -- Vorwort der Autoren -- Abkürzungsverzeichnis -- 1 Der Verwalter -- 1.1 Auf der Suche nach einem neuen Verwalter -- 1.2 Die Person des Verwalters - wer darf überhaupt »verwalten«? -- 1.3 Die Qualifikation des Verwalters -- 1.4 Welche Gesetze muss der Verwalter kennen? -- 1.5 Für welchen Zeitraum kann ein Verwalter bestellt werden? -- 1.6 Vorsicht bei der Formulierung des Bestellungsbeschlusses -- 1.7 Der Verwaltervertrag: Was regelt der Vertrag? -- 1.8 Wer darf den Verwaltervertrag unterschreiben? -- 1.9 Der Verwaltervertrag: Was ist eine »AGB-Inhaltskontrolle«? -- 1.10 Welche Vergütungen darf der Verwalter vereinbaren? -- 1.11 Bescheinigung gem. 35a EStG als besondere Leistung? -- 1.12 Wann ist die Verwaltervergütung fällig? -- 1.13 Vorsicht bei »Verträgen zulasten Dritter«! -- 1.14 Sind Vergleichsangebote bei der Verwalterbestellung notwendig? -- 1.15 Stimmrechtsverbot bei der Verwalterbestellung -- 1.16 Stimmrechtsverbot bei Verwalterbestellung bei Vorliegen von Vollmachten -- 1.17 Der Versammlungsleiter bei juristischen Personen -- 1.18 Darf der Verwalter das Grundbuch einsehen? -- 1.19 Gibt es eine Pflicht zur Übersendung von Verwaltungsunterlagen? -- 1.20 Welche Auskunftspflichten treffen den Verwalter? -- 1.21 Beschlussumsetzung -- 1.22 Darf der Verwalter Provisionen vereinnahmen? -- 1.23 Wiederbestellung vergessen - was nun? -- 1.24 Verwalterwechsel: Wer ist für die Erstellung der Jahresabrechnung zuständig? -- 1.25 Der Verwalter als Makler: Vermittlung von Mietwohnungen? -- 1.26 Der Verwalter als Makler: Verkauf und Verwalterzustimmung -- 1.27 Der Verwalter als Baufachmann? -- 1.28 Muss der Verwalter eine Fördermittelberatung durchführen? , 1.29 Kontoführung in der WEG (Legitimation) -- 1.30 Kann der Verwalter seine Immobilienverwaltung verkaufen? -- 1.31 Datenschutz in der WEG - was darf der Verwalter mitteilen? -- 1.32 Hat der Verwalter einen Anspruch auf Entlastung? -- 1.33 Darf der Verwalter Unterlagen der WEG vernichten? -- 1.34 Digitale Beleg- bzw. Rechnungsprüfung? -- 1.35 Keine außerordentliche Abberufung des Verwalters mehr? -- 1.36 Kann der Verwalter sein Amt auch niederlegen? -- 2 Die Vertretung der Wohnungseigentümergemeinschaft -- 2.1 Die Vertretungsmacht des Verwalters im Außenverhältnis -- 2.2 Die Vertretungsmacht des Verwalters im Innenverhältnis -- 2.3 Maßnahmenkatalog durch Beschluss -- 2.4 Beiratsvorsitzender oder Eigentümer als Vertreter -- 2.5 Kompetenzüberschreitung und Haftung des Verwalters -- 2.6 Die Abwicklung von Versicherungsschäden -- 2.7 Die Beauftragung eines Rechtsanwalts in Passivprozessen -- 2.8 Die Beauftragung eines Rechtsanwalts in Aktivprozessen und Vergütungsvereinbarung -- 2.9 Die verwalterlose WEG -- 3 Verkehrssicherung -- 3.1 Die Erfüllung der Verkehrssicherungspflicht und die Haftung -- 3.2 Kann die Verkehrssicherungspflicht übertragen werden? -- 4 Die Wohnungseigentümer und andere Beteiligte -- 4.1 Der Wohnungseigentümer -- 4.2 Die Haftung des Wohnungseigentümers im Außenverhältnis -- 4.3 Notgeschäftsführung - welche Rechte hat der Eigentümer? -- 4.4 Angemessener Ausgleich für Beschädigungen am Sondereigentum -- 4.5 Wann hat der Eigentümer Anspruch auf Schadensersatz? -- 4.6 Der Anspruch des Eigentümers auf ordnungsmäßige Verwaltung -- 4.7 Ist eine Erhaltungsmaßnahme durch den Eigentümer ohne Beschluss möglich? -- 4.8 Können die Vorschüsse (Hausgeld) gekürzt werden (hier: Verwaltervergütung)? -- 4.9 Muss die WEG zwingend einen Verwaltungsbeirat bestimmen? -- 4.10 Wie viele Personen dürfen in den Verwaltungsbeirat gewählt werden? , 4.11 Was darf der Verwaltungsbeirat entscheiden? -- 4.12 Wann haftet der Verwaltungsbeirat? -- 4.13 Sonderausschüsse in der WEG-Verwaltung? -- 4.14 Kann ein Mieter Verwaltungsbeirat werden? -- 4.15 Darf dem Verwaltungsbeirat ein Gehalt gezahlt werden? -- 4.16 Wer bestimmt den Vorsitzenden des Verwaltungsbeirats? -- 4.17 Können nur natürliche Personen in den Verwaltungsbeirat gewählt werden? -- 4.18 Wie lange ist der Verwaltungsbeirat im Amt? -- 4.19 Muss der Verwaltungsbeirat auch entlastet werden? -- 4.20 Ist der Zwangsverwalter ein neuer Eigentümer? -- 4.21 Die Abschaffung des Ersatzzustellungsvertreters -- 4.22 Duldungspflichten Dritter -- 5 Eigentümerwechsel -- 5.1 Der Regelfall -- 5.2 Der Erbfall -- 5.3 Die Zwangsversteigerung -- 5.4 Ist ein Erwerber an Beschlüsse gebunden? -- 5.5 Ist ein Erwerber an Vereinbarungen gebunden? -- 5.6 Veräußerungszustimmung - wichtige Gründe -- 5.7 Veräußerungszustimmung - Delegation an die Eigentümer -- 5.8 Veräußerungszustimmung - Zeitpunkt der Zustimmungserteilung -- 5.9 Eigentümerwechsel - wie ist mit den angepassten Vorschüssen der erstellten Jahresabrechnung umzugehen? -- 5.10 Eigentümerwechsel - muss eine anteilige Jahresabrechnung erstellt werden? -- 6 Die Lehre von den Beschlüssen -- 6.1 Die Jahrhundertentscheidung des BGH -- 6.2 Beschlusskompetenz: Leistungspflichten -- 6.3 Beschlusskompetenz: Verbot der Tierhaltung? -- 6.4 Beschlusskompetenz: Stimmrechtsausschluss bei Hausgeldrückstand? -- 6.5 Beschlusskompetenz: Mitspracherecht des Eigentümers -- 6.6 Beschlusskompetenz: Umzugskostenpauschale -- 6.7 Der »Tod« der Öffnungsklausel: Belastungsverbot -- 6.8 Abdingbarkeit von Stimmenmehrheiten möglich? -- 6.9 Der Umlaufbeschluss - wie praxistauglich ist er? -- 6.10 Der Umlaufbeschluss - mit einfacher Mehrheit möglich? -- 6.11 Woraus ergeben sich die Beschlusskompetenzen und -mehrheiten im WEG? , 6.12 Anfechtung von Beschlüssen - ein Monat sind nicht vier Wochen -- 6.13 Der Zweitbeschluss -- 6.14 Beschlusskompetenz: Instandsetzung von Fenstern -- 6.15 Ist eine Änderung der Gemeinschaftsordnung durch Beschluss möglich? -- 6.16 Öffnungsklausel in der Gemeinschaftsordnung -- 6.17 Öffnungsklausel - Eintragung von Beschlüssen in das Grundbuch? -- 6.18 Öffnungsklausel - Berechnung der Mehrheit? -- 6.19 »Vergemeinschaftung« von Ansprüchen durch Beschluss -- 6.20 Die Beschluss-Sammlung -- 7 Die Eigentümerversammlung -- 7.1 Einladungsfrist: Drei Wochen sind nicht drei Wochen! -- 7.2 Wer lädt zur Eigentümerversammlung ein? -- 7.3 Ein Nichtberechtigter lädt zur Eigentümerversammlung ein - was nun? -- 7.4 Wer muss zur Eigentümerversammlung eingeladen werden? -- 7.5 Die nicht unterschriebene Einladung zur Eigentümerversammlung -- 7.6 Die Einladung wird nicht zugestellt - was nun? -- 7.7 Ist eine außerordentliche Eigentümerversammlung kostenlos? -- 7.8 Die Uhrzeit der Eigentümerversammlung -- 7.9 Der Ort der Eigentümerversammlung -- 7.10 Eigentümerversammlung in der Wohnung des Verwalters? -- 7.11 Darf die Eigentümerversammlung im Biergarten stattfinden? -- 7.12 Wer führt den Versammlungsvorsitz? -- 7.13 Bye-bye Beschlussfähigkeit -- 7.14 Vorsicht bei Stimmrechtsverboten -- 7.15 Abstimmung: Kann eine abgegebene Stimme zurückgezogen werden? -- 7.16 Abstimmung: Welche Abstimmungsmethoden gibt es? -- 7.17 Muss das Abstimmungsergebnis rechnerisch protokolliert werden? -- 7.18 Enthaltungen - sind das Ja- oder Nein-Stimmen? -- 7.19 Störender Wohnungseigentümer - ist ein Versammlungsausschluss möglich? -- 7.20 Darf der Mieter an der Eigentümerversammlung teilnehmen? -- 7.21 Darf ein Berater bei der Eigentümerversammlung anwesend sein? -- 7.22 Die Tagesordnung -- 7.23 Die Tagesordnung - ist das Nachschieben von Tagesordnungspunkten zulässig? , 7.24 Wie viele Tagesordnungspunkte muss der Verwalter aufnehmen? -- 7.25 Namentliche Abstimmung - aber wann? -- 7.26 Kann sich der Eigentümer von einer beliebigen Person auf der Versammlung vertreten lassen? -- 7.27 Muss zur Eigentümerversammlung eine schriftliche Vollmacht vorgelegt werden? -- 7.28 Müssen sich Ehegatten gegenseitig für die Eigentümerversammlung bevollmächtigen? -- 7.29 Wie viele Vollmachten darf man eigentlich vergeben? -- 7.30 Der Eigentümer als Vollmachtgeber und gleichzeitig Vollmachtnehmer? -- 7.31 Welches Stimmrechtsprinzip gilt? -- 7.32 Versendung der Niederschrift - aber bis wann? -- 7.33 Die Niederschrift - Ergebnis- oder Verlaufsprotokoll? -- 7.34 Wer muss die Niederschrift unterzeichnen? -- 7.35 Unterschriften im Falle einer Doppelfunktion -- 7.36 Verwalternachweis (und qualifizierte Protokollierklausel) -- 7.37 Funktionsbezeichnung in der Niederschrift -- 7.38 Ist auch ein Nachweis für den Vorsitzenden des Beirats notwendig? -- 7.39 Wann besteht ein Anspruch auf Berichtigung der Niederschrift? -- 7.40 Formfehler - ist eine »Heilung« möglich? -- 7.41 Online-Teilnahme an der Eigentümerversammlung? -- 8 Die Finanzen der WEG -- 8.1 Die Kostenverteilung -- 8.2 Änderung des Kostenverteilerschlüssels -- 8.3 Änderung der Kostenverteilung für die Erhaltung der Fenster -- 8.4 Die Öffnungsklausel -- 8.5 Individuelle Pflichten über die GO -- 8.6 Abweichungen von der Heizkostenverordnung -- 8.7 Wirtschaftsplan -- 8.8 Wirtschaftsplan - und die Fälligkeit -- 8.9 Fortgeltung der Vorschüsse -- 8.10 Die Sonderumlage -- 8.11 Die Darlehensaufnahme -- 8.12 Die Kontenführung -- 8.13 Die Jahresabrechnung - Beschlussinhalt -- 8.14 Der Inhalt der Jahresabrechnung -- 8.15 Die Erhaltungsrücklage -- 8.16 Der Umgang mit den Rechtsanwalts- und Verfahrenskosten -- 8.17 Sonderkosten und Einzelbelastung , 8.18 Die bedingte Genehmigung der Anpassung der Vorschüsse

Additional Edition: Erscheint auch als Druck-Ausgabe Füllbeck, Massimo Praxisfälle für WEG-Verwalter Freiburg : Haufe Lexware Verlag,c2021 ISBN 9783648152447

Language: German

Subjects: Economics

Keywords: Deutschland ; Verwalter ; Wohnungseigentum

URL: Volltext  (URL des Erstveröffentlichers)

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Format: 1 online resource (xi, 327 pages) : , digital, PDF file(s).

