Format:
Online Ressource (PDF, 65748 KB, 1200 S.)
Edition:
1. Aufl.
Edition:
Online-Ausg. 2013 Electronic reproduction; Available via World Wide Web
ISBN:
3527332367
,
3527658890
,
3527658874
,
3527658866
,
9783527332366
,
9783527658893
,
9783527658879
,
9783527658862
Content:
A much-needed overview reflecting the developments over the past five years, this is the most comprehensive handbook on organocatalysis. As such, all relevant catalyst systems are discussed in detail, as well as key strategies, reaction types, and important applications in total synthesis. The first two volumes cover catalyst structures andfundamental activation types. These chapters allow readers to familiarize themselves with the relatively complex interactions that make organocatalytic reactions selective; to gain an insight into the most efficient catalyst types; and to understand the importance of physical parameters that influence reactivity and selectivity. Volume three is structured around reaction types, i.e. nucleophile additions to C=X and C=C bonds; Friedel-Crafts reactions, organocatalytic sigmatropic reactions, regioselective reactions and desymmetrization strategies, ring-forming reactions, multicomponent (domino) reactions, multicatalyst systems and the application of organocatalytic reactions in multistep synthesis are discussed. An appendix recollecting catalyst structures with the adequate cross-references to the corresponding chapters rounds off the book. With its contributions written by pioneers of the organocatalysis field, this book provides non-specialists with an introduction to the topic as well as serving as a valuable source for researchers in academia and industry searching for an up-to-date and comprehensive overview of this promising area of synthetic organic chemistry. Peter I. Dalkostudied chemistry at the Budapest Technical University (Hungary) and graduated from Paris XI University (France) under the supervision of Stephan D. Géro. After undertaking postdoctoral research with Sir Derek H. Barton at Texas AM University (USA) and Yoshito Kishi at Harvard University he joined Janine Cossy's research group at the ESPCI in Paris. He is now a Research Director at the French Scientific Research Council (CNRS) at the Medical Faculty of Paris Descartes University. His research is focused on total synthesis of structurally complex natural products, development of organocatalytic reactions for synthesis and developing micro- and nanoscale technologies for biomedical researches.
Note:
Description based upon print version of record
,
Cover; Related Titles; Title page; Copyright page; Contents; Foreword; Preface; List of Contributors; Abbreviations; Volume 1: Privileged Catalysts; Part I: Amino Acid-Derived Catalysts; 1: Proline-Related Secondary Amine Catalysts and Applications; 1.1 Introduction; 1.2 Prolinamide and Related Catalysts; 1.3 Prolinamine and Related Catalysts; 1.4 Proline Tetrazole and Related Catalysts; 1.5 Prolinamine Sulfonamide and Related Catalysts; 1.6 Prolinamine Thiourea and Related Catalysts; 1.7 Miscellaneous; 1.8 Conclusions; Acknowledgments; References; 2: TMS-Prolinol Catalyst in Organocatalysis
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2.1 Introduction2.2 Enamine Activation; 2.3 Iminium-Ion Activation; 2.4 Cascade Reactions; 2.5 Dienamine Activation; 2.6 Trienamine Activation; 2.7 Summary and Conclusions; References; 3: Non-Proline Amino Acid Catalysts; 3.1 Introduction; 3.2 Primary Amino Acids in Amino Catalysis; 3.3 Primary Amino Acid-Derived Organic Catalysts; 3.3.1 Unmodified Amino Acids; 3.3.2 Protected Primary Amino Acids; 3.3.3 Primary Amino Acid-Derived Diamine Catalysts; 3.3.4 Other Primary Amino Acid Catalysts; 3.4 Applications of Non-Proline Primary Amino Acid Catalysts; 3.4.1 Aldol Reaction
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3.4.2 Mannich Reaction3.4.3 Michael Addition; 3.4.4 Other Reactions; 3.5 Conclusions; Acknowledgments; References; 4: Chiral Imidazolidinone (MacMillan's) Catalyst; 4.1 Introduction; 4.2 Enamine Catalysis; 4.3 Iminium Catalysis; 4.4 Cascade Reaction - Merging Iminium and Enamine Catalysis; References; 5: Oligopeptides as Modular Organocatalytic Scaffolds; 5.1 Introduction; 5.2 C-C Bond Forming Reactions; 5.2.1 Aldol Reactions; 5.2.2 Michael Reactions; 5.2.3 Morita-Baylis-Hillman Reactions; 5.2.4 Hydrocyanation of Aldehydes; 5.3 Asymmetric Acylations; 5.4 Asymmetric Phosphorylations
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5.5 Enantioselective Oxidations5.6 Hydrolytic Reactions; 5.7 Summary and Conclusions; References; Part II: Non-Amino Acid-Derived Catalysts; 6: Cinchonas and Cupreidines; 6.1 Introduction; 6.2 Cinchona Alkaloid Derivatives; 6.3 Natural Cinchona Alkaloids, Cupreine, and Cupreidine; 6.3.1 Structural Properties; 6.3.2 Catalysis with Natural Cinchona Alkaloids; 6.3.3 Catalysis with Cupreine and Cupreidine; 6.4 Cinchona Alkaloids with an Ether or Ester Group at C9; 6.4.1 Structural Properties; 6.4.2 Catalysis with C9 Ethers of Natural Cinchona Alkaloids
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6.4.3 Catalysis with C9 Ethers of Cupreine and Cupreidine6.4.4 Catalysis with C9 Esters; 6.5 Cinchona Alkaloid Derivatives with a Sulfonamide, Urea, Thiourea, Squaramide, or Guanidine Function; 6.5.1 Structural Properties; 6.5.2 Catalysis with C9 and C6′ Thiourea Derivatives; 6.5.3 Catalysis with C9 Sulfonamide, Squaramide, and Guanidine Derivatives; 6.6 Cinchona Alkaloids with a Primary Amine Group at C9; 6.6.1 Structural Properties; 6.6.2 Catalysis with C9 Amino Derivatives; 6.7 Cinchona Alkaloids in Phase-Transfer Catalysis; 6.8 Ether Bridged Dimers
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6.9 Some Novel Cinchona Alkaloid Derivatives
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Electronic reproduction; Available via World Wide Web
Additional Edition:
ISBN 3527658882
Additional Edition:
ISBN 9783527658886
Additional Edition:
Erscheint auch als Druck-Ausgabe Comprehensive enantioselective organocatalysis Weinheim : Wiley-VCH, 2013 ISBN 3527332367
Additional Edition:
ISBN 9783527332366
Language:
English
Subjects:
Chemistry/Pharmacy
Keywords:
Electronic books
DOI:
10.1002/9783527658862
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