UID:
almahu_9949984548902882
Umfang:
1 online resource (553 p.)
Ausgabe:
1st ed.
ISBN:
9781784023805
,
1784023809
,
9781283740388
,
1283740389
,
9780123859457
,
012385945X
Inhalt:
This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biolo
Anmerkung:
Description based upon print version of record.
,
Front Cover; Handbook of Systems Biology: Concepts and Insights; Copyright; Contents; List of Contributors; Preface; Reviewers; Section I - Components of Biological Systems; Chapter 1 - Proteomic Analysis of Cellular Systems; INTRODUCTION; MS-BASED PROTEOMICS WORKFLOW; COMPUTATIONAL PROTEOMICS; DEEP EXPRESSION PROTEOMICS; INTERACTION PROTEOMICS; LARGE-SCALE DETERMINATION OF POST-TRANSLATIONAL MODIFICATIONS; OUTLOOK AND FUTURE CHALLENGES; REFERENCES; Chapter 2 - The Coding and the Non-coding Transcriptome; INTRODUCTION; THE PATHWAY FROM DNA TO PROTEIN SEQUENCES
,
METHODS TO DETERMINE THE REFERENCE TRANSCRIPTOMETHE HUMAN TRANSCRIPTOME; CONCLUSIONS AND FUTURE CHALLENGES; REFERENCES; Section II - Network Properties of Biological Systems; Chapter3 - Interactome Networks; INTRODUCTION; TOWARDS A REFERENCE PROTEIN-PROTEIN INTERACTOME MAP; DRAWING INFERENCES FROM INTERACTOME NETWORKS; TOWARDS DYNAMIC INTERACTOMES; CONCLUDING REMARKS; ACKNOWLEDGEMENTS; REFERENCES; Chapter4 - Gene Regulatory Networks; CELLS ARE COMPUTERS; GENE REGULATION; TRANSCRIPTION; GENE REGULATORY NETWORKS (GRNS); FUTURE CHALLENGES; ACKNOWLEDGEMENTS; REFERENCES
,
Chapter 5 - Analyzing the Structure, Function and Information Flow in Signaling Networks using Quantitative Cellular SignaturesTHE CONCEPT OF LINEAR CASSETTES AND MODULARITY IN SIGNAL TRANSDUCTION; GENETIC DISSECTION OF SIGNAL TRANSDUCTION PATHWAYS; SYSTEMS APPROACHES TO IDENTIFY THE 'PARTS' OF CELLULAR SIGNALING NETWORKS; QUANTITATIVE RNAI SIGNATURES OR PHENOPRINTS TO INFER CONTEXT DEPENDENT INFORMATION FLOW THROUGH CELLULAR SIGNALING NETWORKS; CONCLUDING REMARKS; REFERENCES; Chapter 6 - Genetic Networks; INTRODUCTION; DEFINING GENETIC INTERACTIONS
,
EXPERIMENTAL APPROACHES TO MAP GENETIC INTERACTION NETWORKS IN YEASTEXPLORING GENETIC INTERACTION NETWORKS; INTEGRATING GENETIC INTERACTIONS WITH OTHER BIOLOGICAL NETWORKS; MAPPING GENETIC INTERACTIONS IN OTHER ORGANISMS; GENETIC NETWORK CONSERVATION; EXPANDING GENETIC NETWORKS: MUTANT ALLELES, CONDITIONS AND PHENOTYPES; GENETIC INTERACTIONS AND GENOME-WIDE ASSOCIATION STUDIES; ACKNOWLEDGEMENTS; REFERENCES; Chapter 7 - The Spatial Architecture of Chromosomes; INTRODUCTION; THE BASIC MATERIAL: THE CHROMATIN FIBER; THE POLYMER PHYSICS OF CHROMOSOMES
,
NUCLEAR CONFINEMENT AND FORMATION OF CHROMOSOME TERRITORIESANCHORING OF THE GENOME TO FIXED SCAFFOLDS; THE INTERNAL ORGANIZATION OF CHROMOSOMES: LONG-RANGE INTERACTIONS ALONG AND BETWEEN CHROMOSOMES; A STOCHASTIC INTERACTION-DRIVEN MODEL FOR GENOME FOLDING AND NUCLEAR ORGANIZATION; FUTURE CHALLENGES; REFERENCES; Chapter 8 - Chemogenomic Profiling: Understanding the Cellular Response to Drug; IMPACT OF THE HUMAN GENOME PROJECT ON HEALTHCARE AND BIOLOGY; IMPACT OF GENOMICS: SHIFTING THE PERCEPTIONS OF DRUG AND CELLULAR BEHAVIOR; CHEMOGENOMICS; HIPHOP; CONCLUSIONS AND FUTURE CHALLENGES
,
REFERENCES
,
English
Weitere Ausg.:
ISBN 9780128100462
Weitere Ausg.:
ISBN 012810046X
Weitere Ausg.:
ISBN 9780123859440
Weitere Ausg.:
ISBN 0123859441
Sprache:
Englisch
Bookmarklink