Edition: 1st ed.

ISBN: 1-108-67051-2 , 1-108-64008-7

Series Statement: Physical Sciences

Content: Instabilities are present in all natural fluids from rivers to atmospheres. This book considers the physical processes that generate instability. Part I describes the normal mode instabilities most important in geophysical applications, including convection, shear instability and baroclinic instability. Classical analytical approaches are covered, while also emphasising numerical methods, mechanisms such as internal wave resonance, and simple `rules of thumb' that permit assessment of instability quickly and intuitively. Part II introduces the cutting edge: nonmodal instabilities, the relationship between instability and turbulence, self-organised criticality, and advanced numerical techniques. Featuring numerous exercises and projects, the book is ideal for advanced students and researchers wishing to understand flow instability and apply it to their own research. It can be used to teach courses in oceanography, atmospheric science, coastal engineering, applied mathematics and environmental science. Exercise solutions and MATLAB® examples are provided online. Also available as Open Access on Cambridge Core.

Note: Title from publisher's bibliographic system (viewed on 19 Apr 2019). , Cover -- Half-title page -- Title page -- Copyright page -- Contents -- Preface -- Acknowledgments -- Part I Normal Mode Instabilities -- 1 Preliminaries -- 1.1 What Is Instability? -- 1.2 Goals -- 1.3 Tools -- 1.4 Numerical Solution of a Boundary Value Problem -- 1.5 The Equations of Motion -- 1.6 Further Reading -- 1.7 Appendix: A Closer Look at Perturbation Theory -- 2 Convective Instability -- 2.1 The Perturbation Equations -- 2.2 Simple Case: Inviscid, Nondiffusive, Unbounded Fluid -- 2.3 Viscous and Diffusive Effects -- 2.4 Boundary Effects: the Rayleigh-Benard Problem -- 2.5 Nonlinear Effects -- 2.6 Summary -- 2.7 Appendix: Waves and Convection in a Compressible Fluid -- 3 Instabilities of a Parallel Shear Flow -- 3.1 The Perturbation Equations -- 3.2 Rayleigh's Equation -- 3.3 Analytical Example: the Piecewise-Linear Shear Layer -- 3.4 Solution Types for Rayleigh's Equation -- 3.5 Numerical Solution of Rayleigh's Equation -- 3.6 Shear Scaling -- 3.7 Oblique Modes and Squire Transformations -- 3.8 Rules of Thumb for a General Shear Instability -- 3.9 Numerical Examples -- 3.10 Perturbation Energetics -- 3.11 Necessary Conditions for Instability -- 3.12 The Wave Resonance Mechanism of Shear Instability -- 3.13 Quantitative Analysis of Wave Resonance -- 3.14 Summary -- 3.15 Appendix: Classical Proof of the Rayleigh and Fjørtoft Theorems -- 3.16 Further Reading -- 4 Parallel Shear Flow: the Effects of Stratification -- 4.1 The Richardson Number -- 4.2 Equilibria and Perturbations -- 4.3 Oblique Modes -- 4.4 The Taylor-Goldstein Equation -- 4.5 Application to Internal Wave Phenomena -- 4.6 Analytical Examples of Instability in Stratified Shear Flows -- 4.7 The Miles-Howard Theorem -- 4.8 Howard's Semicircle Theorem -- 4.9 Energetics -- 4.10 Summary -- 4.11 Further Reading -- 4.12 Appendix: Veering Flows -- 4.13 Appendix: Spatial Growth. , 5 Parallel Shear Flow: the Effects of Viscosity -- 5.1 Conditions for Equilibrium -- 5.2 Conditions for Quasi-Equilibrium: the Frozen Flow Approximation -- 5.3 The Orr-Sommerfeld Equation -- 5.4 Boundary Conditions for Viscous Fluid -- 5.5 Numerical Solution of the Orr-Sommerfeld Equation -- 5.6 Oblique Modes -- 5.7 Shear Scaling and the Reynolds Number -- 5.8 Numerical Examples -- 5.9 Perturbation Energetics in Viscous Flow -- 5.10 Summary -- 6 Synthesis: Viscous, Diffusive, Inhomogeneous, Parallel Shear Flow -- 6.1 Expanding the Basic Equations -- 6.2 Numerical Solution -- 6.3 2D and Oblique Modes: Squire Transformations -- 6.4 Shear and Diffusion Scalings -- 6.5 Application: Instabilities of a Stably Stratified Shear Layer -- 6.6 Application: Analysis of Observational Data -- 6.7 Summary -- 6.8 Further Reading -- 7 Nonparallel Flow: Instabilities of a Cylindrical Vortex -- 7.1 Cyclostrophic Equilibrium -- 7.2 The Perturbation Equations -- 7.3 Barotropic Modes (m = 0) -- 7.4 Axisymmetric Modes (l = 0) -- 7.5 Analytical Example: the Rankine Vortex -- 7.6 Numerical Example: a Continuous Vortex -- 7.7 Wave Interactions in Barotropic Vortices -- 7.8 Mechanisms of Centrifugal and Convective Instabilities -- 7.9 Swirling Flows -- 7.10 Summary -- 7.11 Further Reading -- 8 Instability in a Rotating Environment -- 8.1 Frontal Zones -- 8.2 Geostrophic Equilibrium and the Thermal Wind Balance -- 8.3 The Perturbation Equations -- 8.4 Energetics -- 8.5 The Vertical Vorticity Equation -- 8.6 Analytical Solution #1: Inertial and Symmetric Instabilities -- 8.7 Analytical Solution #2: Baroclinic Instability -- 8.8 Numerical Solution Method -- 8.9 Instability in the Ageostrophic Regime -- 8.10 Summary -- 8.11 Further Reading -- 9 Convective Instability in Complex Fluids -- 9.1 Conditional Instability in a Moist Atmosphere or a Freezing Ocean. , 9.2 Double Diffusive Instabilities -- 9.3 Bioconvection -- 9.4 CO[sub(2)] Sequestration -- 10 Summary -- 10.1 Equilibrium States -- 10.2 Instabilities -- Part II The View Ahead -- 11 Beyond Normal Modes -- 11.1 Instability as an Initial Value Problem -- 11.2 Transient Growth in Simple Linear Systems -- 11.3 Computing the Optimal Initial Condition -- 11.4 Optimizing Growth at t = 0[sup(+)] -- 11.5 Growth at Short and Long Times: a Simple Example -- 11.6 Example: The Piecewise Shear Layer -- 11.7 Mechanics of Transient Growth in a Shear Layer -- 11.8 Generalizing the Inner Product -- 11.9 Summary -- 11.10 Appendix: Singular Value Decomposition -- 11.11 Further Reading -- 12 Instability and Turbulence -- 12.1 Secondary Instabilities and the Transition to Turbulence -- 12.2 Turbulence-Driven Instabilities -- 12.3 Cyclic Instability -- 12.4 Further Reading -- 13 Refining the Numerical Methods -- 13.1 Higher-Order Finite Differences -- 13.2 Finite Differences on an Adaptive Grid -- 13.3 Galerkin Methods -- 13.4 The Shooting Method -- 13.5 Generalizations -- 13.6 Further Reading -- Appendix A Homework Exercises -- Appendix B Projects -- References -- Index. , English

Additional Edition: ISBN 1-108-70301-1

Language: English

Subjects: Geography

URL: Volltext  (kostenfrei)

URL: Inhaltstext

URL: https://www.cambridge.org/de/academic/subjects/earth-and-environmental-science/oceanography-and-marine-science/instability-geophysical-flows?format=AR

URL: https://doi.org/10.1017/9781108640084

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Format: 1 online resource (332 pages)

Edition: 1st ed.

ISBN: 1-78756-189-5 , 1-78756-187-9

Series Statement: Corporate ethics for turbulent markets

Content: The tapestry of human behaviour in the marketplace today is turbulent, unpredictable, and chaotic. Yet it is also so diverse, rich and global that it presents a rare ethical and moral opportunity, and challenge, to out-behave competition and create enduring value. This is corporate ethics for corporate advantage. Corporate Ethics for Turbulent Markets: The Market Context of Executive Decisions focuses on the HOW of doing business the economic, social, ethical, moral and spiritual values we bring to our business ventures - and how thereby we impact the world. The book focuses on the LEMS (legality, ethicality, morality, and spirituality) technique that we submit as a prescriptive benchmarking tool for all corporate thinking, deliberation, explanation, evaluation, choices, strategic implementation, accountability and moral responsibility. It demonstrates that by going beyond the legal obligation (legality) to do the "right thing" (ethicality), to do the "right thing rightly" (morality), and doing the "right thing rightly and for the right intentions" (spirituality), we can create a sure strategy for good decision making and implementation that can heal the world from its current addictions to corporate fraud in all its evil forms. Envisioning a moral reawakening, this book will challenge business students and executives alike to re-evaluate the moral justification of business choices, decisions, actions and their consequences. LEMS as a four-dimensional cross-checking skill for all that we think, do, become and be takes time and patience but it can surely heal an otherwise divided and broken world.

