UID:
almafu_9960073418502883
Umfang:
1 online resource (450 p.)
ISBN:
9786612381478
,
9781282381476
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1282381474
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9780080919836
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0080919839
Inhalt:
Systems biology is a critical emerging field that quantifies and annotates the complexity of biological systems in order to construct algorithmic models to predict outcomes from component input. Applications in medicine are revolutionizing our understanding of biological processes and systems.Systems Biomedicine is organized around foundations, computational modeling, network biology, and integrative biology, with the extension of examples from human biology and pharmacology, to focus on the applications of systems approaches to medical problems. An integrative approach to the u
Anmerkung:
Description based upon print version of record.
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Front Cover; Systems Biomedicine: Concepts and Perspectives; Copyright Page; Contents; Overview; SECTION I: FOUNDATIONS OF SYSTEMS BIOLOGY; Chapter 1. Foundations for Systems Biomedicine: An Introduction; INTRODUCTION; EXPERIMENTAL STRATEGIES IN SYSTEMS BIOLOGY; SYSTEMS BIOMEDICINE; CIRCADIAN CYCLES AS A RELEVANT MODEL FOR SYSTEMS BIOMEDICINE; CONCLUSION; References; Chapter 2. Genomic Technologies for Systems Biology; INTRODUCTION; DNA SEQUENCING: HIGH-THROUGHPUT SEQUENCING TECHNOLOGIES; APPLICATIONS OF SEQUENCING IN SYSTEMS BIOLOGY: THE TRANSCRIPTOME AND TRANSCRIPTIONAL REGULATION
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INTERACTION ANALYSIS: TWO-HYBRID SCREENSGENE-BASED PERTURBATION STUDIES: TRANSGENIC KNOCKOUTS; References; Chapter 3. Proteomics Technologies; INTRODUCTION; CELL-BASED PROTEOMICS; PROTEOMICS OF BIOLOGICAL FLUIDS; MICROARRAY-BASED APPROACHES; COMPUTATIONAL ASPECTS OF PROTEOMICS; CONCLUSION; References; Chapter 4. Cellular Regulatory Networks; INTRODUCTION; PART I. TRANSCRIPTIONAL NETWORKS; PART II. PROTEIN PHOSPHORYLATION NETWORKS; ACKNOWLEDGEMENTS; References; Chapter 5. The Interface of MicroRNAs and Transcription Factor Networks; TRANSCRIPTION NETWORK IN CELLULAR SYSTEMS
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MICRORNA BIOGENESIS AND FUNCTIONA STEM CELL MODEL FOR THE TRANSCRIPTIONAL CONTROL OF MIRNAS; LESSONS FROM THE MIRNA REGULATORY LANDSCAPE; ENGINEERING MIRNA NETWORKS; THE ROADMAP TO SYSTEMS BIOLOGY: DECONVOLUTING COMPLEXITIES; CONCLUDING REMARKS; References; Chapter 6. Protein Networks in Integrin-mediated Adhesions; INTRODUCTION; PROBLEM; SOLUTION; CONCLUSION; ACKNOWLEDGEMENTS; References; Chapter 7. Systems Biology and Stem Cell Biology; INTRODUCTION; TRANSCRIPTION NETWORKS; COMPUTATIONAL TOOLS FOR NETWORK CONSTRUCTION AND MODELING
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GENETIC PERTURBATION OF THE ES CELL SYSTEMS TO DISSECT REGULATORY PATHWAYSEPIGENETIC AND CHROMATIN FEATURES OF PLURIPOTENT STEM CELLS; MICRORNAs PROVIDE ANOTHER LAYER OF REGULATORY CONTROL; FORWARDING ENGINEERING OF ES CELL REGULATORY NETWORK; CONCLUDING REMARKS; References; SECTION II: COMPUTATIONAL MODELING IN SYSTEMS BIOLOGY; Chapter 8. Computational Challenges in Systems Biology; INTRODUCTION; DIFFERENT LEVELS OF MODELS OF BIOCHEMICAL SYSTEMS; CHALLENGES IN BUILDING BIOCHEMICAL MODELS; CHALLENGES IN BUILDING MATHEMATICAL MODELS; CHALLENGES IN BUILDING COMPUTATIONAL MODELS
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CASE STUDY: MODELING THE REGULATION OF CALCIUM DYNAMICS IN RAW 264.7 CELLSFUTURE DIRECTIONS AND CONCLUDING REMARKS; ACKNOWLEDGEMENTS; References; Chapter 9. High-level Modeling of Biological Networks; INTRODUCTION; PARTIAL-LEAST-SQUARES MODELING OF SIGNALING NETWORKS; BAYESIAN MODELING OF TRANSCRIPTIONAL NETWORKS; AGENT-BASED MODELING OF CELLULAR NETWORKS; References; Chapter 10. Systems Analysis for Systems Biology; INTRODUCTION; SENSITIVITY ANALYSIS; APPLICATIONS; ACKNOWLEDGEMENTS; References; Chapter 11. The Virtual Cell Project; INTRODUCTION; THE VIRTUAL CELL DATABASE
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MODELING PROCESS IN THE VIRTUAL CELL-BIOMODEL INTERFACE
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English
Weitere Ausg.:
ISBN 9780123725509
Weitere Ausg.:
ISBN 012372550X
Sprache:
Englisch
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