UID:
almafu_9960073332702883
Umfang:
1 online resource (xvi, 352 pages) :
,
illustrations (some color)
ISBN:
9780128102640
,
0128102640
,
9780124051683
,
0124051685
Serie:
Gale eBooks
Inhalt:
Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise pi
Anmerkung:
Description based upon print version of record.
,
Front Cover; Biological DNA Sensor; Copyright Page; Contents; List of Contributors; Preface; A: The Discovery of dsDNA Immunogenicity and the Definition of DNA Sensing Pathways; 1 Route to Discovering the Immunogenic Properties of DNA from TLR9 to Cytosolic DNA Sensors; Introduction; The Importance of the Innate Immune System; PAMPS and DAMPs; Pathogen Derived Nucleic Acids are Potent Activators of the Innate Immune System; Endosomal-Membrane Bound DNA Sensor - TLR9; Toll-Like Receptors in Innate Immunity; TLR9 and CpG; Cytosolic DNA Sensors
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Signs that TLR9 may not be the only DNA Intracellular SensorDsDNA Utilizes the TBK1-IRF3 Signaling Pathway; Identified Cytosolic DNA Sensors; Z-DNA Binding Protein-1 (ZBP-1); ZBP-1 Died or Dies Hard; Leucine-Rich Repeat (in Flightless I) Interacting Protein-1 (LRRFIP1); DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 41 (DDX41); RNA Polymerase III; PYHIN Family: AIM2 and IFI16; AIM2; AIM2 Regulation by p202; IFI16; DHX36 and DHX9; Ku70; HMGB Proteins; Histone H2B; MRE11; cGAMP as Second Messenger of the DNA Sensing and cGAS as a Cytosolic DNA Sensor; Conclusion; Acknowledgment; References
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2 The PYHIN Family of Molecules and their Functions Sensing dsDNAIntroduction; Members of the Pyhin Family; Structural Basis of DNA Recognition by PYHIN Proteins; Microbial DNA Sensing and Signaling by PYHIN Proteins; AIM2; IFI16; P204; p202 (IFI202) and other PYHIN Proteins; Transcriptional Regulation by PYHIN Proteins; Role of PYHIN Proteins in the Development of Autoimmunity; Regulation of PYHIN Proteins; Conclusions; References; 3 Cytosolic DNA-Sensing and the STING Pathway; Introduction; The Toll-Like Pathway: TLR9 and CpG DNA; The STING Pathway and Intracellular DNA Signaling
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STING and Inflammatory DiseaseOther Sensors of Intracellular DNA; Conclusion; References; 4 Regulation of Intracellular dsDNA-Induced Innate Immune Responses by Autophagy-Related Proteins; Part I. Autophagy-Related Proteins and STING-Dependent IFN Responses; STING Mediates dsDNA-Induced Expression of Type I IFNs; Autophagy-Related Protein Regulates Membrane Trafficking and Induces Autophagosome Formation; Autophagy-Related Proteins Regulate STING-Mediated Expression of Type I IFNs; Part II. Autophagy and STING-Dependent Bactericidal Responses
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Autophagy Functions as a Host Defense System Against Invading MycobacteriaSTING Mediates Autophagy-Dependent Elimination of Invading Mycobacteria; Part III. Autophagy and AIM2-Dependent Inflammatory Responses; Inflammasomes Mediate Inflammatory Innate Immune Responses; Autophagy-Deficiency Enhances Production of Proinflammatory Cytokine IL-1β; Autophagy Limits dsDNA-Induced Activation of AIM2-Inflammasome; Conclusion; References; B: dsDNA and Its Part in Modulating Human Diseases; 5 Host DNA Induced Inflammation and Autoimmune Diseases; Introduction
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The Type I IFN System as the Crux of Autoimmunity
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English
Weitere Ausg.:
ISBN 9780124047327
Weitere Ausg.:
ISBN 0124047327
Weitere Ausg.:
ISBN 9781306087261
Weitere Ausg.:
ISBN 1306087260
Sprache:
Englisch
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