UID:
edoccha_9961047029102883
Format:
1 online resource (319 pages)
Edition:
1st ed.
ISBN:
0-12-813694-4
,
0-12-813693-6
Note:
Front Cover -- Neurobiology of Abnormal Emotion and Motivated Behaviors -- Copyright Page -- Contents -- List of Contributors -- Introduction Emotion and Motivated Behaviors: Integrating Animal and Human Neurobiology Research -- Section 1: Emotion-Related Impulsivity Across Disorders and Species -- Section 2: Impulsivity and Stress in Eating Disorders -- Section 3: Interaction of Stress and Drug-Seeking -- Section 4: Learning to Inhibit the Fear Response -- Section 5: Abnormal Emotional Reactivity Versus Regulation Across Disorders -- I. Emotion-Related Impulsivity Across Disorders and Species -- 1 Using Preclinical Models to Understand the Neural Basis of Negative Urgency -- Introduction -- Current Models of Negative Urgency -- Human Models -- Animal Models -- Neurobiological Mechanisms of Negative Urgency -- Future Directions -- Highlights -- Acknowledgment -- References -- Further Reading -- 2 Emotion-Related Impulsivity and the Mood Disorders -- Introduction -- Measures of Emotion-Related Impulsivity -- Initial Validation and Links to Psychopathology -- Toward a Model of Emotion-Related Impulsivity in Mood Disorders -- Depression -- Bipolar Disorder -- Suicidality and Self-Harm -- Summary -- Possible Mechanisms: The Role of Response Inhibition -- Unanswered Questions -- Future Directions -- Highlights -- References -- Further Reading -- II. Impulsivity and Stress in Eating Disorders -- 3 Impulsivity, Stress Reactivity, and Eating Disorders -- Introduction -- Current Models -- Impulsivity and Binge Eating -- Negative Urgency and Binge Eating -- Mechanisms -- Negative Urgency and Expectancies: Expectancies as a Cognitive Representation of Prepotent Response -- Neurobiological Underpinnings of Negative Urgency -- Future Directions -- Highlights -- References -- Further Reading.
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4 The Genetic Diathesis of Eating Disorders: Critical Roles for Puberty and Ovarian Hormones -- Introduction -- Current Models: Humans -- Eating Disorder Definitions -- Mechanisms -- Genetic Risk Factors -- Age Changes in Genetic Risk -- Pubertal Differences in Genetic Risk -- Effects of Ovarian Hormones -- Animal Models -- Future Directions -- Highlights -- References -- 5 Animal Models of Behavioral and Neuroendocrine Components of Eating Disorders -- Introduction -- Anorexia Nervosa -- Bulimia Nervosa -- Binge Eating Disorder -- Current Models: Eating Disorders, Stress, and Anxiety -- Anorexia Nervosa: Diet Restriction Model -- Anorexia Nervosa: Activity-Based Anorexia -- Animal Models of Bulimia Nervosa and Binge Eating Disorder -- Bingeing: Intermittent Access Model -- Bingeing: Diet and Stress Model -- Bingeing: Chronic Subordination Stress Model -- Purging: Sham-Feeding Model -- Bingeing: Gastric Distension Model -- Mechanisms: Neurobiology of Eating Disorders, Stress, and Anxiety -- Eating Disorders and Anxiety -- Anorexia Nervosa (AN) and Stress -- Binge Eating Disorders (BEDs) and Stress -- Highlights and Future Directions -- References -- 6 A Framework for Elucidating Causes and Consequences of Malnutrition in Anorexia Nervosa -- Introduction -- Current Models from Observations in Humans -- Distinguishing between Factors that Cause, Maintain or Result from AN -- Adaptations by Hormonal and Neural Systems Regulating Energy Balance -- Dysregulation of Stress Response Systems -- Neuroendocrine Stress Response -- Activation of the Neuronal Stress Response System -- Alterations in Higher Brain Circuits -- Corticolimbic Circuits Regulating Motivated Behavior -- Circuits Regulating Habit Formation -- Mechanisms of AN -- Early Life Stress -- Premorbid Psychiatric Disorders.
