UID:
almafu_9958128249102883
Umfang:
1 online resource (508 p.)
Ausgabe:
1st ed.
ISBN:
9786612169526
,
9781282169524
,
1282169521
,
9780080956978
,
0080956971
Serie:
Methods in enzymology, v. 460
Inhalt:
The understanding of chemokines, the proteins that control the migration of cells, and their receptors, is critical to the study of causes and therapies for a wide range of human diseases and infections, including certain types of cancer, inflammatory diseases, HIV, and malaria. This volume, focusing on chemokines as potential targets for disease intervention, and its companion volume (Methods in Enzymology volume 462, focusing on chemokine structure and function, as well as signaling) provide a comprehensive overview and time-tested protocols in this field, making it an essential refe
Anmerkung:
Description based upon print version of record.
,
Front Cover; Methods In Enzymology: Chemokines, Part A; Copyright Page; Contents; Contributors; Preface; Section 1: Chemokines and Receptors in Disease; Chapter 1: Chapter One Chemokines in Human Breast Tumor Cells: Modifying Their Expression Levels and Determining Their Effects; 1. Introduction; Chapter 2: Chapter 2 CCR5 Pharmacology Methodologies and Associated Applications; 2. CCR5 Signaling Assays and Application to Quantify and Characterize Ligand-Dependent Agonism, Antagonism, and Inverse Ag; References; Chapter 3: Chapter Three CXCR4 and Mobilization of Hematopoietic Precursors
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1. Introduction4. Flow Cytometric Enumeration of Mobilized HSPCs; 8. Concluding Remarks; Chapter 4: Double-Label Nonradioactive; 1. Introduction; Chapter 5: Chapter Five Expression of Chemokines and Chemokine Receptors in Human Colon Cancer; Section II: Chemokine Related Proteins from Pathogens; Chapter 6: Kaposi's Sarcoma Virally Encoded, G-Protein-Coupled Receptor: A Paradigm for Paracrine Transformation; 6. vGPCR-Induced Paracrine Transformation; 9. Activation of Signal-Transducing Protein Kinases and Small GTPases; Acknowledgments
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Chapter 7: Chapter 7 Pharmacological and Biochemical Characterization of Human Cytomegalovirus-Encoded G Protein-Coupled Recept2. Virally Encoded GPCR Engineering; 3. vGPCR Expression, Trafficking, and Radioligand Binding; 7. Conclusions; Chapter 8: Chapter 8 Identification and Characterization of Virus-Encoded Chemokine Binding Proteins; 2. Methods for Studying Chemokine-Binding Proteins; Chapter 9: Chapter Nine The Chemokine-Binding Protein M3 as a Tool to Understand the Chemokine Network; 2. Generation of Transgenic Mice Expressing M3 in Insulin-Producing beta Cells
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3. M3 Expression in Islets of Langerhans Blocks CCL2-, CCL21-, and CXCL13-Induced Migration of Cells to Isle6. Concluding Remarks; Chapter 10: Chapter Ten M-T7: Measuring Chemokine-Modulating Activity; 1. Introduction; 3. Quantifying the Effects of M-T7 In Vitro and Ex Vivo; Section III: Atypical and Novel Chemoattractants and Receptors; Chapter 11: Chapter Eleven Role of the Chemokine Scavenger Receptor D6 in Balancing Inflammation and Immune Activation; Chapter 12: Chapter 12 Structure-Function Dissection of D6, an Atypical Scavenger Receptor; 1. Introduction
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Chapter 13: Chapter Thirteen Modeling Small Molecule-Compound Binding to G-Protein-Coupled Receptors1. Introduction; Chapter 14: Chapter Fourteen Elucidation of Chemerin and Chemokine-Like Receptor-1 Function in Adipocytes by Adenoviral-Mediate; 2. The 3T3-L1 Cell Model for Adipogenesis and Adipocyte Metabolism; Section IV: Chemokine Signaling; Chapter 15: Chapter Fifteen Characterization of Chemokine Receptor CXCR2 Interacting Proteins Using a Proteomics Approach to De; 1. Introduction; 2. Validation of the Interaction of Novel Proteins with CXCR2
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3. Mutational Analysis of Residues at Interactive Interface of CXCR2 and CXCR2-Binding Proteins
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English
Weitere Ausg.:
ISBN 9780123749086
Weitere Ausg.:
ISBN 0123749085
Sprache:
Englisch
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