UID:
almafu_9958132556202883
Format:
1 online resource (607 p.)
ISBN:
9786611011390
,
9781281011398
,
1281011398
,
9780080497105
,
0080497101
Series Statement:
Methods in enzymology, v. 369
Content:
Combinatorial Chemistry encompasses both the design of compounds for specific pharmacological use and the screening of molecules in high throughput automated tests to find active agents with specific functions.*Analytical techniques*Direct sorting split and pool combinatorial synthesis*Linkers and their applications*Microwave assisted synthesis*Oligosaccharide chemistry*Peptide Synthesis and Screening*Polymer assisted approaches*Small molecule and heterocycle synthesis
Note:
Description based upon print version of record.
,
Cover; Table of Contents; Contributors to Volume 369; Preface; Volumes in Series; Section I: Analytical Techniques; Chapter 1. High-Throughput Parallel LC/UV/MS Analysis of Combinatorial Libraries; Chapter 2. Qualitative Colorimetric Tests for Solid Phase Synthesis; Section II: Directed Sorting Split-and-Pool Combinatorial Synthesis; Chapter 3. A Review of Solid-Phase Organic Synthesis on SynPhase' Lanterns and SynPhase' Crowns; Chapter 4. Directed Sorting Approach for the Synthesis of Large Combinatorial Libraries of Discrete Compounds
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Chapter 5. Split-Mix Synthesis Using Macroscopic Solid Support UnitsChapter 6. The Encore Technique: A Novel Approach to Directed Split-and-Pool Combinatorial Synthesis; Section III: Linkers and Their Applications; Chapter 7. Multifunctional Linkers as an Efficient Tool for the Synthesis of Diverse Small Molecule Libraries: The Triazene Anchors; Chapter 8. The Development and Application of Tetrafluorophenol-Activated Resins for Rapid Amine Derivatization; Chapter 9. The Traceless Solid-Phase Synthesis of Organic Molecules
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Chapter 10. Unnatural Diamino Acid Derivatives as Scaffolds for Creating Diversity and as Linkers for Simplifying Screening in Chemical LibrariesSection IV: Microwave-Assisted Synthesis; Chapter 11. Building Dihydropyrimidine Libraries via Microwave-Assisted Biginelli Multicomponent Reactions; Chapter 12. Microwave-Assisted Solid-Phase Organic Synthesis (MA-SPOS) of Oxazolidinone Antimicrobials; Section V: Oligosaccharide Chemistry; Chapter 13. Automated Synthesis of Polysaccharides; Chapter 14. Solid-Phase Oligosaccharide Chemistry and Its Application to Library Synthesis
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Section VI: Peptide Synthesis and ScreeningChapter 15. Design, Synthesis, Screening, and Decoding of Encoded One-Bead One-Compound Peptidomimetic and Small Molecule Combinatorial Libraries; Chapter 16. Intelligent Design in Combinatorial Chemistry: Use of Designed Peptide Libraries to Explore Secondary and Tertiary Structures in Peptides and Proteins; Chapter 17. Synthesis and Screening of ''One-Bead One- Compound'' Combinatorial Peptide Libraries; Chapter 18. Synthetic Combinatorial Libraries as an Alternative Strategy for the Development of Novel Treatments for Infectious Diseases
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Section VII: Polymer-Assisted ApproachesChapter 19. Advances in the Applications of Polymer- Supported Reagents for Organic Synthesis; Chapter 20. Advanced Polymer Reagents Based on Activated Reactants and Reactive Intermediates: Powerful Novel Tools in Diversity-Oriented Synthesis; Chapter 21. Scavenger Resins in Solution-Phase CombiChem; Section VIII: Small Molecule and Heterocycle Synthesis; Chapter 22. Cyclative Cleavage Strategies for the Solid- Phase Synthesis of Heterocycles and Natural Products
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Chapter 23. Derivatization Reactions of Heterocyclic Scaffolds on Solid Phase: Tools for the Synthesis of Drug-Like Molecule Libraries
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English
Additional Edition:
ISBN 9780121822729
Additional Edition:
ISBN 0121822729
Language:
English
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