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Umfang: 1 online resource (468 pages) : , color illustrations, tables.

ISBN: 9780128026090 , 012802609X

Serie: Translational Epigenetics Series

Anmerkung: Front Cover -- CHROMATIN SIGNALING AND DISEASES -- Translational Epigenetics Series -- CHROMATIN SIGNALING AND DISEASES -- Copyright -- Contents -- List of Contributors -- Bases of Chromatin Signaling and Their Impact on Diseases Pathogenesis -- CHROMATIN STRUCTURE AND DYNAMICS -- GENE EXPRESSION -- CHROMATIN SIGNALING -- ROLE OF CHROMATIN SIGNALING IN HUMAN PATHOLOGIES -- BOOK OPENING REMARKS -- References -- I - HISTONE MARK WRITERS -- 1 - Histone Acetyltransferases, Key Writers of the Epigenetic Language -- INTRODUCTION -- FUNCTIONAL AND MECHANISTIC IMPACT OF HISTONE ACETYLATION -- IDENTIFICATION OF THE FIRST HISTONE ACETYLTRANSFERASES, A HISTORICAL PERSPECTIVE -- Identification of a Histone Deposition-Related Histone Acetyltransferase -- Identification of Transcription-Related Histone Acetyltransferases -- YEAST HISTONE ACETYLTRANSFERASES BELONG TO THREE DIFFERENT FAMILIES -- The GNAT Family of Histone Acetyltransferases -- The MYST Family of Histone Acetyltransferases -- Rtt109 as a Unique Fungal-Specific Histone Acetyltransferase -- General Principles About Yeast Histone Acetyltransferases -- THREE FAMILIES OF METAZOAN HISTONE ACETYLTRANSFERASES AND THEIR ROLES IN ANIMAL DEVELOPMENT -- The GNAT Family of Histone Acetyltransferases and Their Roles in Animal Development -- p300, CBP, and Their Functions in Different Developmental Processes -- MYST Proteins, Multisubunit Complexes, and Functions in Animal Development -- ROLE OF HISTONE ACETYLTRANSFERASES IN THE PATHOGENESIS OF HUMAN DISEASES -- GNATs in Cancer, Neurodegenerative Disorders, and Genetic Diseases -- p300 and CBP in Rubinstein-Taybi Syndrome and Different Types of Cancer -- MYST Proteins in Cancer and Developmental Disorders -- CONCLUSIONS AND FUTURE DIRECTIONS -- List of Acronyms and Abbreviations -- Glossary -- References -- 2 - Impacts of Histone Lysine Methylation on Chromatin. , CHROMATIN REGULATION AND POSTTRANSLATIONAL MODIFICATIONS -- Modification of Lysine Residues on Histones -- Lysine Methylation of Histones -- Identification of Histone Lysine Methylation -- HISTONE LYSINE METHYLTRANSFERASES -- SET Domain Lysine Methyltransferases -- Seven β-strand Lysine Methyltransferases -- HISTONE H3K4 METHYLATION (FIG. 2.1) -- Distribution and Recognition of H3K4 Methylation -- Deconstructing a COMPASS -- Regulation of KMT2 Enzymatic Activity by the WRAD Complex -- KMT2 Enzymes and Leukemia -- HISTONE H3K9 METHYLATION (FIG. 2.1) -- H3K9 Methyltransferases -- Distribution of Methylated H3K9 -- Establishment of Pericentromeric Heterochromatin and H3K9 Methylation -- Transcriptional Regulation by G9a/GLP -- Interplay Between H3K9 and DNA Methylation -- Links Between Histone H3K9 Methylation and Diseases -- HISTONE H3K27 METHYLATION (FIG. 2.1) -- Histone H3K27 Methyltransferases -- Distribution of Methylated H3K27 Across the Chromatin Landscape -- EZH2 and the PRC2 Complex -- EZH2 in Gene Silencing -- EZH2 in Chromosome Xi Silencing -- H3K27me Alterations in Cancers -- HISTONE H3K36 METHYLATION -- Genomic Landscape