Note: Cover -- Title Page -- Copyright Page -- Acknowledgements -- Contents -- About the Author -- Prologue: Corporate Ethics for Turbulent Markets of Today -- Corporate Statesmen -- Critical Importance of Corporate Ethics Today -- Corporate Ethics through Real Current Business Cases -- The Structure of This Book -- The Target Audience -- The Uniqueness of This Book -- Notes -- Chapter 1 Characterizing Market Turbulence Today as a Source of Market Opportunity -- Executive Summary -- 1.1. Introduction -- 1.2. What Is Market Turbulence? -- 1.3. Tracking the Emergence of Economies, Their Market Turbulence, and Opportunity -- 1.4. Current Market Turbulence and Economic Chaos -- 1.5. Recent Major Factors that Generated Market Turbulence -- 1.5.1. Chinese Invasion of Global Markets -- 1.5.2. Global Climate Change and Policies -- 1.5.3. Brexit and Global Market Turbulence -- 1.5.4. Immigrant Populations and Global Refugee Crisis -- 1.5.5. Artificial Intelligence and Market Turbulence -- 1.6. Demonetization in India and Market Turbulence -- 1.6.1. Structure of Market Turbulence -- 1.6.2. Relevance of Corporate Ethics Under Market Turbulence Today -- 1.6.3. Market Turbulence as Market Certainty, Risk, Uncertainty, and Chaos -- 1.7. Market Turbulence as Buyer-Seller Information Asymmetry -- 1.7.1. Nature of Buyer-Seller Information Asymmetry -- 1.8. Concluding Remarks: Managerial Implications -- Notes -- Chapter 2 The Domain and Context of Corporate Ethics: Introducing Concepts and Directions -- Executive Summary -- 2.1. Introduction -- 2.2. Toward a Strong Positive Approach to Corporate Ethics -- 2.3. Conceptual versus Operational Definitions -- 2.4. What Is Spirituality? -- 2.5. What Is Morality? -- 2.6. What Is Ethicality? -- 2.7. What Is Legality? -- 2.8. What Are Values? -- 2.9. Business Ethics and Managerial Ethics -- 2.10. What Is Corporate Ethics?. , 2.11. Commonality Between Ethics, Business Ethics, and Corporate Ethics -- 2.12. Descriptive versus Prescriptive Ethics -- 2.13. Major Ethical Theories -- 2.14. The Ethical Theory of Teleology -- 2.15. The Ethical Theory of Deontology -- 2.16. The Ethical Theory of Distributive Justice -- 2.17. The Ethical Theory of Corrective Justice -- 2.18. Corporate Value Ethics -- 2.19. The Gray Area in Corporate Ethics -- 2.20. Methodology of Corporate Ethics -- 2.21. Legal, Ethical, Moral, and Spiritual Executive Conduct -- 2.22. The Dynamics of Corporate Ethics -- 2.23. Concluding Remarks -- Notes -- Chapter 3 A Systems Thinking Approach to Understand the Challenge of Corporate Ethics in the Turbulent Markets of Today -- Executive Summary -- 3.1. Introduction -- 3.2. What Is a System? -- 3.3. What Is Systems Thinking? -- 3.4. Market Turbulence Problem as a System at Unrest -- 3.5. Systems Thinking and Process Mapping -- 3.6. The Concept of Feedback -- 3.7. The Reinforcing and Balancing Feedback Processes -- 3.8. Free Enterprise Capitalism System -- 3.9. FECS as a System of Subjects, Objects, Properties, and Events -- 3.10. Critical Systems Thinking Questions for Corporate Ethics -- 3.10.1. Systemic Laws for Systems Thinking -- 3.10.1.1. Law 1: Today's Problems Come from Yesterday's Solutions -- 3.10.1.2. Law 2: The Harder You Push, the Harder the System Pushes Back -- 3.10.1.3. Law 3: Behavior Grows Better Before It Grows Worse -- 3.10.1.4. Law 4: The Easy Way Out Usually Leads Back In -- 3.10.1.5. Law 5: The Cure Can Be Worse than the Disease -- 3.10.1.6. Law 6: Faster Is Slower -- 3.10.1.7. Law 7: Cause and Effect Are Not Closely Related in Time or Space -- 3.10.1.8. Law 8: Small Changes Can Produce Big Results - but the Areas of Higher Leverage Are Often the Least Obvious -- 3.10.1.9. Law 9: You Can Have Your Cake and Eat It too - but Not All at Once. , 3.10.1.10. Law 10: Dividing an Elephant in Half Does Not Produce Two Elephants -- 3.10.1.11. Law 11: There Is No Blame -- 3.10.2. Archetypes of Systems Thinking: Nature's Templates That Control Human Events -- 3.10.2.1. Archetype 1: Limits to Growth -- 3.10.2.2. Archetype 2: Shifting the Burden -- 3.10.2.3. Archetype 3: "Fixes That Backfire" -- 3.10.2.4. Archetype 4: "Tragedy of the Commons" -- 3.10.2.5. Archetype 5: "Accidental Adversaries" -- 3.10.2.6. Archetype 6: "Success to the Successful" -- 3.10.2.7. Archetype 7: "Balancing Process with Delay" -- 3.10.2.8. Archetype 8: "Growth and Underinvestment" -- 3.10.2.9. Archetype 9: "Escalation" -- 3.10.2.10. Archetype 10: "Eroding Goals" -- 3.11. Concluding Remarks -- Notes -- Chapter 4 The Success of Free Enterprise Capitalist System When Designed and Deployed Rightly -- Executive Summary -- 4.1. Introduction -- Notes -- References -- 4.2. In Defense of Capitalism -- 4.3. What Is Capitalism? -- 4.4. Morality of Private Property -- 4.5. Hobbesian Capitalism -- 4.6. Adam Smith's Version of Capitalism -- 4.7. In Defense of Free Enterprise Capitalist System -- 4.8. Morality of Profits and Losses -- 4.9. Max Weber's Ethics of Capitalism -- 4.10. Welfare Capitalism or the Dependence Culture -- 4.11. Moral Issues on Welfare Capitalism Based on Taxing the Rich -- 4.12. Systems Thinking: New Ways of Understanding Free Enterprise Capitalist System -- 4.13. A Systems View for Resolving Capitalist Problems -- 4.14. New Ways of Understanding Capitalism -- 4.15. Inclusive Capitalism -- 4.16. Inclusive Capitalism and Intentional Public Policies -- 4.17. Conscious Capitalism -- 4.18. The Dharma of Capitalism -- 4.19. Concluding Remarks -- Chapter 5 The Destruction of Free Enterprise Capitalist System When Infected by Fraud, Corruption, and Bribery -- Executive Summary -- 5.1. Introduction. , 5.2. Corporate Fraud and Corporate Damages -- 5.3. Contemporary Versions of Fraud, Corruption, and Bribery -- 5.4. Investigating Fraud, Corruption, and Bribery -- 5.4.1 Seduction -- 5.5. Types of Corporate Fraud -- 5.6. Basic Instruments of Market Turbulence as Corporate Frauds -- 5.7. Market Turbulence of Capitalism as Boundary Thinking -- 5.8. The Inherent Social Contradictions of Capitalism -- 5.9. Other Social Externalities of Capitalism -- 5.10. What Can Turbulent Markets Do to Combat Fraud? -- 5.11. Fraud is Failure of Corporate Accountability -- 5.12. How Do We Combat Corporate Fraud? -- 5.13. Why Does Corporate Failure in Ethics Occur? -- 5.14. Reduce Fraud by Reducing Legal and Occupational Ambiguity -- 5.15. Concluding Remarks -- Notes -- Chapter 6 The Turbulent Market of Modern Debt-overleveraged and Promoter-dominated Corporations -- Executive Summary -- References -- References -- References -- 6.1. Ethics of Promoter Dominance in Modern Corporations -- 6.2. The Morality of Promoter Dominance -- 6.3. The Morality of Tax Subsidy and Debt Distortion -- 6.3.1. Advantages of Debt -- 6.3.2. Disadvantages of Debt -- 6.4. A New Breed of Hybrid Financial Instruments -- 6.5. Understanding Debt from Multiple Viewpoints -- 6.6. Ethics of Financing Decisions such as EBITDA -- 6.7. Bankruptcy and Credit -- 6.7.1. Bankruptcy assumes credit -- 6.8. Concluding Remarks -- 6.9. Ethical and Moral Concerns -- Notes -- Chapter 7 Artificial Intelligence and the Emergent Turbulent Markets: New Challenges to Corporate Ethics Today -- Executive Summary -- 7.1. Introduction -- 7.1.1. What Is AI? -- 7.1.2. The Fundamental Essence and Operations of AI -- 7.1.3. A Timeline of Major Advancements in AI -- 7.1.4. Current Wanton AI Developments -- 7.1.5. Advantages of AI -- 7.1.6. Disadvantages of AI -- 7.1.7. AI Will Not Automate All Jobs. , 7.1.8. The Great Potential of AI -- 7.2. The LEMS Challenge of AI to Corporate Ethics -- 7.2.1. Legal Aspects of AI -- 7.2.2. Ethical Challenges of AI -- 7.2.3. Moral Challenges of AI -- 7.2.4. Spiritual Challenges of AI -- 7.2.5. AI Contributes to Better Life -- 7.3. Concluding Remarks -- Notes -- Chapter 8 The Ethics of Reinventing the Morally Embattled Corporation -- Executive Summary -- 8.1. Introduction -- 8.2. Imperfections in the FECS-based Corporation -- 8.3. Growing Dissatisfaction with Corporations -- 8.4. Promoter Dominance Paralyzes the Corporation -- 8.5. Share Buyback for Restoring Corporate Control -- 8.6. High-potential Dynamic Startups -- 8.7. Crowd-funding and Crowd Innovations Challenge the Corporation -- 8.8. Is the Corporation an Over-taxed Endangered Species Today? -- 8.9. Chinese Economic Invasion Threatens American Capitalism and the Corporation -- 8.10. Reinventing the Capitalist Corporation -- 8.10.1. Reinventing the Corporation -- 8.10.1.1. Fluidity of Asset Management -- 8.10.1.2. Change in Ownership -- 8.10.1.3. Long-termism and NPDD -- 8.10.1.4. Comprehensive and Collaborative Entrepreneurship, Social Entrepreneurship, and Startups -- 8.10.1.5. Corporate Governance -- 8.10.1.6. Democratization of Capital -- 8.11. Concluding Challenge -- 8.12. Ethical Questions: -- Notes -- Epilogue: The Twenty-first Century Legal, Ethical, Moral, and Spiritual (LEMS) Challenges of Corporate Governance -- Executive Summary -- Corporate Value Ethics -- Organizational Morality as Systems Thinking -- Systems Thinking for Understanding Market Turbulence -- Capitalism and Economic Freedom -- Ethics of Free Enterprise Competition: The Golden Rule -- Market Turbulence and Market Disruption -- Concluding Remarks -- Notes -- References -- Further Reading -- Author Index -- Case Index -- Subject Index.

