Umfang:
Online-Ressource
,
Ill., graph. Darst.
Ausgabe:
Online-Ausg. 2007 Springer eBook Collection. Chemistry and Materials Science Electronic reproduction; Available via World Wide Web
ISBN:
9781402044076
Serie:
RSC biomolecular sciences [3]
Inhalt:
This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions.
Inhalt:
Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book. The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised worldwide. The use of 3-D protein structures in new, Fragment-based, approaches to drug discovery are described in some detail. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions. In addition, developments in computational chemistry methodology are covered together with an assessment of practical applications.
Anmerkung:
Includes bibliographical references and index
,
Front Matter; Five Years of Increasing Structural Biology Throughput - A Retrospective Analysis; Protein Production for Structural Genomics - Strategies for the Next Phase; Introduction to Fragment Screening; Fragment-Based NMR Screening in Lead Discovery; Fragment-Based Screening by X-ray Crystallography; Scaffold-Based Drug Discovery; Biophysical Methods; Illustration of Current Challenges in Molecular Docking; Scoring Functions; Back Matter
,
Electronic reproduction; Available via World Wide Web
Weitere Ausg.:
ISBN 9781402044069
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe Structure-based drug discovery Dordrecht [u.a.] : Springer, 2007 ISBN 1402044062
Weitere Ausg.:
ISBN 9781402044069
Sprache:
Englisch
Fachgebiete:
Chemie/Pharmazie
Schlagwort(e):
Arzneimitteldesign
;
Struktur-Aktivitäts-Beziehung
;
Arzneimittelentwicklung
;
Aufsatzsammlung
DOI:
10.1007/1-4020-4407-0
URL:
Volltext
(lizenzpflichtig)
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