Umfang:
Online-Ressource (X, 253p. 19 illus., 16 illus. in color, digital)
ISBN:
9783642236907
Serie:
Current Topics in Microbiology and Immunology 351
Inhalt:
This volume of Current Topics in Microbiology and Immunology covers diverse topics related to intradermal immunization. The chapters highlight the effectiveness of intradermal immunization in experimental animal models or in clinical practice, all supporting the view that intradermal immunization is at least as good as other immunization routes. Keeping in mind that current vaccines are not specially designed for intradermal immunization, but show comparable efficiency even at reduced dosages, this underlines the great potential for the skin as a vaccination site. Hopefully, the overview in th
Anmerkung:
Includes bibliographical references and index
,
Intradermal Immunization; Preface; Contents; Contributors; 115 Understanding the Murine Cutaneous Dendritic Cell Network to Improve Intradermal Vaccination Strategies; Abstract; 1…Introduction; 2…The Skin Dendritic Cell Network; 2.1 Langerhans Cells; 2.2 Dermal DC Subsets in Steady-State; 2.3 Localization of Dermal DC Subsets; 2.4 Inflammatory Dermal DC Subsets; 3…Homeostasis of Cutaneous DCs; 3.1 Proliferation; 3.2 Migration; 3.3 Origin of Cutaneous DCs; 3.4 Differentiation Program of Cutaneous DC Subsets; 3.5 The LC Exception; 4…Functional Specialization of Cutaneous DC Subsets
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4.1 Challenging the LC Paradigm4.2 Lessons from Animal Models; 5…Perspectives: Implications for Vaccination; 5.1 Antigen Delivery; 5.2 DC Targeting; 5.3 DC Poietins as Adjuvants; 5.4 Visualization of DC Function: A Systematic Approach for Better Vaccines; 6…Conclusion; References; 169 Insight into the Immunobiology of Human Skin and Functional Specialization of Skin Dendritic Cell Subsets to Innovate Intradermal Vaccination Design; Abstract; 1…Introduction; 1.1 Skin as Defense Organ; 1.2 Skin as Target for Vaccine Administration; 2…Immunobiology of Human Skin; 2.1 Functional Anatomy
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2.2 Skin-Associated Innate and Adaptive Immunology3…DCs are Key Regulators of Immune Responses; 3.1 Detection of Danger; 3.2 Uptake and Processing of Antigen; 3.3 Translation of Sensed Danger to Adequate T-cell Responses; 4…Human DC Subsets; 4.1 Surface Markers; 4.2 Human Blood DC Subsets; 4.3 Human Lymphoid Tissue DC Subsets; 5…DC Subsets in Human Skin; 5.1 Epidermal Langerhans cells; 5.2 Dermal DCs; 5.3 Dermal Macrophages; 5.4 DC Subsets in Inflamed Skin; 5.4.1 Plasmacytoid DCs; 5.4.2 IDECs; 5.4.3 SlanDCs; 5.4.4 Tip-DCs; 6…Relationship Between DC Subsets; 6.1 Ontogeny of Human DCs
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6.2 Functional Specialization of Cutaneous DCs in Humans7…Intradermal Vaccination and Skin DCs; 7.1 Which Skin DC Subset is Important?; 7.2 Improvement of Intradermal Vaccination; 7.2.1 Targeting Vaccines to DC Subsets; 7.2.2 Harnessing and Fine-Tuning DC Function with Adjuvants; 8…Concluding Remarks and Perspectives; References; 123 Delivery Systems for Intradermal Vaccination; Abstract; 1…Introduction; 1.1 Immunologic Motivation for Intradermal Delivery; 1.2 Current Intradermal Vaccines; 1.2.1 Smallpox; 1.2.2 BCG; 1.2.3 Rabies; 1.3 Clinical Studies on other Intradermal Vaccines
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1.3.1 Influenza1.3.2 Hepatitis B; 1.3.3 Hepatitis A; 1.3.4 Polio; 1.3.5 Measles; 1.3.6 Yellow Fever; 1.3.7 Others; 1.4 Difficulties to Make Intradermal Delivery More Widespread; 2…Injecting into the Skin; 2.1 Hypodermic Needles: Mantoux Intradermal Injection; 2.2 Single Hollow Microneedles; 2.2.1 Preclinical Studies; 2.2.2 Clinical Trials; 2.3 Arrays of Hollow Microneedles; 3…Shooting into the Skin; 3.1 Jet Injector; 3.1.1 History; 3.1.2 Recent Intradermal Vaccination Clinical Studies; 3.2 Projectile Delivery; 4…Piercing into the Skin; 4.1 Bifurcated Needles; 4.2 Solid Microneedles
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4.2.1 Coated Microneedles
Weitere Ausg.:
ISBN 9783642236891
Weitere Ausg.:
Buchausg. u.d.T. Intradermal immunization Berlin : Springer, 2012 ISBN 9783642236891
Weitere Ausg.:
ISBN 3642236898
Sprache:
Englisch
Fachgebiete:
Medizin
Schlagwort(e):
Intrakutanimpfung
;
Aufsatzsammlung
DOI:
10.1007/978-3-642-23690-7
URL:
Volltext
(lizenzpflichtig)
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