Additional Edition: ISBN 1-78756-190-9

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Language: English

Subjects: Economics

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Note: Intro -- Part I Core Concepts -- 1 What is a Cyber-Physical System? -- 1.1 Our Planet. Our Knowledge. Our Destiny -- 1.2 Observe. Understand. Innovate -- 1.2.1 Cyber-Physical Systems and Hybrid Systems -- 1.2.2 Examples -- 1.2.3 Computational vs. Physical Systems -- 1.2.4 Biological and Intelligent Systems -- 1.3 Developing New Products -- 1.4 Is the Field of Cyber-Physical Systems New? -- 1.5 What You Will Learn from This Book, and How -- 1.6 A Writing Tip -- 1.7 Chapter Highlights -- 1.8 Study Problems -- 1.9 Lab: Warm Up Exercises -- 1.10 Project -- 1.11 To Probe Further -- 2 Modeling Physical Systems -- 2.1 Reconnecting with the Physical World -- 2.2 Conservation Laws -- 2.3 Elements in Mechanical Systems -- 2.4 Working in 2D and 3D -- 2.5 Elements in Electrical Systems -- 2.6 The Absence or Presence of Time in a Model -- 2.7 Arithmetic Equations, and Linear and Non-linear Systems of Equations -- 2.8 Where Different Numbers Come from -- 2.9 Time-Dependent and Differential Equations -- 2.10 Prototypes of Equations (That Will Recur Throughout the Book) -- 2.11 Remarks on the Basic Machinery for Solving Differential Equations -- 2.12 Chapter Highlights -- 2.13 Study Problems -- 2.14 Lab: Spring Bouncing and Object Creation -- 2.15 Project: Mascot and Ping Pong Game -- 2.16 To Probe Further -- 3 Hybrid Systems -- 3.1 Introduction -- 3.2 Hybrid Automata -- 3.3 Reset Maps -- 3.4 Zero-Crossing -- 3.5 Zeno Behavior -- 3.6 Modeling Elastic Collision -- 3.7 Chapter Highlights -- 3.8 Avoid Common Mistakes -- 3.9 Study Problems -- 3.10 Lab: Discrete Bouncing -- 3.11 Project: Speed-Based Player for Ping Pong Robot -- 3.12 To Probe Further -- 4 Control Theory -- 4.1 Introduction -- 4.2 Feedback Control -- 4.3 Proportional Feedback Control -- 4.4 Operational Amplifiers -- 4.5 Multi-Dimensional Error and Proportional/Integral/Differential Feedback Control. , 4.6 Chapter Highlights -- 4.7 Study Problems -- 4.8 Lab: Exploring Control -- 4.9 Project: Acceleration-Based Player for Ping Pong Robot -- 4.10 To Probe Further -- 5 Modeling Computational Systems -- 5.1 Introduction -- 5.2 Quantization -- 5.3 Discretization: How Fast Can Your Circuit Go? -- 5.4 Detour: Boundedness of Digital Memory -- 5.5 Detour: From Hardware to Software-Storing Executable Commands in Memory -- 5.6 The Effect of Quantization and Discretization on Stability -- 5.7 Abstract Modeling of Computational Effects -- 5.8 Modeling Quantization -- 5.9 Modeling Discretization -- 5.10 Detour: Discretization, Sampling Rates, and Loss of Information -- 5.11 The Effects of Quantization and Discretization Easily Compound -- 5.12 Chapter Highlights -- 5.13 Study Problems -- 5.14 Lab: Stability Exercises -- 5.15 Project: Quantization and Discretization -- 5.16 To Probe Further -- 6 Coordinate Transformation (Robot Arm) -- 6.1 Introduction -- 6.2 Coordinate Transformation -- 6.3 Chapter Highlights -- 6.4 Study Problems -- 6.5 Lab: Coordinate Transformations -- 6.6 Project: Spherical-Actuation for Ping Pong Robot -- 6.7 To Probe Further -- Part II Selected Topics -- 7 Game Theory -- 7.1 The Role of Game Theory in CPS Design -- 7.2 Games, Players, Strategies, Utilities, and Independent Maximization -- 7.3 Rationality, Independence and Strictly Dominant (or Dominated) Strategies -- 7.3.1 The Independence Pattern -- 7.3.2 The Cost of Lacking Communication and Trust Can Be Unbounded -- 7.4 Coordination, Intelligence, and Nash Equilibrium -- 7.4.1 The Coordination Pattern -- 7.4.2 Nash Equilibrium -- 7.4.3 Determining the Nash Equilibrium -- 7.4.4 Eliminating Strictly Dominated Strategies Preserves Nash Equilibria -- 7.5 Competitiveness, Privacy, Mixed Strategies -- 7.5.1 Mixed Strategy Games. , 7.5.2 Selecting a Mixed Strategy (or, Mixed Strategy Nash Equilibria) -- 7.6 Chapter Highlights -- 7.7 Study Problems -- 7.8 To Probe Further -- 8 Communications -- 8.1 Communication, Certainty, Uncertainty, and Belief -- 8.2 Messages: From Information to Representation -- 8.3 Belief, Knowledge, and Truth -- 8.3.1 Broader Implications -- 8.4 Carrier Signal, Medium, and Link -- 8.5 Link Characteristics -- 8.5.1 Latency -- 8.5.2 Bandwidth -- 8.5.3 Reliability -- 8.6 Fundamental Limits from Physics -- 8.7 Limits Due to Component Dynamics -- 8.7.1 Electrical Signal Transmission -- 8.7.2 Variability in Component Parameters -- 8.7.3 Light and Radio Transmission -- 8.8 Limits Due to Noise -- 8.9 Limits Due to Energy Dissipation -- 8.10 Other Sources of Limitations -- 8.11 Chapter Highlights -- 8.12 Study Problems -- 8.13 To Probe Further -- 9 Sensing and Actuation -- 9.1 Everyday Input and Output -- 9.2 Symmetry: LEDs and Photo-Voltaic Cells -- 9.2.1 Diodes -- 9.2.2 The Photo-Voltaic Effect -- 9.2.3 Transistors and Amplifiers -- 9.3 Analog-to-Digital Conversion (ADC) -- 9.4 Digital-to-Analog Conversion (DAC) -- 9.5 Sensing Temperature -- 9.6 Sensing Position -- 9.7 Actuating Mechanical Systems -- 9.8 Chapter Highlights -- 9.9 Study Problems -- 9.10 To Probe Further -- A Acumen Reference Manual -- A.1 Background -- A.2 The Acumen Environment and Graphical User Interface -- A.3 Basic Structure of An Acumen Model -- A.4 Model Parameters and the ``Initially'' and ``Always'' Sections -- A.5 Model Instantiation -- A.6 Expressions -- A.6.1 Variable Names -- A.6.2 Literals -- A.6.3 Vector and Vector Generators -- A.6.4 Matrices -- A.6.5 Summations -- A.7 Formulae -- A.7.1 Continuous Formulae -- A.7.2 If Formulae -- A.7.3 Match Formulae -- A.7.4 Discrete Formulae -- A.7.5 Foreach Formulae -- A.7.6 Collections of Formulae. , A.8 How a Model Is Simulated: Order of Evaluation -- A.9 Visualization Using the _3D Panel -- A.9.1 Colors -- A.9.2 Transparency -- A.9.3 Coordinate System -- A.9.4 Text -- A.9.5 Box -- A.9.6 Cylinders -- A.9.7 Cone -- A.9.8 Spheres -- A.9.9 OBJ Mesh Objects -- A.9.10 Default Values -- A.9.11 Composites -- A.9.12 Shapes, Their Parameters, and Their Default Values -- A.9.13 Animation = Dynamic _3D Values -- A.9.14 Manual Control of the View of the _3D Scene -- A.9.15 In-model Control of the View of the _3D Scene -- A.9.16 Camera View -- A.10 Built-In Functions -- A.11 Function Declarations -- A.12 Operator Precedence -- A.13 Simulator Settings -- A.14 Command Line Parameters -- A.15 Print to Standard Output (stdout) or Console -- A.16 BNF of Acumen -- Index.

Additional Edition: Print version: Taha, Walid M. Cyber-Physical Systems: a Model-Based Approach Cham : Springer International Publishing AG,c2020 ISBN 9783030360702

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Content: This book provides an introduction to the mathematical and algorithmic foundations of data science, including machine learning, high-dimensional geometry, and analysis of large networks. Topics include the counterintuitive nature of data in high dimensions, important linear algebraic techniques such as singular value decomposition, the theory of random walks and Markov chains, the fundamentals of and important algorithms for machine learning, algorithms and analysis for clustering, probabilistic models for large networks, representation learning including topic modelling and non-negative matrix factorization, wavelets and compressed sensing. Important probabilistic techniques are developed including the law of large numbers, tail inequalities, analysis of random projections, generalization guarantees in machine learning, and moment methods for analysis of phase transitions in large random graphs. Additionally, important structural and complexity measures are discussed such as matrix norms and VC-dimension. This book is suitable for both undergraduate and graduate courses in the design and analysis of algorithms for data.

