Format:
Online-Ressource (XXIV, 371 p, digital)
ISBN:
9783764377694
Series Statement:
SpringerLink
Content:
In the late nineteenth century, David Paul von Hansemann coined phrases that have remained the basis of descriptive terms concerning the microscopical appearances of tumors ever since, yet his work is rarely mentioned today. This book presents translations of all the relevant German texts and analyses the background and context of Hansemann's theories. It shows that some of Hansemann's ideas may still be relevant to cancer research today.
Content:
"In 1890, just a few years after the discovery of the chromosomes, David Paul Hansemann, a pathologist-in-training with the famous Rudolph Virchow in Berlin, produced a theory of the pathogenesis of cancer involving the key current concept: that the first change which occurs in cancer is an alteration of the hereditary material of a normal cell at the site where the cancerous process begins. In the process of linking cancer to chromosomal material, Hansemann coined the terms ""anaplasia"" and ""dedifferentiation"". These terms have remained the basis of descriptive terms concerning the microscopical appearances of tumours ever since. Nevertheless, despite the popularity of his terminology, Hansemann's ideas were attacked vigorously by almost all proponents of rival theories of the nature of cancer. Partly due to these disputes during his life-time, and partly due to other factors, interest in von Hansemann's ideas diminished during the twentieth century and his works are rarely mentioned today. This book presents translations of all the relevant German texts, and analyses the background and context of Hansemann's theories as well as the reasons why he was almost completely forgotten. It shows that some of Hansemann's ideas may still be relevant to cancer research today, and that he deserves to be remembered in relation to cancer as Vordenker unter den führenden Denkern seiner Zeit - The foremost of the leading thinkers of his time."
Note:
Bibliography of David Paul von Hausemann
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Includes bibliographical references (p. 347-361) and index
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CONTENTS; Preface and Overview; Acknowledgements; Notes on the Works and Translations; Table of Chronology; Part I Background; Family, education and career; Family background; Education; Rudolph Virchow as a teacher; Post-graduate career; Notes to chapter 1; Introduction; Influence of the Ancient Greeks; German philosophy and literature after the Reformation; Streitkultur; Characteristics of Virchow's thinking; Virchow's "Cellular Pathology" as a philosophy of pathology; Darwinism in Germany; Altruism,"cellular altruism"and"biologistic sociology"; Militarism and Junkertum; Notes to chapter 2
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IntroductionMicroscopy; Normal histology; Virchow's "Cellular Pathology"- an analysis; Virchow and the origin and lineage fidelity (an aspect of ""specificity"") of cells; Embryology; Heredity at the level of the whole individual (ancestral heredity); Cellular heredity in embryonic development; Heredity in cell populations which turn over in adults; Applications of the word "differentiation"; "Capacity for independent existence"; in normal, pathological and experimental studies; Notes to chapter 3; Introduction; The concept of "plasias"; Virchow's concepts of tumours
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"Embryonal" theories of cancer"Egg-like" features of cancer cells; "Fecundation/fertilisation/fusion" theories; The role of mitosis in heredity at the time of Hansemann; Chromosomes in tumour cells; Difficulties of diagnosis of tumours by histopathology in the 1890s: the case of the laryngeal cancer of Emperor Friedrich III; Notes to chapter 4; Introduction; The original version of the theory (Hansemann 1890a); Further analysis of the oogenic model; Further analysis of de-differentiation and numbers of chromosomes in tumour cells; Later modifications to the detail of the theories
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Hansemann on mitoses and chromosomes in generalHansemann on abnormal mitoses and chromosomes in pathological cells; The problem of excessive growth of tumour cells; The application of anaplasia and de-differentiation to the diagnosis of malignant tumours; Hansemann's philosophy; Notes to chapter 5; Ribbert and the theory of "control by connective tissue"; Lubarsch; Borst; O.Israel; Other critics: Beneke,Wolff; Boveri's ideas were similar to Hansemann's; Hauser; Farmer, Moore and Walker; Bashford; Other reviewers 1900-1919; Whitman - overlooked insights; Reviewers in the 1920s and after
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Subsequent developments in cancer researchWhy was Hansemann forgotten? - more fruitful fields of research; Why was Hansemann forgotten? - scientific faults of his work; Why was Hansemann forgotten? - other factors; What might have been; Notes to chapter 6; Part II Translations; Chapter 7; On the asymmetrical division of cells in epithelial carcinomata and their biological importance (1890a); Chapter 8; On pathological mitoses (1891a); Chapter 9; Karyokinesis and "Cellular Pathology" (1891c); Chapter 10; On the anaplasia of tumour cells and asymmetric mitosis (1892a); Chapter 11
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"Studies on the Specificity, the Altruism and the Anaplasia of cells with Special Reference to Tumours" (1893c)
Additional Edition:
ISBN 9783764377687
Additional Edition:
Buchausg. u.d.T. Bignold, Leon P., 1947 - David Paul von Hansemann: contributions to oncology ; context, comments and translations Basel : Birkhäuser, 2007 ISBN 3764377682
Additional Edition:
ISBN 9783764377687
Language:
English
Subjects:
Medicine
Keywords:
Hansemann, David von 1858-1920
;
Onkologie
;
Hansemann, David von 1858-1920
;
Onkologie
DOI:
10.1007/978-3-7643-7769-4
URL:
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