UID:
almafu_9959234389002883
Umfang:
1 online resource (1233 p.)
Ausgabe:
1st ed.
ISBN:
1-281-05057-1
,
9786611050573
,
0-08-048160-4
Inhalt:
Veterinary Toxicology, 2nd edition is a unique single reference that teaches the basic principles of veterinary toxicology and builds upon these principles to offer an essential clinical resource for those practicing in the field. This reference book is thoroughly updated with new chapters and the latest coverage of topics that are essential to research veterinary toxicologists, students, professors, clinicians and environmentalists. Key areas include melamine and cyanuric acid, toxicogenomics, veterinary medical geology, toxic gases, toxicity and safety evaluation of new veterinary pha
Anmerkung:
Description based upon print version of record.
,
Front Cover; Veterinary Toxicology; Copyright Page; Contents; Foreword; Preface; List of Contributors; Part 1 General; Chapter 1 Concepts in veterinary toxicology; INTRODUCTION; HISTORICAL PERSPECTIVE; EVOLUTION OF VETERINARY TOXICOLOGY; A FRAMEWORK FOR ACQUIRING INFORMATION; SOURCES OF INFORMATION; SCHEMATIC EXPERIMENTAL DESIGNS; TOXICOLOGICAL DESCRIPTORS; CONCLUSIONS AND SUMMARY; ACKNOWLEDGMENTS; REFERENCES; Chapter 2 Pharmacokinetics and toxicokinetics: fundamentals and applications in toxicology; INTRODUCTION; FUNDAMENTALS OF XENOBIOTIC DISPOSITION; ABSORPTION
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NON-ORAL ROUTES AND XENOBIOTIC ABSORPTION INHALATION; SPECIES DIFFERENCES IN ABSORPTION; DISTRIBUTION; METABOLISM AND ELIMINATION; CLASSICAL TOXICOKINETIC MODELS; FUNDAMENTAL NON-COMPARTMENTAL TOXICOKINETIC PARAMETERS; BIOAVAILABILITY; CLASSICAL PLASMA/TISSUE TOXICOKINETICS: APPLICATIONS IN DRUG DISCOVERY AND DRUG DEVELOPMENT; APPLICATIONS OF ADME AND TOXICOKINETICS IN DRUG DISCOVERY AND DEVELOPMENT; SPECIES SELECTION FOR TERATOGENICITY; DOSE SELECTION FOR PRECLINICAL EARLY DOSE RANGE-FINDING TOXICITY STUDIES; DOSE SELECTION FOR REPEATED DOSE TOXICITY STUDIES
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CARCINOGENICITY BIOASSAY STUDIES IN RODENTS CONCLUSIONS; REFERENCES; Chapter 3 Physiologically based pharmacokinetic modeling; INTRODUCTION; BACKGROUND; MODEL CONSTRUCTION; PARAMETER ESTIMATION AND IDENTIFIABILITY; MODEL VALIDATION; APPLICATIONS; CONCLUSIONS; REFERENCES; Chapter 4 Toxicological testing: in vivo and in vitro models; INTRODUCTION; IN VIVO MODELS IN TOXICITY TESTING; IN VITRO MODELS OF TOXICITY TESTING; GENERAL SUMMARY AND CONCLUSIONS; REFERENCES; Chapter 5 Epidemiology of animal poisonings; INTRODUCTION; DEMOGRAPHICS; DOGS; CATS; OTHER SPECIES; AGENTS INVOLVED
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SIGNS AND OUTCOMES CONCLUSIONS; REFERENCES; Chapter 6 Chemicals of terrorism; INTRODUCTION; CHLORINE GAS; PHOSGENE; MUSTARD GAS; LEWISITE; PHOSGENE OXIME; CYANIDE AND HYDROGEN CYANIDE; MILITARY NERVE AGENTS; REFERENCES; Chapter 7 Regulatory considerations in veterinary toxicology; INTRODUCTION; SECTION I. FOOD AND DRUG ADMINISTRATION AND THE CENTER FOR VETERINARY MEDICINE; SECTION II. ENVIRONMENTAL PROTECTION AGENCY; SECTION III. US DEPARTMENT OF AGRICULTURE; SECTION IV. DRUG ENFORCEMENT ADMINISTRATION; SECTION V. OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION
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SECTION VI. STATUTES, REGULATIONS, AND GUIDELINES REFERENCES; Chapter 8 Toxicology and the law; INTRODUCTION; REASONS FOR CONDUCTING TOXICOLOGY ANALYSES; JURISDICTION - WHAT ARE THE RULES IN THIS FIGHT AND WHO DECIDES THE WINNER?; STANDARD OF PROOF - HOW SURE DO I NEED TO BE?; EVIDENCE; ADMISSIBILITY OF EXPERT TESTIMONY; SPECIFIC CAUSATION: THE DIFFERENTIAL DIAGNOSIS; APPLICATION OF DAUBERT IN TOXICOLOGY CASES; SOME QUESTIONS TO CONSIDER WHEN USING LABORATORY RESULTS IN A LEGAL CASE; ACKNOWLEDGMENT; REFERENCES; FURTHER READING; Part 2 Organ Toxicity; Chapter 9 Neurotoxicity; INTRODUCTION
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STRUCTURAL TOXICOSES
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English
Weitere Ausg.:
ISBN 0-12-370467-7
Sprache:
Englisch
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