Kooperativer Bibliotheksverbund

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Format: 1 online resource (452 pages)

ISBN: 9780128005842 , 012800584X

Content: "Serotonin: The mediator that spans evolution provides a comprehensive review of the widespread roles for serotonin in respiratory, cardiovascular and thermoregulatory control, and growth and development in early life. This important resource highlights serotonin's role in normal (unstressed) conditions and in response to a variety of physiological stressors. It focuses on new animal models, comparing and contrasting data from mice and rats. It also compares and contrasts physiological effects of brain and blood serotonin systems. Included is new data that suggests the influence of serotonin is in part through the regulation of gene expression--this includes important proteins within the serotonin system itself, as well as proteins in interacting neurotransmitter systems. Finally, it discusses the role of serotonin system dysfunction in a variety of pathophysiological conditions, including sleep apnea, obesity and hypertension; and provides compelling evidence that this dysfunction is involved in Sudden Infant Death Syndrome (SIDS)."--

Note: Front Cover -- Serotonin -- Serotonin: The Mediator That Spans Evolution -- Copyright -- Contents -- Contributors -- Foreword -- 1 - Biophysics of Serotonin -- 1 - Biophysics of Serotonin and the Serotonin1A Receptor: Fluorescence and Dynamics -- 1. SEROTONIN: AN ANCIENT MOLECULE WITH DIVERSE PROPERTIES -- 2. SEROTONIN: A FLUORESCENT NEUROTRANSMITTER -- 3. THE SEROTONIN1A RECEPTOR: A REPRESENTATIVE MEMBER OF SEROTONIN RECEPTOR FAMILY -- 4. RECEPTOR DYNAMICS: THE RELEVANCE OF TIME SCALES -- 5. MEMBRANE LATERAL DYNAMICS OF THE SEROTONIN1A RECEPTOR UTILIZING BLEACH AREA-DEPENDENT FRAP: CONSEQUENCE OF MEMBRANE DOMAINIZATION -- 6. ACTIN CYTOSKELETON-INDUCED CONFINED DYNAMICS OF THE SEROTONIN1A RECEPTOR REVEALED BY ZFCS -- 7. CONCLUSION AND THE ROAD AHEAD -- REFERENCES -- 2 - Serotonin in Plants: Origin, Functions, and Implications -- ABBREVIATIONS -- 1. INTRODUCTION -- 2. EVOLUTION AND OCCURRENCE IN PLANTS -- 3. FUNCTIONS IN PLANTS -- 3.1 PHOTOSYNTHESIS -- 3.2 GROWTH AND MORPHOGENESIS -- 3.3 REPRODUCTION -- 3.4 STRESS -- 3.5 SIGNALING -- 4. SEROTONIN ACROSS OTHER KINGDOMS AND APPLICATIONS TOWARDS PHYTOSEROTONIN RESEARCH -- 4.1 ANIMALIA -- 4.2 FUNGI -- 4.3 PROTOZOA -- 4.4 ARCHAEA -- 4.5 BACTERIA -- 5. CONCLUSION -- REFERENCES -- 2 - Anatomy -- 3 - Serotonergic Neurons in Vertebrate and Invertebrate Model Organisms (Rodents, Zebrafish, Drosophila melanogaster, Aplysia californica, Caenorhabditis