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Developing Animal Models of AN: Risk Factors for AN that are Amenable to Study in Model Organisms -- Biological Variables -- Genetic Susceptibility -- Psychosocial Stress -- Weight-Reducing Behaviors -- Current Animal Models -- Genetic Models -- Environmental Stressors -- Models Involving Combinations of Risk Factors for AN -- Social Stress + Dieting -- Dieting + Excessive Exercise -- Genetic + Social Stress + Dieting -- Future Directions -- Highlights -- Acknowledgment -- References -- III. Interaction of Stress and Drug-Seeking -- 7 Stress System Sensitivity and Emotion Regulation in Early Abstinence from Substance Use Disorders-Targets for Medications... -- Introduction -- Models of Stress and Motivation for Drugs and Alcohol -- Mechanisms: Mood and Neurobiological Mechanisms Associated With Craving in Early Abstinent Cocaine and Alcohol-Dependent In... -- Sensitivity of Core Stress Systems May Impinge Upon Regulatory Function -- The Need for Novel Medication Targets -- Highlights -- References -- 8 Effects of Stress and Chronic Alcohol Exposure on Emotional Behavior and Alcohol Consumption -- Introduction -- Current Models -- Mechanisms -- Alcohol Withdrawal, Stress, and Anxiety -- Alcohol Withdrawal, Stress, and Alcohol Drinking -- Stress and Alcohol Drinking -- Future Directions -- Highlights -- References -- Further Reading -- 9 A Genetic Mouse Model for Comorbid Alcohol Use Disorder and Posttraumatic Stress Disorder -- Introduction -- Current Animal Models of Comorbid AUD and PTSD -- A Genetic Mouse Model for Comorbid AUD and PTSD -- Mechanisms for Comorbid AUD and PTSD -- The Common Genetic Factors Hypothesis -- Testing the Common Genetic Factors Hypothesis With Acoustic Startle Phenotypes -- General Acoustic Startle Response -- Conditioned Fear-Potentiated Startle -- Prepulse Inhibition of the Acoustic Startle Response.
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The Self-Medication Hypothesis -- The HPA Axis Dysregulation Hypothesis -- Highlights -- References -- IV. Learning to Inhibit the Fear Response -- 10 Neural Circuits for Fear Relapse -- Introduction -- Current Models -- Mechanisms of Fear Relapse -- Amygdala -- Medial Prefrontal Cortex -- Hippocampus -- Bed Nucleus of the Stria Terminalis -- Highlights -- Acknowledgments -- References -- 11 Brain Mechanisms for Learning and Using Safety Signals -- Introduction -- Current Models -- Mechanisms -- Fear Circuitry -- Safety Signals in Basolateral Amygdala -- Safety Signals and Fear Expression Circuits -- Safety Signals and Sensory Systems -- Fear Modulatory Circuits: Prefrontal Cortex, Hippocampus, and Striatum -- Neurotransmitter Systems -- Studies of Safety Signals in Humans -- The Current Model of Safety Learning and Future Directions -- Highlights -- References -- 12 Animal Models to Investigate Social Support Induced Anxiety Reductions -- Introduction -- Current Models -- Preclinical Modeling of Social Support and Anxiety Interactions -- Social Isolation -- Social Buffering -- Social-Enhanced Safety Learning Models -- SoFiA Model of Social-Enhanced Safety Learning -- Mechanisms -- Neural Mechanisms of SoFiA -- Highlights -- Acknowledgment -- References -- V. Abnormal Emotional Reactivity Versus Regulation Across Disorders -- 13 Neurophysiological Assessment of Anhedonia in Depression and Schizophrenia -- Introduction -- Current Models of Anhedonia -- Clinical Descriptions -- Animal Models -- Mechanisms -- Reward Sensitivity -- Emotional Reactivity -- Future Directions -- Highlights -- References -- 14 The Role of Negative Emotion Abnormalities in Anhedonic Symptoms of Schizophrenia -- Introduction -- Current Models -- Mechanisms (A New Model) -- Negative Emotion Reactivity -- Affective Coactivation -- Basic Concepts in Emotion Regulation.
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Emotion Regulation in SZ -- Future Directions -- Highlights -- References -- 15 Motivational Impairments in Psychotic and Depressive Pathology: Psychological and Neural Mechanisms -- Introduction -- Current Models -- Mechanisms -- Initial Responsiveness to Reward (Hedonics and Liking) -- Depression -- Schizophrenia -- Reward Anticipation, Reward Prediction Error, and Reinforcement Learning -- Depression -- Schizophrenia -- Summary of Reward Anticipation, Prediction and Reinforcement Learning -- Reward Valuation -- Depression -- Schizophrenia -- Reward Valuation-Effort -- Depression -- Schizophrenia -- Cognitive Control Goal-Directed Action -- Depression -- Schizophrenia -- Summary and Future Directions -- Highlights -- References -- Further Reading -- Perspectives and Future Directions for Integrating Animal and Human Neurobiology Research on Abnormal Emotion and Motivated... -- Experimental Models and Methods -- Behavioral Outcome Measurements -- Genetic Markers -- Neural Circuits -- Future Directions -- Index -- Back Cover.
Language:
English
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