Kooperativer Bibliotheksverbund

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Umfang: 1 online resource (376 p.)

ISBN: 9780128016763 , 0128016760

Inhalt: Early Vascular Aging (EVA): New Directions in Cardiovascular Protection brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV). The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. Information provided is accompanied by online access to a supplemental website with video clips of anatomic speci

Anmerkung: Description based upon print version of record. , Front Cover; Early Vascular Aging (EVA); Copyright Page; Contents; List of Contributors; Preface; 1 Historical Aspects and Biology of Aging; Evolutionary Traits, Genes, and the Environment Influencing Aging; Changes During the Twentieth Century in Life Expectancy; Early Life Programming Effects; Vascular Aging in Perspective; New Models and Interventions to Influence Aging; Acknowledgment; References; 2 Cellular and Molecular Determinants of Arterial Aging; Introduction; Cytoskeletal and Contractile Proteins in the Aging Arterial Wall; Cytoskeletal Proteins; Contractile Proteins , Cellular Matrix Structure in the Aging Arterial WallProinflammatory Molecular, Cellular, and Vascular Events in the Aging Arterial Wall; The Renin-Angiotensin-Aldosterone System; Proteinases; Matrix Metalloproteinases; Calpain-1; Transforming Growth Factor-β1; Monocyte Chemoattractant Protein-1; Reactive Oxygen Species and NO Bioavailability; MFG-E8, Fibronectin, and Integrin Receptors; MFG-E8 and Its Fragment Medin; Fibronectin; Transcription Factors; Cytoskeletal Serum Response Transcription Factor; Proinflammatory Transcription Factors Ets-1 and NF-κB; Anti-Inflammatory Molecule SIRT1 , ConclusionAcknowledgment; References; 3 Aging Population: Challenges and Opportunities in a Life Course Perspective; Aging Populations-Between Decreasing Mortality and Improved Health; Living Longer, but with More Chronic Diseases; From Healthcare of Older Subjects to Life Course Approach; Strategies for Healthy Aging; References; 4 Population-Based Studies: Milestones on the Epidemiological Timeline; Introduction; Proven Prognostic Power in High-Risk Subpopulations; Proven Prognostic Power in the General Population; Beyond Curve Divergence; Data Harmonization , Quo Vadis: More Depth and Breadth of Phenotyping, More Comprehensive Populations, Longer Event HorizonsMore Depth and Breadth of Phenotyping: Wave Reflection; More Depth and Breadth of Phenotyping: Time-Varying Phenomena; More Comprehensive Populations: Studying the Early Impact of Cardiovascular Risk Factors; More Comprehensive Populations: Early Vascular Aging and Stroke-Prone Populations; Longer Event Horizons; References; 5 Lessons from the Amsterdam Growth and Health Longitudinal Study; AGAHLS-The Cohort Profile; Study Design and Population , The Introduction of Large Artery Properties Measures-Rationale and MethodsDefinition of Vascular Aging Phenotypes; Early Determinants of Arterial Stiffness-A Life Course Approach; Cumulative Burden and Trajectories of Biological RFs-The Critical Role of BP and (Central) Fatness; Blood Pressure; Total and Central Fatness; Blood Lipids and Physical Fitness; Cumulative Burden and Trajectories of Lifestyle RFs-The Preventive Role of Lifelong Lifestyles; Dietary Intake; Habitual Physical Activity; Sedentary Behavior; Additional Studies; Conclusions; Acknowledgment; References , 6 Cardiovascular Aging: Perspectives from the Baltimore Longitudinal Study of Aging (BLSA) , English

Weitere Ausg.: ISBN 9780128013878

Weitere Ausg.: ISBN 0128013877

Sprache: Englisch