UID:
almafu_9960072251802883
Format:
1 online resource (343 p.)
ISBN:
1-281-01067-7
,
9786611010676
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0-08-049375-0
Series Statement:
Advances in protein chemistry, v. 61
Content:
Protein modules engage in a multitude of interactions with one another and with other cellular components, notably with DNA. These interactions are a central aspect of protein function of great relevance in the post-genomic era. This volume describes a panel of approaches for analyzing protein modules and their interactions, ranging from bioinformatics to physical chemistry, to biochemistry, with an emphasis on the structure-function relationship in protein-protein complexes involved in cellular processes including signal transduction.Key Features* Comprehensive overview of differe
Note:
Description based upon print version of record.
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Front Cover; Advances in Protein Chemistry; Copyright Page; Contents; Chapter 1.Introduction; I. Protein Modules and Protein-Protein Interaction: Towards a Global View; Web Sites; References; Chapter 2. Structural Basis of Macromolecular Recognition; I. Introduction; II. Geomatric and Chemical Features of Macromlecular Recognition; III. Classification of Protein-Protein and Protein-DNA Complexes; IV. Energetics of Magromolecular Recognition; V. Computational Approaches for Predicting and Simulating Protein-Protein Interaction; VI. Concluding Remarks; Web Sites; References
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Chapter 3. Sequences Analysis of Multidomain Proteins: Past Perspectives and Future DirectionsI. Identification of Novel Protein Domain Families; II. Methods for Classifying Protein Domain Families; III. From Domain Classification to Domain context; IV. Genome-Wide Analysis: New Quality in Domain Resarch; V. Conclusion; References; Chapter 4. Identification of Transiently Interacting Proteins and of Stable Protein Complexes; I. Introduction; II. Genetic Approaches; III. Biological Methods; IV. Biochemical Methods; V. Validation of Interactions
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VI. Characterization of Interacting Subunits and Dissection of Interaction DomainReferences; Chapter 5. Molecular Recognition in Antibody-Antigen Complexes; I. Introduction; II. Structure of Antibody-Antigen Interfaces; III. Antibody Cross-Reactivity and Molecular Mimicry; IV. Thermodynamic Mapping of Antigen-Antibody Interfaces; V. Dissection of Binding Energetics in Antigen-Antibody Interfaces Using Dobule-Mutant Cycles; VI. Accommodation of Mutations in Antigen-Antibody Interfaces; VII. Functional Roles for Protein Plasticity in Antigen Recognition; VIII. Conclusions; References
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Chapter 6. Molecular Recognition by SH2 DomainsI. Introduction; II. Single SH2 Domain Structure; III. Functional Analysis of Single SH2 Domain Binding; IV. Structure and Function of SH2 Domain in the Context of Other Protein Modules; V. Unusual SH2 Domain Interactions; VI. SH2 Domain as Drugs Targets; VII. Summary; References; Chapter 7. How SH3 Domain Recognize Proline; I. Introduction; II. Proline and Polyproline Type II Helices; III. The SH3 Domain: A Model System to Understand Interactions Mediated by Proline-Rich PPH Helices; References
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Chapter 8. Structural Biology of elF4F: mRNA Recognition and Preparation in Eukaryotic Translation InitiationI. Introduction; II. Structural Features of Eukaryotic mRNAs; III. General Mechanisms of Cellular, Cap-Dependent Translation Initiation; IV. HEAT Repeats within eIF4G Direct Assembly of Translation Machinery; V. Preparation of the mRNA 5'-UTR for Small Ribosomal Subunit Binding; VI. Conclusion and Perspectives; References; AUTHOR INDEX; SUBJECT INDEX
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English
Additional Edition:
ISBN 0-12-034261-8
Language:
English
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