elegans) -- 1. INTRODUCTION -- 2. VERTEBRATE MODELS -- 2.1 RATTUS NORVEGICUS AND MUS MUSCULUS -- 2.1.1 Metabolism and Receptors -- 2.1.2 Structure in the Adult Brain. Organization of Cell Bodies and Their Projections -- 2.1.3 Development -- 2.2 DANIO RERIO -- 2.2.1 Metabolism and Receptors -- 2.2.2 Anatomy -- 3. INVERTEBRATES -- 3.1 DROSOPHILA MELANOGASTER -- 3.1.1 Metabolism and Receptors -- 3.1.2 Anatomy -- 3.2 APLYSIA CALIFORNICA. , 3.2.1 Metabolism and Receptors -- 3.2.2 Anatomy -- 3.3 CAENORHABDITIS ELEGANS -- 3.3.1 Metabolism and Receptors -- 3.3.2 Anatomy -- ACKNOWLEDGMENTS -- REFERENCES -- 4 - 5-Hydroxytryptamine in the Endocrine Pancreas -- 1. SEROTONIN (5-HYDROXYTRYPTAMINE) IN THE ISLETS OF LANGERHANS -- 2. 5-HT SYNTHESIS, VESICULAR LOADING, UPTAKE, AND BREAKDOWN IN PANCREATIC β-CELLS -- 3. ISLET HORMONE SECRETION AND 5-HYDROXYTRYPTAMINE -- 4. FUNCTIONAL IMPACT OF SPECIES DIFFERENCES -- REFERENCES -- 5 - Serotonin in Platelets -- ABBREVIATIONS -- 1. INTRODUCTION: A BRIEF HISTORY OF PLATELETS AND SEROTONIN -- 1.1 THE DISCOVERY OF PLATELETS AND THEIR ASSOCIATION WITH SEROTONIN -- 2. THE BIOLOGY OF PLATELETS -- 2.1 MAJOR PLATELET RECEPTORS AND THEIR LIGANDS -- 2.1.1 Glycoprotein 1b-IX-V and von Willebrand Factor -- 2.1.2 Integrin αIIbβ3 and Fibrinogen -- 2.1.3 Glycoprotein VI and Collagen -- 2.2 PLATELET AGONISTS -- 2.2.1 Weak Platelet Agonists-Adenosine Diphosphate and Thromboxane A2 -- 2.2.2 Potent Platelet Agonist-Thrombin -- 2.3 PLATELET STORAGE GRANULES -- 2.3.1 Lysosomes and α-Granules -- 2.3.2 δ-Granules -- 3. SEROTONIN WITHIN THE PLATELET -- 3.1 STORAGE OF SEROTONIN WITHIN THE PLATELET -- 3.1.1 Serotonin Reuptake Transporters and the Uptake of Serotonin in Platelets -- 3.1.2 Signaling Mechanisms Regulating Serotonin Reuptake Transporter Expression -- 3.1.3 Transport of Serotonin Into Platelet Dense Granules -- 3.1.4 Breakdown of Serotonin in the Platelet by Monoamine Oxidase -- 3.2 THE ACTION OF SEROTONIN ON THE PLATELET -- 3.2.1 The 5-HT2A Receptor and the Platelet Response -- 3.2.2 "Serotonylation" of Platelet Proteins -- 3.3 PHYSIOLOGICAL AND PATHOLOGICAL CONSEQUENCES OF SEROTONIN IN PLATELETS, HEMOSTASIS, AND THROMBOSIS -- 3.3.1 A Historical Perspective on the Role of Serotonin in Hemostasis and Thrombosis. , 3.3.2 A Current Perspective-The Role of Serotonin in Hemostasis and Thrombosis -- 4. CLINICAL MANIFESTATIONS OF ALTERED PLATELET SEROTONIN -- 4.1 ELEVATED SEROTONIN AND PLATELET HYPERACTIVITY -- 4.2 SEROTONIN IN HYPERTENSION -- 4.3 SELECTIVE SEROTONIN REUPTAKE INHIBITORS AND AN INCREASED RISK OF BLEEDING -- 4.4 TARGETING OF THE 5-HT2A SEROTONIN RECEPTOR SUBTYPE