UID:
almafu_9960073574802883
Umfang:
1 online resource (208 p.)
ISBN:
9780128008324
,
0128008326
Inhalt:
Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams. Focused approach to review those organic chemistry concepts that are most important for medicinal chemistry practice and understanding Accessible content to refresh the reader's knowledge of bonding, structure, functional groups, stereochemistry, and more Appropriate level of coverage for students in organic chemistry, medicinal chemistry, and related areas; individuals seeking content review for graduate and medical courses and exams; pharmaceutical patent attorneys; and chemists and scientists requiring a review of pertinent material.
Anmerkung:
Bibliographic Level Mode of Issuance: Monograph
,
Front Cover -- Organic Chemistry Concepts and Applications for Medicinal Chemistry -- Copyright -- DEDICATION -- CONTENTS -- PREFACE -- Chapter 1 - Bonding in Organic Compounds -- ATOMIC ORBITALS -- HYBRID ORBITALS -- RESONANCE -- AROMATICITY -- REFERENCE -- Chapter 2 - The Three-Dimensional Structure of Organic Compounds -- ISOMERS -- STEREOISOMERISM AT SATURATED CENTERS -- PROCHIRALITY -- STEREOISOMERISM AT UNSATURATED CENTERS -- CONFORMATIONS -- REFERENCE -- Chapter 3 - Functional Groups -- COMMON FUNCTIONAL GROUPS -- THE ELECTRONIC EFFECTS OF FUNCTIONAL GROUPS -- REFERENCES -- CHAPTER 4 - ACIDS AND BASES* -- IONIZATION -- ESTIMATING ACID/BASE STRENGTH -- LEWIS ACIDS AND BASES -- Chapter 5 - Partition Coefficients -- WHAT IS A PARTITION COEFFICIENT? -- EFFECT OF STRUCTURE ON PARTITION COEFFICIENTS -- REFERENCE -- Chapter 6 - The Nomenclature of Cyclic and Polycyclic Compounds -- COMMON HETEROCYCLES -- FUSED-RING SYSTEMS -- SUBSTITUENTS AND SATURATION -- BRIDGED RINGS -- SPIRO RINGS -- SPECIAL CLASSES OF COMPOUNDS -- Chapter 7 - Drug Metabolism -- PHASE I: OXIDATIVE PROCESSES -- PHASE I: REDUCTIONS -- PHASE I: HYDROLYSIS -- PHASE II: CONJUGATION -- MISCELLANEOUS PHASE II PROCESSES -- REFERENCES -- INDEX.
,
English
Weitere Ausg.:
ISBN 9780128007396
Weitere Ausg.:
ISBN 0128007397
Weitere Ausg.:
ISBN 9781306642385
Weitere Ausg.:
ISBN 1306642388
Sprache:
Englisch
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