Umfang:
Online-Ressource (XLII, 358. [8] S.)
Ausgabe:
Online-Ausg. 2011 Electronic reproduction; Available via World Wide Web
ISBN:
9780123743138
Serie:
Methods in enzymology 444
Inhalt:
Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently. Understanding how angiogenesis works and how to control it, will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases. Angiogenesis cuts across virtually every discipline. The Angiogenesis Foundation identified angiogenesis as a common denominator in our most serious diseases. Excessive angiogenesis occurs in diseases such as cancer, diabetic blindness, age-related macular degeneration, rheumatoid arthritis, psoriasis, and many other conditions. Insufficient angiogenesis occurs in diseases such as coronary artery disease, stroke, and delayed wound healing. * Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition. * Provides the builder's manual for essential techniques. This is a one-stop shop that eliminates needless searching among untested techniques. * Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics
Anmerkung:
Includes bibliographical references and indexes
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Front Cover; Methods in Enzymology; Copyright Page; Contents; Contributors; Preface; Volumes in Series; Chapter 1: Molecular Mechanism of Type IV Collagen-Derived Endogenous Inhibitors of Angiogenesis; 1. Introduction; 3. Assessing the Role of Type IV Collagen-Derived Endogenous Inhibitor During Angiogenesis; References; Chapter 2: Chick Embryo Chorioallantoic Membrane Models to Quantify Angiogenesis Induced by Inflammatory and Tumor Cells or Purified Effector Molecules; 1. Introduction; 2. Overview of CAM Angiogenesis Models
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3. Assessing the Role of Purified Effector Molecules and Cells in Angiogenesis Using CAM Collagen Onplant Model4. CAM Collagen Onplant Assay Protocol; 5. Validation of CAM Angiogenesis Findings in Collagen Implant Mouse Model; Acknowledgment; References; Chapter 3: The Adenoviral Vector Angiogenesis/Lymphangiogenesis Assay; 1. Introduction; 3. Blood Vessels Induced by Ad-VEGF-A164; Chapter 4: Using the Zebrafish to Study Vessel Formation; 1. Introduction; 4. Conclusion; Chapter 5: Evaluating Vascular Leak in Vivo; 1. Introduction; 2. Mechanisms of Vascular Leak
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3. Consequences of Vascular Leak in Disease4. Models to Study Vascular Leak In Vivo; 5. Concluding Remarks; Chapter 6: Ocular Models of Angiogenesis; 2. Techniques Commonly Used in Ocular Angiogenesis Protocols; 3. Corneal Micropocket Assay; 4. Neonatal Mouse Retinal Developmental Angiogenesis Model; 6. Laser-induced Retinal and Choroidal Neovascularization Models; 9. Cell-based Models and Ocular Angiogenesis; Chapter 7: Mouse Models of Ischemic Angiogenesis and Ischemia-Reperfusion Injury; 1. Introduction; 2. Overview of Methods in Hindlimb I/R Injury
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4. Overview of Methods in Chronic Hindlimb Ischemia6. Conclusion; References; Chapter 8: Noninvasive Imaging of Blood Vessels; 1. Introduction; References; Chapter 9: Intravital Videomicroscopy in Angiogenesis Research; 1. Introduction; 3. Summary; Acknowledgments; Chapter 10: In Vivo Measurements of Blood Flow and Glial Cell Function with Two-Photon Laser-Scanning Microscopy; 1. Introduction; 3. Photoprocesses for Targeted Disruption of Vascular Flow; Acknowledgments; Chapter 11: The Role of Bone Marrow-Derived Cells in Tumor Angiogenesis and Metastatic Progression; 1. The Angiogenic Switch
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3. Bone-Marrow-Derived Cells: Endothelial and Hematopoietic Progenitor Cells4. Bone Marrow-Cell Mobilization in Response to Tumor Factors; 9. Stromal Cells: Carcinoma-Associated Fibroblasts (CAFs); 11. Future Directions; References; Chapter 12: Structure of Microvascular Networks in Genetic Hypertension; 1. Introduction; 2. Methods; 3. Results; 4. Discussion; 5. Summary; References; Chapter 13: Oxygen as a Direct and Indirect Biological Determinant in the Vasculature; 1. Introduction; 3. Physiological, Pathophysiological, and Clinical Settings in Which Oxygen Levels Influence the Vasculature
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Chapter 14: Measuring Intratumoral Microvessel Density
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Electronic reproduction; Available via World Wide Web
In:
Pt. A
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe Angiogenesis ; Pt. A Amsterdam [u.a.] : Elsevier, Acad. Press, 2008 ISBN 9780123743138
Sprache:
Englisch
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