FOR CARDIOVASCULAR INDICATIONS -- 5. CONCLUSION -- REFERENCES -- 6 - Anatomy of the Serotonin Transporter -- 1. INTRODUCTION -- 1.1 HISTORICAL BACKGROUND -- 1.2 TOPOLOGICAL STRUCTURE -- 1.3 FUNCTION -- 2. ANATOMICAL DISTRIBUTION OF THE 5-HTT IN THE CENTRAL NERVOUS SYSTEM -- 2.1 5-HTT EXPRESSION IN RAPHE SEROTONIN NEURONS -- 2.1.1 Superior Raphe Nuclei -- 2.1.1.1 Dorsal Raphe Nucleus -- 2.1.1.2 Median Raphe Nucleus -- 2.1.1.3 Supralemniscal Nucleus -- 2.1.2 Inferior Raphe Nuclei -- 2.1.2.1 Nucleus Raphe Obscurus -- 2.1.2.2 Nucleus Raphe Pallidus -- 2.1.2.3 Nucleus Raphe Magnus -- 2.1.2.4 Ventral Lateral Medulla -- 2.2 DISTRIBUTION OF THE 5-HTT-BINDING SITES -- 2.3 SUBCELLULAR LOCALIZATION OF THE 5-HTT BY ELECTRON MICROSCOPY -- 3. EXPRESSION AND LOCALIZATION OF THE 5-HTT IN NONSEROTONIN NEURONS OR GLIA -- 4. ANATOMICAL DISTRIBUTION OF THE 5-HTT IN THE PERIPHERAL NERVOUS SYSTEM -- 5. ABSENCE OF SEROTONIN TRANSPORTER IN A SUBSET OF SEROTONIN AXONS -- 6. CONCLUSION -- REFERENCES -- 3 - Physiology in the Periphery -- 7 - Cellular Regulation of Peripheral Serotonin -- 1. INTRODUCTION -- 2. SECRETORY MECHANISMS OF 5-HYDROXYTRYPTAMINE RELEASE FROM ENTEROCHROMAFFIN CELLS -- 3. NEUROCHEMICAL AND MECHANICAL STIMULATION OF ENTEROCHROMAFFIN CELLS -- 3.1 NEUROCHEMICAL STIMULI -- 3.2 MECHANICAL STIMULI -- 4. ENTEROCHROMAFFIN CELLS ARE NUTRIENT SENSORS -- 5. INTESTINAL BACTERIA MEDIATE HOST PHYSIOLOGY THROUGH ENTEROCHROMAFFIN CELL 5-HYDROXYTRYPTAMINE. , 6. GASTROINTESTINAL HORMONAL CROSS TALK WITH ENTEROCHROMAFFIN CELLS -- 7. CONCLUDING REMARKS -- REFERENCES -- 8 - Role of 5-Hydroxytryptamine in the Control of Gut Motility -- 1. INTRODUCTION -- 2. RELEASE OF 5-HYDROXYTRYPTAMINE FROM THE MUCOSA -- 3. REAL-TIME RECORDINGS OF 5-HYDROXYTRYPTAMINE RELEASE DURING INTESTINAL MOTOR ACTIVITIES -- 4. MUCOSAL COMPRESSION AND ACTIVATION OF PERISTALSIS -- 5. ENTEROCHROMAFFIN CELLS RELEASE MANY SUBSTANCES -- 6. SEROTONIN-A NEUROTRANSMITTER IN THE ENTERIC NERVOUS SYSTEM? -- 7. 5-HT ANTAGONISTS CAN BLOCK PERISTALSIS IN PREPARATIONS DEPLETED OF ALL 5-HT -- 8. CONCLUDING REMARKS -- REFERENCES -- 9 - Phenotype of Mice Lacking Tryptophan Hydroxylase 1 -- 1. INTRODUCTION -- 2. PLATELETS, IMMUNE SYSTEM, AND INFLAMMATION -- 3. ERYTHROPOIETIC SYSTEM -- 4. LIVER -- 5. PANCREAS AND FAT -- 6. EMBRYOGENESIS AND HEART -- 7. LUNG -- 8. MAMMARY GLAND -- 9. GUT -- 10. BONE -- 11. CONCLUSIONS -- REFERENCES -- 10 - Serotonin and the Immune System -- 1. INTRODUCTION -- 1.1 HOW DO IMMUNE CELLS ENCOUNTER SEROTONIN? -- 1.2 SEROTONIN AND HEMATOPOIESIS -- 1.3 SEROTONIN AND THE IMMUNE TOLERANCE -- 2. SEROTONIN AND THE INNATE IMMUNE RESPONSE -- 2.1 SEROTONIN AND NEUTROPHILS -- 2.2 SEROTONIN AND MONOCYTES -- 2.2.1 Serotonin and Monocyte-to-Macrophage Differentiation -- 2.2.2 Serotonin and Microglia -- 2.3 SEROTONIN AND DENDRITIC CELLS -- 2.4 SEROTONIN AND EOSINOPHILS -- 2.5 SEROTONIN AND MAST CELLS -- 3. SEROTONIN AND ADAPTIVE IMMUNITY -- 3.1 SEROTONIN AND T LYMPHOCYTES -- 3.2 SEROTONIN AND B LYMPHOCYTES -- 4. CONCLUDING REMARKS -- REFERENCES -- 11 - Serotonin and Adipocyte Function -- 1. ADIPOSE TISSUE -- 2. IMPACT OF SEROTONIN ON METABOLIC REGULATION -- 3. ADIPOSE TISSUE-SPECIFIC EFFECTS OF 5-HYDROXYTRYPTAMINE -- 4. IMPACT OF 5-HYDROXYTRYPTAMINE ON ADIPOKINE SECRETION. , 5. 5-HYDROXYTRYPTAMINE-MEDIATED EFFECTS ON PREADIPOCYTE DIFFERENTIATION -- REFERENCES -- 12 - Serotonin and Cardiovascular Diseases -- 1. INTRODUCTION -- 2. SEROTONIN IN CARDIAC MORPHOGENESIS -- 2.1 EXPRESSION AND FUNCTION 5-HT2A AND 5-HT2B RECEPTORS IN EMBRYONIC HEART -- 2.2 EXPRESSION AND FUNCTION OF 5-HT4 IN EMBRYONIC HEART -- 2.3 EXPRESSION AND FUNCTION OF SEROTONIN TRANSPORTER IN EMBRYONIC HEART -- 2.4 MATERNAL ORIGIN OF SEROTONIN -- 3. ADULT ORIGIN OF SEROTONIN -- 4. ROLE OF 5-HT2B RECEPTORS IN POSTNATAL MATURATION AND CARDIOVASCULAR DEVELOPMENT -- 5. SEROTONIN IN ADULT HEART -- 5.1 SEROTONIN ORIGIN IN ADULT HEART -- 5.2 DEPRESSION AND CARDIOVASCULAR RISK -- 6. SEROTONIN IN CARCINOID HEART -- 6.1 ECHOCARDIOGRAPHIC IDENTIFICATION OF CARCINOID HEART LESIONS -- 6.2 ANATOMOPATHOLOGIC AND HISTOLOGIC PROPERTIES OF CARCINOID HEART LESIONS -- 6.3 IMPLICATION OF SEROTONIN IN CARCINOID HEART LESIONS -- 6.4 PHARMACOLOGICAL MECHANISMS IN CARCINOID HEART -- 6.4.1 5-HT2 Receptor Expression -- 6.4.2 5-HT2 Receptor Ligand -- 6.4.3 Valvulopathy, a Reinitialization of Embryonic Valve Development? -- 6.4.4 Valvulopathy and Bone Marrow Mobilization of Endothelial Progenitors -- 7. SEROTONIN IN CARDIAC HYPERTROPHY AND FAILURE -- 7.1 SEROTONIN AND ITS RECEPTORS IN CARDIAC REMODELING -- 7.2 SEROTONIN AND ITS RECEPTORS IN CARDIAC HEMODYNAMICS AND FAILURE -- 7.3 ATRIAL FIBRILLATION AND 5-HT4 RECEPTORS -- 8. VASCULAR RESPONSES TO SEROTONIN -- 8.1 HYPERTENSION -- 8.2 CORONAROPATHY AND ISCHEMIC PRECONDITIONING -- 8.3 MIGRAINE -- 8.4 PULMONARY ARTERIAL HYPERTENSION -- REFERENCES -- 13 - Involvement of 5-HT in Cardiovascular Afferent Modulation of Brainstem Circuits Involved in Blood Pressure Maintenance -- ABBREVIATIONS -- 1. INTRODUCTION -- 2. NUCLEUS TRACTUS SOLITARII -- 2.1 5-HT1 RECEPTORS -- 2.2 5-HT1B/1D RECEPTORS -- 2.3 5-HT2 RECEPTORS -- 2.4 5-HT3 RECEPTORS. , 2.5 5-HT4 RECEPTORS.

Additional Edition: ISBN 9780128000502

Additional Edition: ISBN 0128000503

Language: English