Note: Title from publisher's bibliographic system (viewed on 29 Jan 2020). , Cover -- Half-title -- Title page -- Copyright information -- Contents -- 1 Introduction -- 2 High-Dimensional Space -- 2.1 Introduction -- 2.2 The Law of Large Numbers -- 2.3 The Geometry of High Dimensions -- 2.4 Properties of the Unit Ball -- 2.4.1 Volume of the Unit Ball -- 2.4.2 Volume near the Equator -- 2.5 Generating Points Uniformly at Random from a Ball -- 2.6 Gaussians in High Dimension -- 2.7 Random Projection and Johnson-Lindenstrauss Lemma -- 2.8 Separating Gaussians -- 2.9 Fitting a Spherical Gaussian to Data -- 2.10 Bibliographic Notes -- 2.11 Exercises -- 3 Best-Fit Subspaces and Singular Value Decomposition (SVD) -- 3.1 Introduction -- 3.2 Preliminaries -- 3.3 Singular Vectors -- 3.4 Singular Value Decomposition (SVD) -- 3.5 Best Rank-k Approximations -- 3.6 Left Singular Vectors -- 3.7 Power Method for Singular Value Decomposition -- 3.7.1 A Faster Method -- 3.8 Singular Vectors and Eigenvectors -- 3.9 Applications of Singular Value Decomposition -- 3.9.1 Centering Data -- 3.9.2 Principal Component Analysis -- 3.9.3 Clustering a Mixture of Spherical Gaussians -- 3.9.4 Ranking Documents and Web Pages -- 3.9.5 An Illustrative Application of SVD -- 3.9.6 An Application of SVD to a Discrete Optimization Problem -- 3.10 Bibliographic Notes -- 3.11 Exercises -- 4 Random Walks and Markov Chains -- 4.1 Stationary Distribution -- 4.2 Markov Chain Monte Carlo -- 4.2.1 Metropolis-Hasting Algorithm -- 4.2.2 Gibbs Sampling -- 4.3 Areas and Volumes -- 4.4 Convergence of Random Walks on Undirected Graphs -- 4.4.1 Using Normalized Conductance to Prove Convergence -- 4.5 Electrical Networks and Random Walks -- 4.6 Random Walks on Undirected Graphs with Unit Edge Weights -- 4.6.1 Hitting Time -- 4.6.2 Commute Time -- 4.6.3 Cover Time -- 4.7 Random Walks in Euclidean Space -- 4.7.1 Random Walks on Lattices -- 4.7.2 Two Dimensions. , 4.7.3 Three Dimensions -- 4.8 The Web as a Markov Chain -- 4.8.1 Pagerank -- 4.8.2 Relation to Hitting Time -- 4.8.3 Spam -- 4.8.4 Personalized Pagerank -- 4.8.5 Algorithm for Computing Personalized Pagerank -- 4.9 Bibliographic Notes -- 4.10 Exercises -- 5 Machine Learning -- 5.1 Introduction -- 5.1.1 The Core Problem -- 5.1.2 How to Learn -- 5.2 The Perceptron Algorithm -- 5.3 Kernel Functions and Nonlinearly Separable Data -- 5.4 Generalizing to New Data -- 5.4.1 Overfitting and Uniform Convergence -- 5.4.2 Occam's Razor -- 5.4.3 Regularization: Penalizing Complexity -- 5.5 VC-Dimension -- 5.5.1 Definitions and Key Theorems -- 5.5.2 VC-Dimension of Some Set Systems -- 5.5.3 Shatter Function for Set Systems of Bounded VC-Dimension -- 5.5.4 VC-Dimension of Combinations of Concepts -- 5.5.5 The Key Theorem -- 5.6 VC-Dimension and Machine Learning -- 5.7 Other Measures of Complexity -- 5.8 Deep Learning -- 5.8.1 Generative Adversarial Networks (GANs) -- 5.9 Gradient Descent -- 5.9.1 Stochastic Gradient Descent -- 5.9.2 Regularizer -- 5.10 Online Learning -- 5.10.1 An Example: Learning Disjunctions -- 5.10.2 The Halving Algorithm -- 5.10.3 The Perceptron Algorithm -- 5.10.4 Inseparable Data and Hinge Loss -- 5.10.5 Online to Batch Conversion -- 5.10.6 Combining (Sleeping) Expert Advice -- 5.11 Boosting -- 5.12 Further Current Directions -- 5.12.1 Semi-Supervised Learning -- 5.12.2 Active Learning -- 5.12.3 Multitask Learning -- 5.13 Bibliographic Notes -- 5.14 Exercises -- 6 Algorithms for Massive Data Problems: Streaming, Sketching, and Sampling -- 6.1 Introduction -- 6.2 Frequency Moments of Data Streams -- 6.2.1 Number of Distinct Elements in a Data Stream -- 6.2.2 Number of Occurrences of a Given Element -- 6.2.3 Frequent Elements -- 6.2.4 The Second Moment -- 6.3 Matrix Algorithms Using Sampling -- 6.3.1 Matrix Multiplication Using Sampling. , 6.3.2 Implementing Length Squared Sampling in Two Passes -- 6.3.3 Sketch of a Large Matrix -- 6.4 Sketches of Documents -- 6.5 Bibliographic Notes -- 6.6 Exercises -- 7 Clustering -- 7.1 Introduction -- 7.1.1 Preliminaries -- 7.1.2 Two General Assumptions on the Form of Clusters -- 7.1.3 Spectral Clustering -- 7.2 k-Means Clustering -- 7.2.1 A Maximum-Likelihood Motivation -- 7.2.2 Structural Properties of the k-Means Objective -- 7.2.3 Lloyd's Algorithm -- 7.2.4 Ward's Algorithm -- 7.2.5 k-Means Clustering on the Line -- 7.3 k-Center Clustering -- 7.4 Finding Low-Error Clusterings -- 7.5 Spectral Clustering -- 7.5.1 Why Project? -- 7.5.2 The Algorithm -- 7.5.3 Means Separated by Ω(1) Standard Deviations -- 7.5.4 Laplacians -- 7.5.5 Local Spectral Clustering -- 7.6 Approximation Stability -- 7.6.1 The Conceptual Idea -- 7.6.2 Making This Formal -- 7.6.3 Algorithm and Analysis -- 7.7 High-Density Clusters -- 7.7.1 Single Linkage -- 7.7.2 Robust Linkage -- 7.8 Kernel Methods -- 7.9 Recursive Clustering Based on Sparse Cuts -- 7.10 Dense Submatrices and Communities -- 7.11 Community Finding and Graph Partitioning -- 7.12 Spectral Clustering Applied to Social Networks -- 7.13 Bibliographic Notes -- 7.14 Exercises -- 8 Random Graphs -- 8.1 The G(n,p) Model -- 8.1.1 Degree Distribution -- 8.1.2 Existence of Triangles in G(n, d/n) -- 8.2 Phase Transitions -- 8.3 Giant Component -- 8.3.1 Existence of a Giant Component -- 8.3.2 No Other Large Components -- 8.3.3 The Case of p < -- 1/n -- 8.4 Cycles and Full Connectivity -- 8.4.1 Emergence of Cycles -- 8.4.2 Full Connectivity -- 8.4.3 Threshold for O(ln n) Diameter -- 8.5 Phase Transitions for Increasing Properties -- 8.6 Branching Processes -- 8.7 CNF-SAT -- 8.7.1 SAT-Solvers in Practice -- 8.7.2 Phase Transitions for CNF-SAT -- 8.8 Nonuniform Models of Random Graphs. , 8.8.1 Giant Component in Graphs with Given Degree Distribution -- 8.9 Growth Models -- 8.9.1 Growth Model without Preferential Attachment -- 8.9.2 Growth Model with Preferential Attachment -- 8.10 Small-World Graphs -- 8.11 Bibliographic Notes -- 8.12 Exercises -- 9 Topic Models, Nonnegative Matrix Factorization, Hidden Markov Models, and Graphical Models -- 9.1 Topic Models -- 9.2 An Idealized Model -- 9.3 Nonnegative Matrix Factorization -- 9.4 NMF with Anchor Terms -- 9.5 Hard and Soft Clustering -- 9.6 The Latent Dirichlet Allocation Model for Topic Modeling -- 9.7 The Dominant Admixture Model -- 9.8 Formal Assumptions -- 9.9 Finding the Term-Topic Matrix -- 9.10 Hidden Markov Models -- 9.11 Graphical Models and Belief Propagation -- 9.12 Bayesian or Belief Networks -- 9.13 Markov Random Fields -- 9.14 Factor Graphs -- 9.15 Tree Algorithms -- 9.16 Message Passing in General Graphs -- 9.16.1 Graphs with a Single Cycle -- 9.16.2 Belief Update in Networks with a Single Loop -- 9.16.3 Maximum Weight Matching -- 9.17 Warning Propagation -- 9.18 Correlation between Variables -- 9.19 Bibliographic Notes -- 9.20 Exercises -- 10 Other Topics -- 10.1 Ranking and Social Choice -- 10.1.1 Randomization -- 10.1.2 Examples -- 10.2 Compressed Sensing and Sparse Vectors -- 10.2.1 Unique Reconstruction of a Sparse Vector -- 10.2.2 Efficiently Finding the Unique Sparse Solution -- 10.3 Applications -- 10.3.1 Biological -- 10.3.2 Low-Rank Matrices -- 10.4 An Uncertainty Principle -- 10.4.1 Sparse Vector in Some Coordinate Basis -- 10.4.2 A Representation Cannot Be Sparse in Both Time and Frequency Domains -- 10.5 Gradient -- 10.6 Linear Programming -- 10.6.1 The Ellipsoid Algorithm -- 10.7 Integer Optimization -- 10.8 Semi-Definite Programming -- 10.9 Bibliographic Notes -- 10.10 Exercises -- 11 Wavelets -- 11.1 Dilation -- 11.2 The Haar Wavelet. , 11.3 Wavelet Systems -- 11.4 Solving the Dilation Equation -- 11.5 Conditions on the Dilation Equation -- 11.6 Derivation of the Wavelets from the Scaling Function -- 11.7 Sufficient Conditions for the Wavelets to Be Orthogonal -- 11.8 Expressing a Function in Terms of Wavelets -- 11.9 Designing a Wavelet System -- 11.10 Applications -- 11.11 Bibliographic Notes -- 11.12 Exercises -- 12 Background Material -- 12.1 Definitions and Notation -- 12.1.1 Integers -- 12.1.2 Substructures -- 12.1.3 Asymptotic Notation -- 12.2 Useful Relations -- 12.3 Useful Inequalities -- 12.4 Probability -- 12.4.1 Sample Space, Events, and Independence -- 12.4.2 Linearity of Expectation -- 12.4.3 Union Bound -- 12.4.4 Indicator Variables -- 12.4.5 Variance -- 12.4.6 Variance of the Sum of Independent Random Variables -- 12.4.7 Median -- 12.4.8 The Central Limit Theorem -- 12.4.9 Probability Distributions -- 12.4.10 Bayes Rule and Estimators -- 12.5 Bounds on Tail Probability -- 12.5.1 Chernoff Bounds -- 12.5.2 More General Tail Bounds -- 12.6 Applications of the Tail Bound -- 12.7 Eigenvalues and Eigenvectors -- 12.7.1 Symmetric Matrices -- 12.7.2 Relationship between SVD and Eigen Decomposition -- 12.7.3 Extremal Properties of Eigenvalues -- 12.7.4 Eigenvalues of the Sum of Two Symmetric Matrices -- 12.7.5 Norms -- 12.7.6 Important Norms and Their Properties -- 12.7.7 Additional Linear Algebra -- 12.7.8 Distance between Subspaces -- 12.7.9 Positive Semi-Definite Matrix -- 12.8 Generating Functions -- 12.8.1 Generating Functions for Sequences Defined by Recurrence Relationships -- 12.8.2 The Exponential Generating Function and the Moment Generating Function -- 12.9 Miscellaneous -- 12.9.1 Lagrange Multipliers -- 12.9.2 Finite Fields -- 12.9.3 Application of Mean Value Theorem -- 12.10 Exercises -- References -- Index.

Additional Edition: Online version: Blum, Avrim, 1966- Foundations of data science New York, NY : Cambridge University Press, 2020. ISBN 9781108755528

Additional Edition: ISBN 9781108485067

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ISBN: 0-323-97219-5 , 9780323972192 , 0323972195

Content: "Advanced and Modern Approaches for Drug Delivery explores novel approaches currently used for drug delivery, including the must up-to-date techniques and technology. The approaches discussed allow pharmaceutical scientists to design effective drug delivery systems or devices for the management and treatment of numerous diseases and conditions. Detailed information on a wide variety of subjects, including dendrimers, lipid nanostructures, solid lipid nanoparticles, stimuli-responsive smart systems, self-assembled protein-drug nanoparticles, nanoconjugate formulations, nanofibers, iontophoretic systems, microneedle systems, ultra-sound triggered systems, targeted carrier-based intracellular delivery systems, resealed erythrocyte-based systems, 3 D-printing tool, site-specific monoclonal antibodies, and bio-inspired systems are all comprehensively discussed." --Provided by publisher

