UID:
almafu_9959329137602883
Format:
1 online resource :
,
illustrations (some color)
ISBN:
9783527678174
,
3527678174
,
9783527678198
,
3527678190
,
9781322214368
,
1322214360
,
9783527332373
,
3527332375
,
9783527678181
,
3527678182
Content:
Comprehensive and up-to-date, this book focuses on the latest advances in the field, such as newly developed techniques, more environmentally benign processes, broadened scopes, and completely novel MCRs. In addition to carbene-promoted MCRs and frequently applied metal-catalyzed MCRs, it also covers recently developed catalytic enantioselective variants as well as MCR in drug discovery and for the synthesis of heterocyclic molecules and macrocycles. Edited by the leading experts and with a list of authors reading like a ""who's who"" in multicomponent reaction chemistry, this is definitely a.
Note:
Multicomponent Reactions in Organic Synthesis; Contents; List of Contributors; Preface; 1. General Introduction to MCRs: Past, Present, and Future; 1.1 Introduction; 1.2 Advances in Chemistry; 1.3 Total Syntheses; 1.4 Applications in Pharmaceutical and Agrochemical Industry; 1.5 Materials; 1.6 Outlook; References; 2. Discovery of MCRs; 2.1 General Introduction; 2.2 The Concept; 2.3 The Reaction Design Concept; 2.3.1 Single Reactant Replacement; 2.3.2 Modular Reaction Sequences; 2.3.3 Condition-Based Divergence; 2.3.4 Union of MCRs; 2.4 Multicomponent Reactions and Biocatalysis.
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2.4.1 Multicomponent Reactions and (Dynamic) Enzymatic Kinetic Resolution2.4.2 Multicomponent Reactions and Enzymatic Desymmetrization; 2.5 Multicomponent Reactions in Green Pharmaceutical Production; 2.6 Conclusions; Acknowledgments; References; 3. Aryne-Based Multicomponent Reactions; 3.1 Introduction; 3.2 Multicomponent Reactions of Arynes via Electrophilic Coupling; 3.2.1 Multicomponent Reactions under Neutral Conditions; 3.2.1.1 Isocyanide-Based Multicomponent Reactions; 3.2.1.2 Imine-Based Multicomponent Reactions; 3.2.1.3 Amine-Based Multicomponent Reactions.
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4.2.1 Phenols and Thiophenols4.2.2 Six-Membered Ring Hydroxy Heteroaromatics and Related Mercaptans; 4.2.3 Five-Membered Ring Hydroxy Heteroaromatic and Related Mercaptans; 4.2.4 Related Couplings with Enol Derivatives; 4.2.5 The Joullié-Smiles Coupling; 4.2.6 The Passerini-Smiles Reaction; 4.3 Ugi-Smiles Postcondensations; 4.3.1 Postcondensations Involving Reduction of the Nitro Group; 4.3.2 Transformations of Ugi-Smiles Thioamides; 4.3.3 Postcondensations Involving Transition Metal-Catalyzed Processes; 4.3.4 Reactivity of the Peptidyl Unit; 4.3.5 Radical Reactions; 4.3.6 Cycloaddition.
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4.4 ConclusionsReferences; 5. 1,3-Dicarbonyls in Multicomponent Reactions; 5.1 Introduction; 5.2 Achiral and Racemic MCRs; 5.2.1 Involving One Pronucleophilic Reactive Site; 5.2.2 Involving Two Reactive Sites; 5.2.2.1 Two Nucleophilic Sites; 5.2.2.2 One Pronucleophilic Site and One Electrophilic Site; 5.2.3 Involving Three Reactive Sites; 5.2.4 Involving Four Reactive Sites; 5.3 Enantioselective MCRs; 5.3.1 Involving One Reactive Site; 5.3.2 Involving Two Reactive Sites; 5.3.3 Involving Three Reactive Sites; 5.4 Conclusions and Outlook; References; 6. Functionalization of Heterocycles by MCRs.
Additional Edition:
Print version: Zhu, Jieping. Multicomponent Reactions in Organic Synthesis. Hoboken : Wiley, ©2014 ISBN 9783527332373
Language:
English
Keywords:
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Electronic books.
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Electronic books.
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Electronic books.
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Electronic books.
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Electronic books.
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527678174
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527678174
URL:
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527678174
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