UID:
almafu_9960073267402883
Umfang:
1 online resource (793 p.)
Ausgabe:
1st ed.
ISBN:
1-281-18648-1
,
9786611186487
,
0-08-052905-4
Inhalt:
The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemis
Anmerkung:
Description based upon print version of record.
,
Front Cover; Chemistry and Biology of Heparin and Heparan Sulfate; Copyright Page; Contents; Preface; Contributors; Chapter 1. Structure and Active Domains of Heparin; I .Introduction; II. Heparin Components; III. Molecular Conformation of Heparin Residues and Sequences; IV. Heparin Domains Involved in Biological Interactions; V. Molecular Conformation of Active Domains; VI. Conclusions; Chapter 2. Structure and Function of Cell Associated and Pericellular Heparan Sulfate Proteoglycans; I. Introduction; II. Heparan Sulfate Synthesis
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III. Molecular Structure of Heparan Sulfate and Binding Ligands IV. Types of Heparan Sulfate Proteoglycans; V. Syndecans; VI. Role of Syndecan in Development; VII. Glypicans; VIII. Roles of Glypican in Tissue Development; IX. Betaglycan and CD44; X. Pericellular Heparan Sulfate Proteoglycans; XI. Role in Disease Pathogenesis; XII. Summary; Chapter 3. Methods for Structural Analysis of Heparin and Heparan Sulfate; I. Introduction; II. Structure of Heparin and Heparan Sulfate; III. Separation-Based Analysis of Heparin and Heparan Sulfate
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IV. Mass Spectrometric Analysis of Heparin and Heparan SulfateV. Nuclear Magnetic Resonance Analysis of Heparin and Heparan Sulfate; VI. New Methodologies for Structural Analysis of Heparin and Heparan Sulfate; VII. Summary and Conclusions; Chapter 4. Synthetic Approach to Define Structure-Activity Relationship of Heparin and Heparan Sulfate; I. Introduction; II. Biosynthesis; III. Structure of Heparin/Heparan Sulfate; IV. Chemical Synthesis of Defined Heparin Oligosaccharides; V. Summary and Outlook; Chapter 5. Biochemical and Pharmacological Rationale for Synthetic Heparin Polysaccharides
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I. Introduction II. Biological Activities and Mechanisms of Action of Heparin; III. Fractionation and Fragmentation of Heparin; IV. Elucidation of the Minimum Heparin Sequence for Binding to AT; V. Synthesis of the Pentasaccharide Representing the Critical Binding Site of Heparin to AT; VI. Pre-Clinical Pharmacology of Fondaparinux; VII. Clinical Trials of Fondaparinux; VIII. Derivatives of Pentasaccharide; IX. Summary; Chapter 6.Separation and Sequencing of Heparin and Heparan Sulphate Saccharides; I. Introduction; II. Separation of Heparin and Heparan Sulphate Oligosaccharides
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III. Heparin and Heparan Sulphate Sequencing IV. Discussion; Chapter 7. Biosynthesis of Heparin and Heparan Sulfate; I. Introduction; II. Biosynthetic Enzymes and Transporters of Uridine Diphosphate- Sugars and 3'-Phosphoadenosine 5'-Phosphosulfate; III. Biosynthesis of Heparin and Heparan Sulfate Backbones; IV. Modification of the Sugar Backbones of Heparin and Heparan Sulfate; V. Conclusions; Chapter 8. Remodeling of Heparan Sulfation by Extracellular Endosulfatases; I. Introduction; II. Identification of Sulf Enzymes; III. Expression and Enzymatic Activity of Sulf Enzymes
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IV. Signaling Regulatory Functions of Extracellular Sulfatases
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English
Weitere Ausg.:
ISBN 0-08-044859-3
Sprache:
Englisch
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