of H3K36 Methylation -- H3K36 methyltransferases (Fig. 2.1) -- The Role of H3K36 Methylation During Transcription and DNA Damage -- Mechanistic Insights Into H3K36 Methylation -- Methylation of H3K36 and NSD Methyltransferases in Sotos and Wolf-Hirschhorn Syndromes and Cancers -- HISTONE H3K79 METHYLATION (FIG. 2.1) -- Distribution of Mono-, Di-, and Trimethylated H3K79 Across the Chromatin Landscape -- Crosstalk Between H3K79 Methylation and the Silent Information Regulator Complex -- Histone H2B Ubiquitination Links Dot1 Activity to Transcription -- Dot1 KMT Activities During the DNA Damage Response -- The Role of Dot1 Methyltransferase in Acute Myeloid Leukemias. , Mechanistic Determinants Controlling H3K79 Recognition by Dot1 -- HISTONE H4K20 METHYLATION -- H4K20 Methyltransferases (Fig. 2.1) -- Distribution of H4K20me -- MONOMETHYLATION OF H4K20 PROMOTES MITOTIC CHROMATIN CONDENSATION AND DNA REPLICATION -- Importance of SET8 Catalytic Activity in the DNA Damage Response -- Transcriptional Repression by H4K20 Monomethylation -- Di- and Trimethylation of H4K20 by SUV420H1/H2 -- H4K20 Methylation and Diseases -- EMERGING ROLES OF NON-CANONICAL HISTONE LYSINE METHYLATION -- CONCLUSIONS -- List of Acronyms and Abbreviations -- References -- 3 - The Role of Histone Mark Writers in Chromatin Signaling: Protein Arginine Methyltransferases -- INTRODUCTION -- GENERAL PROPERTIES OF PROTEIN ARGININE METHYLTRANSFERASES -- Characteristics of an Arginine Residue -- Classification of Protein Arginine Methyltransferases -- Properties of Protein Arginine Methyltransferases -- Readers of Arginine Methylation -- Regulation of Protein Arginine Methyltransferases -- MAMMALIAN PROTEIN ARGININE METHYLTRANSFERASES AND THEIR EFFECTS ON GENE EXPRESSION -- Protein Arginine Methyltransferase 1 -- Protein Arginine Methyltransferase 2 -- Protein Arginine Methyltransferases 4/Co-activator-associated Arginine Methyltransferase 1 -- Protein Arginine Methyltransferase 5 -- Protein Arginine Methyltransferase 6 -- Protein Arginine Methyltransferase 7 -- CONCLUSIONS -- List of Acronyms and Abbreviations -- Glossary -- Acknowledgments -- References -- 4 - Histone Kinases and Phosphatases -- INTRODUCTION -- HISTONE PHOSPHORYLATION: BASIC CONCEPTS -- HISTONE KINASES IN NUCLEOSOME PACKING AND ASSEMBLY -- HISTONE KINASES AND CELL DIVISION -- Displacement -- Chromosome Condensation -- Landmarks -- Building the Kinetochore -- HISTONE KINASES IN DNA REPAIR AND REPLICATION -- HISTONE KINASES AND PROGRAMMED CELL DEATH -- HISTONE KINASES AND TRANSCRIPTION. , H3S10 and H3S28 Kinases -- How Do H3S10ph and H3S28ph Regulate Transcription? -- Phosphorylation of Other H3 Residues -- Phosphorylation of H2B and H4 -- HISTONE PHOSPHATASES -- CONCLUSIONS -- List of Acronyms and Abbreviations -- Glossary -- References -- II - HISTONE MARK READERS -- 5 - The Bromodomain as an Acetyl-Lysine Reader Domain -- LYSINE ACETYLATION AND THE BROMODOMAIN -- DISCOVERY OF THE BROMODOMAIN AS AN ACETYL-LYSINE RECOGNITION MODULE -- BIOLOGICAL FUNCTIONS OF BROMODOMAIN PROTEINS -- Interaction With Other Chromatin-Associated Modules -- Bromodomain Proteins and Lysine-Mediated Interactions in Gene Transcription -- BROMODOMAIN PROTEINS IN HUMAN DISEASE PATHWAYS -- SMALL MOLECULAR INHIBITORS OF BROMODOMAINS -- CONCLUSION -- List of Acronyms and Abbreviations -- Acknowledgments -- References -- 6 - Chromo Domain Proteins -- INTRODUCTION -- THE CHROMO DOMAIN STRUCTURE -- VARIETIES OF CHROMO DOMAINS -- HP1 Family Proteins -- Polycomb Family Proteins -- Chromo Domain Y Chromosome Family -- Chromo Methyltransferases -- Chromo Helicases -- Chromo Acetyltransferases -- CHROMO SHADOW DOMAIN -- NUCLEIC ACID-BINDING CHROMO DOMAINS -- POSTTRANSLATIONAL MODIFICATIONS AND CHROMO DOMAIN TRANSACTIONS -- Posttranslational Modifications of Chromo Domain Proteins -- Histone Phosphorylation and Chromo Domain Binding -- TARGETING CHROMO DOMAINS FOR THERAPEUTICS -- CHROMO DOMAIN ASSOCIATION WITH HUMAN DISEASE -- Evidence for a Role of Chromo Domain Ligands and Their Writers in Cancer Biology -- Impact of Chromo Domain Proteinsin Carcinogenesis -- CONCLUSION -- List of Acronyms and Abbreviations -- Acknowledgments -- References -- 7 - The Role of PHD Fingers in Chromatin Signaling: Mechanisms and Functional Consequences of the Recognition of Hi ... -- INTRODUCTION -- THE HISTORY OF THE PLANT HOMEODOMAIN FINGER -- THE STRUCTURAL BASIS OF HISTONE RECOGNITION. , Specific Recognition of H3K4me3 -- Specific Recognition of H3K4me0 -- Specific Recognition of H3K9me3 -- Specific Recognition of H3K14ac -- THE MECHANISM OF PLANT HOMEODOMAIN FINGERS IN THE COMBINATORIAL READOUT OF PATTERNS OF HISTONE POST-TRANSLATIONAL MODIFICATIONS -- Methods for Screening Histone Post-Translational Modification Recognition and Cross-Talk -- Histone Post-Translational Modification Cross-Talk Mediated by a Single Plant Homeodomain Finger -- Plant Homeodomain Fingers in Multivalent Histone Binding -- In Cis Multivalent Interactions -- In Trans Multivalent Interactions -- NON-HISTONE TARGETS -- Non-Histone Protein Targets of Plant Homeodomain Fingers -- Nucleic Acids, Phosphoinositides, and Unknown Targets of Plant Homeodomain Fingers -- UNDERSTANDING THE ROLE OF THE PLANT HOMEODOMAIN FINGER IN THE FUNCTION OF ITS HOST PROTEIN -- Targeting and Retention at Chromatin -- Regulation of Enzymatic Activity -- PLANT HOMEODOMAIN FINGERS IN DISEASE -- Plant Homeodomain Fingers in Cancer -- Plant Homeodomain Fingers in Developmental and Neurological Disorders -- Plant Homeodomain Fingers in Immunological Disorders -- The Potential of Plant Homeodomain Fingers as a Drug Target -- CONCLUSION -- References -- 8 - Tudor Domains as Methyl-Lysine and Methyl-Arginine Readers -- INTRODUCTION -- THE AROMATIC CAGE: MOLECULAR BASIS OF METHYL-LYSINE AND METHYL-ARGININE RECOGNITION -- TUDOR DOMAINS INTERACTING WITH METHYLATED LYSINE-CONTAINING PEPTIDES -- Single Tudor Domain as Functional Unit for Recognition of Lysine Methylation -- Single Tudor2 Domain of PHF20 -- Single Tudor Domains of PHF1 and PHF19 -- Tandem Tudor Domains as Functional Unit for Recognition of Lysine Methylation -- Tandem Tudor Domains of 53BP1 -- Tandem Tudor Domains of SGF29 -- Tandem Tudor Domains of UHRF1 -- Tandem Tudor Domains of SHH1 -- Tandem Tudor Domains of Spindlin1. , Hybrid Tudor Domains as Functional Unit for Recognition of Lysine Methylation.

Weitere Ausg.: ISBN 9780128023891

Weitere Ausg.: ISBN 0128023899

Sprache: Englisch