Note: Front Cover -- Advanced and Modern Approaches for Drug Delivery -- Advanced and Modern Approaches for Drug Delivery -- Copyright -- Contents -- Contributors -- 1 - Novel drug delivery system -- 1. Introduction -- 1.1 Advantages of NDDS -- 2. Novel drug delivery system -- 2.1 Liposomes -- 2.1.1 Composition of liposomes -- 2.1.2 Classification of liposomes -- 2.1.3 Advance and a recent update on the liposomes -- 2.1.3.1 Conventional liposomes comprising a phospholipid -- 2.1.3.2 PEGylated/stealth liposomes -- 2.1.3.3 Ligand-targeted liposomes -- 2.1.3.4 Multifunctional liposomes -- 2.1.4 Liposomes-based marketed products -- 2.2 Transfersomes -- 2.2.1 Merit/demerit of transferesomes -- 2.3 Ethosomes -- 2.3.1 Advantages of ethosomes -- 2.4 Nanoparticles -- 2.4.1 Advantages of nanoparticles -- 2.5 Microspheres -- 2.5.1 Advantages of microspheres -- 2.6 Phytosomes -- 2.6.1 Advantages of phytosomes -- 2.7 Solid lipid nanoparticles -- 2.7.1 Advantage of SLNs -- 2.8 Niosomes -- 2.8.1 Advantages of niosomes -- 2.9 Proniosomes -- 2.9.1 Advantages of proniosomes -- 2.10 Liquid crystals -- 2.10.1 Advantages of liquid crystals -- 2.11 Dendrimer -- 2.11.1 Advantages of dendrimers -- 2.12 Hydrogels -- 2.12.1 Advantages of hydrogels -- 3. Conclusion -- References -- Further reading -- 2 - Self-emulsifying systems for drug delivery: advances and challenges -- 1. Introduction -- 2. Construction of pseudoternary phase diagrams -- 3. Self-emulsifying systems for oral drug delivery -- 3.1 General components of SEDDSs for oral drug delivery -- 3.2 Applications of SEDDSs for oral drug delivery -- 3.2.1 Liquid SEDDSs for oral drug delivery -- 3.2.2 Solid SEDDSs (S-SEDDSs) for oral drug delivery -- 3.2.3 Supersaturable SEDDSs for oral drug delivery -- 4. Self-emulsifying ocular drug delivery systems -- 5. Self-emulsifying dermal and transdermal drug delivery systems. , 5.1 Transdermal drug delivery -- 5.2 Targeted delivery to skin strata -- 6. Self-emulsifying vaginal drug delivery systems -- 7. Self-emulsifying rectal drug delivery systems -- 8. Self-emulsifying parenteral drug delivery systems -- 9. Concluding remarks -- References -- 3 - Gastroretentive drug delivery approaches: concepts, approaches, and applications -- 1. Introduction -- 2. Gastroretentive drug delivery systems -- 3. Anatomy and physiology of the stomach -- 4. Factors affecting gastric retention ability of a delivery system -- 5. Approaches to developing GRDDS -- 5.1 Mucoadhesive systems -- 5.2 High-density systems -- 5.3 Floating systems -- 6. Swellable and expandable systems -- 7. Magnetic systems -- 8. Application of gastroretentive dosage forms -- 9. Conclusion -- References -- 4 - Current advancements in nasopulmonary drug delivery systems -- 1. Introduction -- 2. Anatomy and physiology of the respiratory system -- 3. Advantages and limitations of the nasopulmonary route -- 3.1 Mucociliary clearance -- 3.2 Alveolar macrophages -- 3.3 Enzymatic degradation -- 3.4 Rapid systemic absorption -- 4. Factors determining pulmonary drug distribution, effectiveness, and clearance -- 4.1 Particle size -- 4.2 Particle shape -- 4.3 Stealth ability -- 5. Materials selection for NPDDSSs -- 6. Applications of NPDDSs -- 7. Methods of targeting in NPDDSs -- 8. Next-generation impactor devices as lung simulators -- Acknowledgement -- References -- 5 - Osmotic drug deliverance systems: concepts, approaches, and applications -- 1. Introduction -- 2. Controlled drug deliverance by osmosis machineries -- 3. Concept of osmosis -- 4. Basic ingredients of osmotic machineries -- 4.1 Medication -- 4.2 Osmotic agent -- 4.3 Semipenetrable membrane -- 4.4 Substance for semipenetrable membrane -- 4.4.1 Cellulose acetate membrane -- 4.4.2 Compound polyamide membrane. , 4.4.3 Arbitrary feature of semipenetrable membrane -- 4.5 Hole forming factors -- 4.6 Covering solvent -- 4.7 Emulsifying agents -- 4.8 Flux moderating factors -- 4.9 Wicking factors -- 4.10 Barrier cortex formers -- 4.11 Plasticizers -- 5. Sorts of osmotically controlled drug deliverance devices -- 5.1 Oral osmotic drug deliverance devices -- 5.1.1 Single chamber osmotic pump -- 5.1.1.1 Elementary osmotic pump (EOP) -- 5.1.1.2 Controlled porosity of osmotic pump (COP) -- 5.1.1.3 Osmotic erupting osmotic pump -- 5.1.2 Multichamber osmotic pump -- 5.1.2.1 Push-pull osmotic pump -- 5.1.2.2 Osmotic pump with nonextending secondary section -- 5.1.2.3 Sandwich osmotic tablets (SOTS) -- 5.2 Implantable osmotic drug deliverance devices -- 5.2.1 Rose and nelson pump -- 5.2.2 Higuchi leeper pump -- 5.2.3 Higuchi theeuwes pump -- 5.2.4 Oral osmotic capsules -- 5.2.4.1 OROS-CT -- 5.2.4.2 Liquid oral release osmotic system (L-OROS) -- 5.2.4.3 Multiparticulate delayed release systems -- 5.2.4.4 Telescopic capsule for postponed diffusion -- 6. Conclusion -- References -- 6 - Nanogels as drug delivery platform -- 1. Introduction -- 2. Bibliometric analysis of the nanogels as drug delivery platform -- 3. Drug release -- 4. Nanogels as a drug delivery platform in different systems -- 5. Other applications -- 6. Global market report -- 7. Disadvantages of the use of nanogels as drug carriers -- 8. Conclusions -- References -- 7 - Nanoliposomes as safe and efficient drug delivery nanovesicles -- 1. Introduction -- 2. Nanoliposomes preparation -- 2.1 Chemical components -- 2.2 Methods of preparation -- 2.2.1 Thin-layer hydration -- 2.2.2 Reverse-phase evaporation -- 2.2.3 Solvent injection -- 2.2.4 Heating method -- 2.2.5 Freeze-drying method -- 2.2.6 Microfluidics channel -- 2.2.7 Supercritical fluids -- 3. Methods of drug loading -- 3.1 Passive loading techniques. , 3.2 Active loading techniques -- 3.2.1 pH gradient -- 3.2.2 Ammonium sulfate gradient -- 3.2.3 Metal-ion complexation gradient -- 4. Analysis and characterization of nanoliposomes -- 4.1 Particle size and morphology -- 4.2 Surface charge -- 4.3 Zeta potential -- 4.4 Polydispersity index -- 4.5 Encapsulation efficiency and loading capacity -- 4.6 Drug release -- 5. Types of nanoliposomes in drug delivery -- 5.1 Conventional nanoliposomes -- 5.2 PEGylated nanoliposomes -- 5.3 Coated nanoliposomes -- 5.4 Targeted nanoliposomes -- 5.5 Stimulus-responsive nanoliposomes -- 6. Stability and safety of nanoliposomes -- 7. Applications of nanoliposomes in treatment of human diseases -- 7.1 Treatment of cancer -- 7.1.1 Passive delivery -- 7.1.2 Targeted delivery -- 7.1.3 Stimulus responsive delivery -- 7.2 Treatment of neurological disorders -- 7.3 Treatment of liver diseases -- 8. Nanoliposomal vaccines -- 9. Nanoliposomal bioreactors -- 10. Nanoliposomes in theranostics -- 11. Marketed nanoliposomes and future challenges -- 12. Conclusions -- References -- 8 - Transferosomes: a novel nanotechnological approach for transdermal drug delivery -- 1. Introduction -- 2. Transferosomes -- 3. Advantages of transferosomes -- 4. Limitations of transferosomes -- 5. Composition of transferosomes -- 6. Mechanism of penetration of transferosomes across stratum corneum -- 7. Methods of transferosome preparation -- 7.1 Vortexing-sonication -- 7.2 Rotary film evaporation -- 7.3 Reverse-phase evaporation -- 7.4 Freeze-thaw method -- 7.5 Ethanol injection -- 7.6 Homogenization/extrusion -- 7.7 Protransferosome-transferosome method -- 7.8 Microfluidics method -- 8. Characterizations of transferosomes -- 8.1 Vesicle size and distribution -- 8.2 Zeta-potential -- 8.3 Drug entrapment efficiency -- 8.4 Surface topography -- 8.5 Number of vesicles per cubic mm -- 8.6 Drug content. , 8.7 Turbidity measurement -- 8.8 Measurement of degree of deformability or permeability -- 8.9 Penetration ability -- 8.10 Occlusion effects -- 8.11 Confocal scanning laser microscopy (CSLM) study -- 8.12 In vitro drug release evaluation -- 8.13 In vitro skin permeation study -- 9. Applications of transferosomes -- 9.1 Protein and peptide delivery -- 9.2 Corticosteroids -- 9.3 Anticancer drugs -- 9.4 Anaesthetics -- 9.5 Nonsteroidal anti-inflammatory drugs (NSAIDs) -- 9.6 Antipsycotic drugs -- 10. Conclusions -- References -- 9 - Niosomes as a promising nanovesicular drug delivery -- 1. Introduction -- 2. Composition of niosomes -- 2.1 Nonionic surfactants -- 2.2 Cholesterol -- 2.3 Charge inducer molecules -- 2.4 Hydration medium -- 3. Factors affecting niosomal formulation -- 3.1 Surfactant -- 3.2 Cholesterol -- 3.3 Drug -- 3.4 Hydration condition -- 3.5 Resistance to osmotic stress -- 3.6 Method of preparation -- 4. Types of niosomes -- 5. Fabrication methods of niosomes -- 5.1 Thin layer evaporation/handshaking -- 5.2 Reverse phase evaporation -- 5.3 Bubble -- 5.4 Ether injection -- 5.5 Sonication -- 5.6 Microfluidization -- 5.7 Transmembrane pH gradient -- 5.8 Membrane extrusion -- 5.9 Single pass -- 5.10 Handjani-vila -- 5.11 Heating -- 5.12 Freeze and thaw -- 5.13 Enzymatic -- 5.14 Microfluidic hydrodynamic focusing -- 5.15 Dehydration-rehydration -- 5.16 Supercritical carbon dioxide fluid (scCO2) -- 5.17 Lipid injection -- 5.18 Emulsion -- 5.19 Formation of niosomes from proniosomes -- 6. Methods for controlling the size of niosomes -- 6.1 Fractionation -- 6.2 Homogenization -- 6.3 Extrusion -- 7. Niosome purification -- 7.1 Dialysis -- 7.2 Reverse dialysis -- 7.3 Gel filtration/column chromatography -- 7.4 Centrifugation -- 7.5 Ultra-centrifugation -- 8. Characterization of niosomes -- 8.1 Size, morphology, and size distribution. , 8.2 Vesicular surface charge and zeta potential.

Additional Edition: Print version: Nayak, Amit Kumar Advanced and Modern Approaches for Drug Delivery San Diego : Elsevier Science & Technology,c2023 ISBN 9780323916684

Language: English

UID:

Format: 1 online resource (379 pages)

ISBN: 9780443186172

Series Statement: Heterocyclic Drug Discovery

Content: Fused Pyrimidine-Based Drug Discovery covers all categories of fused-pyrimidines along with pharmacological and in silico studies. It covers the chemistry and biological activities, as well as the design of novel fused-pyrimidine scaffolds. N-Heterocyclic scaffolds are found in most known drug candidates, and are of interest to medicinal and organic chemists to design, synthesize and evaluate their biological properties. A variety of fused-pyrimidine molecules have been synthesized and extracted from natural resources, and are found to exhibit various biological activities such as antifolates, anticancer agents, analgesics, antimetabolites, CNS active agents and many more. Some of these scaffolds like purines are also known to have involvement in biological processes and are part of the framework of genetic material. This book focuses on the classification, structural chemistry, and chemical and physical properties along with various approaches for their synthesis.

Note: Front Cover -- Fused Pyrimidine-Based Drug Discovery -- Fused Pyrimidine-Based Drug Discovery Heterocyclic Drug Discovery -- Copyright -- Contents -- Contributors -- Biographies -- Foreword -- Foreword -- Foreword -- Acknowledgments -- 1 - Introduction -- 1.1 Introduction -- References -- 2 - FDA approved fused pyrimidine-based drugs -- 2.1 Introduction -- 2.2 Fused pyrimidine-based anticancer drugs -- 2.3 Fused pyrimidine-based drugs as anti-viral agents -- 2.4 Fused pyrimidine-based drugs for cardiovascular disorders -- 2.5 Fused pyrimidine-based drugs for respiratory disorders -- 2.6 Fused pyrimidine-based drugs for inflammatory diseases -- 2.7 Fused pyrimidine-based drugs for neurological disorders -- 2.8 Fused pyrimidine-based drugs for treatment of benign prostatic hypertrophy (BPH) -- 2.9 Fused pyrimidine-based drugs for treatment of erectile dysfunction -- 2.10 Fused pyrimidine-based drugs for miscellaneous use -- 2.11 Analysis of the approved drugs -- References -- 3 - Naturally occurring fused pyrimidine derivatives and their medicinal attributes -- 3.1 Introduction -- 3.1.1 Fused pyrimidine from plants -- 3.1.2 Fused pyrimidine derivatives from fungi -- 3.1.3 Fused pyrimidine derivatives obtained from sponges -- References -- 4 - Five-membered ring fused pyrimidine-based derivatives and their biological properties -- 4.1 Introduction -- 4.2 Pyrazolo[3,4-d]pyrimidine -- 4.2.1 Anticancer activity -- 4.2.2 α-amylase and α-glucosidase inhibitors -- 4.2.3 Anti-inflammatory activity -- 4.2.4 Antibacterial activity -- 4.3 Pyrrolo[1,2-c]pyrimidines, pyrrolo[2,3-d]pyrimidines and pyrrolo[3,2-d]pyrimidines -- 4.3.1 PI3Kα inhibitors -- 4.3.2 Antitumor agents -- 4.4 Thieno[2,3-d]pyrimidines and thieno[3,2-d]pyrimidines -- 4.4.1 DNase I inhibition activity -- 4.4.2 Anti-proliferative activity -- 4.5 Furo[3,2-d]pyrimidines and related heterocycles. , 4.5.1 G-protein coupled receptor (GPCR)119 agonists -- 4.5.2 Anti-cancer agents -- 4.5.3 Anti-HCV activity -- 4.5.4 Epidermal growth factor receptor (EGFR) inhibitors -- 4.6 Triazolo[1,5-a]pyrimidines, pyrazolo[1,5-a]pyrimidines, and pyrimido[1,2-a]benzimidazoles -- 4.6.1 Anti-cancer activity -- 4.6.2 Antitubercular activity -- 4.7 Pyrazolothienopyrimidine -- 4.8 Thiazolo[3,2-a]pyrimidines -- 4.8.1 Antimicrobial activity -- 4.8.2 Anticancer activity -- 4.8.3 Anti-inflammatory agents -- 4.8.4 Antibacterial and antitubercular agents -- 4.9 Thiazolo[4,5-d]pyrimidines -- 4.9.1 Cyclooxygenase inhibitors -- 4.10 Pyrido[4',3':4,5]thieno[2,3-d]pyrimidines -- 4.11 Recent patents -- Acknowledgments -- References -- 5 - FDA approved five-membered ring fused pyrimidine-based derivatives and their biological properties -- 5.1 Sildenafil -- 5.2 Valganciclovir -- 5.3 Duvelisib -- 5.4 Vidarabine -- 5.5 Abacavir -- 5.6 Entecavir -- 5.7 Ganciclovir -- 5.8 Acyclovir -- 5.9 Theophylline -- 5.10 Pemetrexed -- 5.11 Zanubrutinib -- 5.12 Cangrelor -- 5.13 Ticagrelor -- 5.14 Fludarabine -- 5.15 Valaciclovir -- 5.16 Nelarabine -- 5.17 Cladribine -- 5.18 Istradefylline -- 5.19 Penciclovir -- 5.20 Tofacitinib -- 5.21 Ribociclib -- 5.22 Tenofovir alafenamide -- 5.23 Ibrutinib -- 5.24 Udenafil -- 5.25 Allopurinol -- 5.26 Ruxolitinib -- 5.27 Baricitinib -- 5.28 Zaleplon -- 5.29 Azathioprine -- 5.30 Thioguanine -- 5.31 Anagliptin -- 5.32 Regadenoson -- 5.33 Adefovir dipivoxil -- 5.34 Clofarabine -- 5.35 Idelalisib -- 5.36 Didanosine -- 5.37 Famciclovir -- 5.38 Dyphylline -- 5.39 Pentoxifylline -- 5.40 Caffeine -- 5.41 Enprofylline -- References -- 6 - Benzene fused pyrimidine-based derivatives and their biological properties -- 6.1 Preface -- 6.2 Zorifertinib (AZD3759) -- 6.3 CZh226 -- 6.4 2-amino-4-methylquinazoline derivatives. , 6.5 (S)-3-((2-amino-8-fluoroquinazolin-4-yl)amino)hexan-1-ol -- 6.6 7-methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one -- 6.7 BMS-919373 -- 6.8 1-(4-((3-Chlorophenyl)amino)quinazolin-6-yl)-3-(3,5- difluorophenyl)thiourea -- 6.9 N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)- phenyl)-2-(pyridin-4-yl)quinazolin-4-amine -- 6.10 GSK2983559 -- References -- 7 - Six-membered ring (with N, O or S) fused pyrimidine-based derivatives and biological properties -- 7.1 Introduction -- 7.2 Classification -- 7.2.1 Nitrogen-containing six-membered rings fused with pyrimidine -- 7.2.1.1 Pyrido-pyrimidines -- 7.2.1.1.1 Pyrido[3,4-d]pyrimidines -- 7.2.1.1.2 Pyrido[2,3-d]pyrimidines -- 7.2.1.1.3 Pyrido[3,2-d]pyrimidines -- 7.2.1.1.4 Pyrido[4,3-d] pyrimidines -- 7.2.1.2 Pyrimidopyrimidines -- 7.2.1.2.1 Pyrimidio[1,6-a] and [1,6-c]pyrimidines -- 7.2.1.2.2 Pyrimido[4,5-d]pyrimidines -- 7.2.1.2.3 Pyrimido[5,4-d]Pyrimidines -- 7.2.1.2.4 Pyrimido[1,2-a]pyrimidines -- 7.2.1.3 Pteridine -- 7.2.2 Oxygen-containing six-membered ring fused with pyrimidine -- 7.2.2.1 Chromeno[2,3-d]pyrimidines -- 7.2.2.2 Pyrano[3,2-d]pyrimidines -- 7.2.2.3 Pyrano[2,3-d]pyrimidines -- 7.2.3 Sulphur containing six-membered rings fused with a pyrimidine -- 7.2.3.1 Thiopyrano[3,2-d]pyrimidines -- References -- 8 - FDA approved six-membered ring fused pyrimidine-based derivatives -- 8.1 Methotrexate -- 8.2 Risperidone -- 8.3 Pemirolast -- 8.4 Pralatrexate -- 8.5 Trametinib -- 8.6 Triamterene -- 8.7 Palbociclib -- 8.8 Dipyridamole -- 8.9 Prazosin -- 8.10 Alfuzosin -- 8.11 Trimetrexate -- 8.12 Anagrelide -- 8.13 Quinethazone -- 8.14 Copanlisib -- 8.15 Terazosin -- 8.16 Doxazosin -- 8.17 Gefitinib -- 8.18 Erlotinib -- 8.19 Afatinib -- 8.20 Dacomitinib -- 8.21 Vandetanib -- 8.22 Lapatinib -- 8.23 Idelalisib -- 8.24 Raltitrexed -- 8.25 Asasantin -- References. , 9 - Seven-membered ring fused pyrimidine-based derivatives and their biological properties -- 9.1 Introduction -- 9.2 Pyrimidine fused with a seven-membered ring containing nitrogen -- 9.3 Pyrimidine fused with a seven-membered ring containing oxygen -- 9.4 Pyrimidine fused with a seven-membered ring containing nitrogen and oxygen -- 9.5 Pyrimidine fused with a seven-membered ring containing sulphur -- 9.6 Pyrimidine fused with a seven-membered ring containing nitrogen and sulfur -- References -- 10 - Eight-membered fused pyrimidine derivatives and their biological properties -- 10.1 Introduction -- 10.2 Exploring the reported literature on eight-membered heterocycles fused with a pyrimidine ring -- 10.3 Tricyclic pyrimidine-fused eight-membered diazocines -- 10.3.1 Eight-membered rings (azocine) -- 10.4 Conclusion -- References -- 11 - Molecular modeling studies of fused pyrimidine derivatives at various receptors -- 11.1 Abacavir -- 11.1.1 Mechanism of action -- 11.1.2 Binding mode analysis -- 11.2 Acyclovir -- 11.2.1 Mechanism of action -- 11.2.2 Binding mode analysis -- 11.3 Adefovir dipivoxil -- 11.3.1 Mechanism of action -- 11.3.2 Binding mode analysis -- 11.4 Allopurinol -- 11.4.1 Mechanism of action -- 11.4.2 Binding mode analysis -- 11.5 Anagliptin -- 11.5.1 Mechanism of action -- 11.5.2 Binding mode analysis -- 11.6 Azathioprine -- 11.6.1 Mechanism of action -- 11.6.2 Binding mode analysis -- 11.7 Baricitinib -- 11.7.1 Mechanism of action -- 11.7.2 Binding mode analysis -- 11.8 Caffeine -- 11.8.1 Mechanism of action -- 11.8.2 Binding mode analysis -- 11.9 Cangrelor -- 11.9.1 Mechanism of action -- 11.9.2 Binding mode analysis -- 11.10 Cladribine -- 11.10.1 Mechanism of action -- 11.10.2 Binding mode analysis -- 11.11 Clofarabine -- 11.11.1 Mechanism of action -- 11.11.2 Binding mode analysis -- 11.12 Didanosine. , 11.12.1 Mechanism of action -- 11.12.2 Binding mode analysis -- 11.13 Dipyridamole -- 11.13.1 Mechanism of action -- 11.13.2 Binding mode analysis -- 11.14 Duvelisib -- 11.14.1 Mechanism of action -- 11.14.2 Binding mode analysis -- 11.15 Dyphylline -- 11.15.1 Mechanism of action -- 11.15.2 Binding mode analysis -- 11.16 Enprofylline -- 11.16.1 Mechanism of action -- 11.16.2 Binding mode analysis -- 11.17 Entecavir -- 11.17.1 Mechanism of action -- 11.17.2 Binding mode analysis -- 11.18 Fludarabine -- 11.18.1 Mechanism of action -- 11.18.2 Binding mode analysis -- 11.19 Ganciclovir -- 11.19.1 Mechanism of action -- 11.19.2 Binding mode analysis -- 11.20 Ibrutinib -- 11.20.1 Mechanism of action -- 11.20.2 Binding mode analysis -- 11.21 Idelalisib -- 11.21.1 Mechanism of action -- 11.21.2 Binding mode analysis -- 11.22 Istradefylline -- 11.22.1 Mechanism of action -- 11.22.2 Binding mode analysis -- 11.23 Methotrexate -- 11.23.1 Mechanism of action -- 11.23.2 Binding mode analysis -- 11.24 Nelarabine -- 11.24.1 Mechanism of action -- 11.24.2 Binding mode analysis -- 11.25 Palbociclib -- 11.25.1 Mechanism of action -- 11.25.2 Binding mode analysis -- 11.26 Pemetrexed -- 11.26.1 Mechanism of action -- 11.26.2 Binding mode analysis -- 11.27 PEMIROLAST -- 11.27.1 Mechanism of action -- 11.27.2 Binding mode analysis -- 11.28 Penciclovir -- 11.28.1 Mechanism of action -- 11.28.2 Binding mode analysis -- 11.29 Pentoxifylline -- 11.29.1 Mechanism of action -- 11.29.2 Binding mode analysis -- 11.30 Pralatrexate -- 11.30.1 Mechanism of action -- 11.30.2 Binding mode analysis -- 11.31 Regadenoson -- 11.31.1 Mechanism of action -- 11.31.2 Binding mode analysis -- 11.32 Ribociclib -- 11.32.1 Mechanism of action -- 11.32.2 Binding mode analysis -- 11.33 Risperidone -- 11.33.1 Mechanism of action -- 11.33.2 Binding mode analysis -- 11.34 Ruxolitinib. , 11.34.1 Mechanism of action.

Additional Edition: Print version: Kumar, Raj Fused Pyrimidine-Based Drug Discovery San Diego : Elsevier,c2022 ISBN 9780443186165

Language: English

UID:

Format: 1 online resource (372 pages) : , illustrations

ISBN: 0-08-102126-7 , 0-08-102082-1

Note: Front Cover -- Quality Management in Plastics Processing: Strategies, targets, techniques and tools -- Copyright -- Contents -- Preface -- 1 Introduction to quality management -- 1.1 Where we are going -- 1.2 The drivers for quality management -- 1.3 What is quality? -- 1.4 A short history of quality management -- 1.5 Quality management and not simply quality control -- 1.6 The importance of quality costs -- 1.7 Performance indicators -- 1.8 Quality management - where are you now? -- 1.9 Financial management - where are you now? -- 1.10 Technical management - where are you now? -- 1.11 Awareness and information - where are you now? -- Key tips -- 2 Organising for quality management -- 2.1 Getting started -- 2.2 Who is responsible? -- 2.3 Organising for quality assurance and control -- 2.4 Quality assurance and control organisation - where are you now? -- 2.5 Organising for quality improvement -- 2.6 Quality circles -- 2.7 Quality improvement teams - 1 -- 2.8 Quality improvement teams - 2 -- 2.9 Quality improvement organisation - where are you now? -- 2.10 Quality improvement projects -- 2.11 Quality improvement projects where - are you now? -- Key tips -- 3 Targeting and controlling the cost of poor quality -- 3.1 Quality costs - overview -- 3.2 Quality costs - the models -- 3.3 Quality costs - PAF model -- 3.4 Quality costs - process cost model -- 3.5 Quality costs - ABC model -- 3.6 Quality costs in plastics processing -- 3.7 Starting out -- 3.8 Integrating quality costs into the accounts -- 3.9 Setting targets -- 3.10 Reporting quality costs -- 3.11 Capital expenditure -- 3.12 Quality costs - where are you now? -- 3.13 Targeting and controlling where are you now? -- Key tips -- 4 Quality management systems and standards -- 4.1 What do you want your QMS to deliver? -- 4.2 Does a QMS deliver quality?. , 4.3 The 7 quality management principles and Plan-Do-Check-Act -- 4.4 The process approach - an overview -- 4.5 Manufacturing processes - a global view -- 4.6 Manufacturing processes - a detailed view -- 4.7 An overview of ISO 9001 -- 4.8 Organisation context requirements of ISO 9001 -- 4.9 Leadership requirements of ISO 9001 -- 4.10 Planning requirements of ISO 9001 -- 4.11 Support requirements of ISO 9001-1 -- 4.12 Support requirements of ISO 9001-2 -- 4.13 Operation requirements of ISO 9001-1 -- 4.14 Operation requirements of ISO 9001-2 -- 4.15 Performance evaluation requirements of ISO 9001 -- 4.16 Improvement requirements of ISO 9001 -- 4.17 Documented information -- 4.18 Quality planning -- 4.19 Risk-based thinking -- 4.20 Internal auditing -- 4.21 External auditing -- 4.22 Quality management standards - where are you now? -- Key tips -- 5 Statistical process control (SPC) -- 5.1 What is SPC? -- 5.2 Variable and attribute data, special and random variation -- 5.3 Sampling and the normal distribution -- 5.4 Can we make it OK? - capability and the normal distribution -- 5.5 Capability - spread -- 5.6 Capability - location -- 5.7 Are we making it OK? - variables and attributes control charts -- 5.8 Variables control charts - range and average -- 5.9 Using a simple variables control chart -- 5.10 Range chart alarms - normal variation and points outside the control limits -- 5.11 Range chart alarms - runs (above/below) and runs (up/down) -- 5.12 Range chart alarms - 2/3 of points in middle and 1/3 of points in the outer -- 5.13 Range chart alarms - other alarms -- 5.14 Average chart alarms - range control and points outside control limits -- 5.15 Average chart alarms - runs (above/below) and runs (up/down) -- 5.16 Average chart alarms - 2/3 of points in middle and 1/3 of points in the outer -- 5.17 Other control charts for variables. , 5.18 Variables control charts for individual measurements -- 5.19 Attributes control charts -- 5.20 Using attributes control charts -- 5.21 Control charts - where are you now? -- 5.22 The process capability study -- 5.23 Improving process capability -- 5.24 Capability studies - where are you now? -- 5.25 Implementing SPC in plastics processing - the process -- 5.26 Implementing SPC in plastics processing - a simple approach -- 5.27 Evaluating the effectiveness of SPC -- 5.28 Implementation - where are you now? -- Key tips -- 6 Acceptance sampling -- 6.1 Sampling systems approaches to quality -- 6.2 Sampling systems - general -- 6.3 Sampling systems - the choices -- 6.4 Using sampling systems -- 6.5 Sampling plans - the details -- 6.6 Sampling systems - where are you now? -- Key tips -- 7 Tools for quality management and improvement -- 7.1 Quality management and improvement tools -- 7.2 Flow charts -- 7.3 Check sheets -- 7.4 Cause and effect charts (root cause analysis) -- 7.5 Pareto analysis -- 7.6 Histograms -- 7.7 Scatter diagrams -- 7.8 Relations diagrams -- 7.9 Tree diagrams -- 7.10 Affinity diagrams -- 7.11 Matrix diagrams -- 7.12 Arrow diagrams -- 7.13 Process decision program charts -- 7.14 Quality tools - where are you now? -- Key tips -- 8 Design quality management -- 8.1 What makes a quality design? -- 8.2 The product design specification -- 8.3 Material and process selection -- 8.4 Basic design rules for plastics products -- 8.5 Design for manufacture -- 8.6 Design for assembly -- 8.7 Design for recycling and sustainability -- 8.8 Design fundamentals - where are you now? -- 8.9 The APQP design process -- 8.10 Quality function deployment (QFD) - the house of quality -- 8.11 Design FMEA - 1 -- 8.12 Design FMEA - 2 -- 8.13 Design and other drawings for plastics products -- 8.14 Plastic parts and tolerances. , 8.15 Designing quality into the product - 'off-line' quality control (DOE) -- 8.16 Design tools - where are you now? -- 8.17 Design teams and processes - where are you now? -- Key tips -- 9 Raw materials quality management -- 9.1 The basics -- 9.2 The materials team and raw material quality -- 9.3 The supplier management process -- 9.4 Supplier assessment - the basics -- 9.5 Supplier assessment - the extras -- 9.6 Quality improvement with suppliers -- 9.7 Purchase specifications -- 9.8 Price and cost at suppliers -- 9.9 Purchasing quality - where are you now? -- 9.10 Assessing inwards goods -- 9.11 AQL/SPC at inwards goods -- 9.12 Resin control - as delivered -- 9.13 Resin control - test pieces and products -- 9.14 Raw materials control - where are you now? -- Key tips -- 10 Processing quality management -- 10.1 Process design and development -- 10.2 Process and machinery FMEA -- 10.3 Control planning and control plans -- 10.4 Process setting -- 10.5 Product and process validation -- 10.6 Pre-control (zone charts) -- 10.7 Inspection, pre-control or control charts? -- 10.8 Engineering process control (EPC) -- 10.9 Integrating SPC and EPC -- 10.10 Injection moulding - scientific moulding -- 10.11 Injection moulding - multivariate analysis -- 10.12 Injection moulding - managing variables -- 10.13 Injection moulding - managing attributes -- 10.14 Extrusion - managing variables -- 10.15 Extrusion - using variables data -- 10.16 Extrusion - managing attributes -- 10.17 Blow moulding -- 10.18 Thermoforming -- 10.19 Rotational moulding -- 10.20 Processing systems - where are you now? -- 10.21 Processing - where are you now? -- Key tips -- 11 Operations quality management -- 11.1 Measuring sales quality -- 11.2 Improving sales quality -- 11.3 Accounting quality -- 11.4 General office quality -- 11.5 Operations - where are you now? -- Key tips -- Appendices. , Appendix 1 - Standard SPC formulae for variables and attributes charts -- Appendix 2 - Standard SPC constants for variables charts -- Appendix 3 - Sample standard SPC chart for variables (mean and range) -- Appendix 4 - Pz table for % nonconforming -- Appendix 5 - Precision and accuracy -- Appendix 6 - Measurement systems analysis -- Appendix 7 - Evaluating measurement systems -- Postscript -- Abbreviations and acronyms -- Back Cover.

Language: English

UID:

Format: 1 online resource (184 pages )

Edition: Second edition.

ISBN: 0-12-814979-5 , 0-12-814978-7

Note: Front Cover -- Planning for a Career in Biomedical and Life Sciences -- Copyright Page -- Dedication -- Contents -- About the Author -- Prologue (Second Edition) -- Inspiration and Passion Are Useful Companions on Your Journey -- 1 Inspired by Life Sciences -- 1.1 High School-A Place to Be Inspired -- 1.2 Lifestyle in the Bioscience Community -- Career Success Favors the Informed and Prepared Mind -- 2 Your Dynamic Training Path -- 2.1 Putting Your Best Foot Forward -- 2.2 Early Guidance -- 2.3 Charting Pathways to Success -- Dream Big and Settle for the Best You Can Accomplish -- 3 Your Undergraduate Studies -- 3.1 Choosing Your Undergraduate Education -- 3.2 The Value of Depth vs Breadth in Your Undergraduate Curriculum -- 3.3 Guidance in Successful Career Development -- 3.4 The Value of a Mentor -- 3.5 How to Behave as a Mentee -- 3.6 Achieving Value in Your Undergraduate Mentored Research Opportunity -- 3.7 Making the Most of Your Research Experience -- Well Informed Decisions Result in a Quality Graduate Experience -- 4 How to Select the Best Graduate Program for Your Needs -- 4.1 Assessment of the Quality of the Program -- 4.2 Important Information to Gather on Programs -- 4.3 Paying Attention to Personal Issues -- 4.4 Considerations of Family Issues -- 4.5 What to Be Aware of in Choosing International Studies -- 4.6 How to Select Your Supervisor -- 4.7 A Thorough List of Questions That Require Answers From Your Potential Supervisor and/or Students in the Laboratory -- 4.8 Student Views of Graduate Supervisors -- 4.9 How to Choose Your Research Projects -- 4.10 Translating Discovery Research -- Hard Work, Self-Reflection, Resilience and New Knowledge Go Hand in Hand in Career Development -- 5 Life in the Research Laboratory -- 5.1 Building Your Confidence -- 5.2 Tips on Developing People Skills -- 5.3 The Importance of Record Keeping. , 5.4 Preparing for Supervisor Meetings -- 5.5 Using Your Student Advisory Committee to Your Best Advantage -- 5.6 Know the Literature -- 5.7 Acquiring Communication Skills -- 5.8 Stay Focused -- 5.9 Achieving Resilience -- 5.10 Handling Failure -- 5.11 Learning to Face Rejection -- Independence in a Protected Environment -- 6 Postgraduate Studies: Preparing to Launch -- 6.1 Choosing a Postdoctoral Position -- 6.2 Your Postdoctoral Career Development Plan -- 6.3 How to Achieve Postdoctoral Success -- 6.4 Learning Management and the Business of Science -- 6.5 Understanding Manuscript and Grant Review -- Life Continues But the Rules Are Different -- 7 Your First Job: Choosing Well in Academia -- 7.1 Exploring Job Prospects -- 7.2 Academic Job Description -- 7.3 Preparing Your Academic Application -- 7.4 How to Select Referees -- 7.5 Assessing Teaching -- 7.6 How to Behave on Your Interview Visit -- 7.7 Learn to Negotiate Effectively -- 7.8 How to Make the Best Start-Up Fund Proposal -- 7.9 Salary and Benefits Need Careful Consideration -- 7.10 How to Transition to Your Own Laboratory -- 7.11 Setting Up Your Own Laboratory -- 7.12 Hiring Trainees and Staff -- Your Initial Employment Is Still Part of the Journey and Not Your Destination -- 8 Your Next 10 Years: Tenure and Promotion -- 8.1 Achieving Tenure and Academic Promotion -- 8.2 How to Navigate Your Environment -- 8.3 The Value of Scientific Networking -- 8.4 Navigating Institutional Priorities -- 8.5 Management of Your Service Activities -- 8.6 Teaching Assessment -- 8.7 Achieving a Successful Research Program -- 8.8 Strategies for Research Funding -- 8.9 Understanding University-Industry Collaborations -- 8.10 How to Establish Successful Productivity -- 8.11 Applying for Merit Awards -- 8.12 Your Progress in a Research Institute -- 8.13 Why Advocacy Is Required. , Teaching and Research Institutions Are Valuable Community Resources and Require Constant Care -- 9 The Institutional Challenge to Train and Support Academic Biomedical Scientists -- 9.1 Institutional Excellence -- 9.2 Institutional Teaching -- 9.3 Institutional Research -- Academic Leadership Is Tough and Rewarding -- 10 Into the Future: So You Want to Be an Academic Leader -- 10.1 Academic Leadership -- 10.2 The Faces of Leadership -- 10.3 Delivering Leadership -- 10.4 How to Achieve Effective Communication -- 10.5 Availability of the Leader -- 10.6 Health and Safety -- 10.7 Handling Urgent Situations -- Enjoy Your Initial Employment, the Platform for Launching Your Career -- 11 Your First Job: Preparing and Choosing Well for Nonacademic Careers -- 11.1 How to Train for a Nonacademic Career -- 11.2 Life Sciences Platform -- 11.3 Job Choices -- 11.4 Placements and Internships -- 11.5 Head Hunters -- 11.6 Advancement in Nonacademic Careers -- The Golden Rules for Success -- Appendix: Questions and Answers on Important Issues -- 1. As a senior high school student, is it advisable to participate in a university organized life science/biomedical research program that provides high school students with a glimpse of research and university life? -- 2. Is there university help for high school science fairs? -- 3. Should I seek out several research experiences as an undergraduate student or should I stick to one laboratory? -- 4. Extracurricular activities take time. Are they worth it? -- 5. Should I go to graduate school directly after my undergraduate program? -- 6. Should it be hard to speak frankly to my supervisor? -- 7. What can I do if I realize my supervisor is not the right fit for me? -- 8. What is my responsibility as a student to maintain research integrity? -- 9. Is occupational health and safety really important?. , 10. How can email and social media create problems for students? -- 11. What if I like both research and clinical medicine? -- 12. Can I move from industry and/or the public sector back into academia? -- 13. How do I approach new evolving careers at the interface of disciplines? -- 14. Do I Need to Develop a Fallback Plan (Plan B)? -- Epilogue -- Index -- Back Cover.

Language: English