Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (586 pages)

Edition: 1st ed.

ISBN: 9780128148105

Note: Intro -- Chromatin: Structure, Function, and History -- Copyright -- Contents -- Preface -- Part 1: Chromatin structure -- Chapter 1: Early history -- 1869-1950: Identification of nucleic acid and the ``dark ages´´ of chromatin research -- Prelude to the nucleosome: 1950s and 1960s -- A model for the nucleosome: A new era of chromatin biology begins -- References -- Chapter 2: The nucleosome unveiled -- From model to structure: The nucleosome core particle -- Size and shape -- The path of the DNA -- Histones in the nucleosome -- The nucleosome unveiled: High-resolution structure of the core particle -- References -- Chapter 3: Chromatin compaction -- Early observations -- Factors influencing chromatin folding -- Cations -- Linker histones -- Histone tails -- The structure of compact chromatin -- Compact chromatin in living cells -- Chromosome architecture -- Chromosome territories -- Loops -- Topologically associating domains or TADs -- Liquid-liquid condensates -- Heterochromatin -- Heterochromatin in budding yeast -- References -- Chapter 4: Nucleosomes in context: Positioning, occupancy, and spacing -- Overview -- Rotational vs translational nucleosome positioning -- Nucleosome spacing -- Methods for determining nucleosome positioning -- Local analysis of nucleosome positioning -- Global analysis of nucleosome positioning -- First studies of nucleosome positioning -- Nucleosome positioning in vivo -- Heterogeneity in nucleosome positioning: Single cell approaches -- Mechanisms of nucleosome positioning -- Role of DNA sequence -- DNA bending and nucleosome positioning -- Poly(dA)-poly(dT) tracts and nucleosome exclusion -- Cis vs trans determinants of nucleosome positioning and occupancy -- Factors that contribute to nucleosome organization in trans -- Nucleosome-positioning proteins -- Nucleosome-excluding proteins. , Remodelers and nucleosome positioning -- Barrier elements, nucleosome spacing, and chromatin remodelers -- NDRs and ``fragile´´ nucleosomes -- References -- Chapter 5: Histones and variants -- General considerations -- Histone deposition and chromatin maturation following DNA replication -- Histone chaperones -- Histone variation: Early work -- Sea urchins: Variant histones expressed during development -- Other species -- Evolution of the histones -- Canonical histones: Nonallelic variants -- Histone mutants -- Specialized variants -- H2A.Z -- H2A.X -- H2A.B and the short H2A variants -- MacroH2A -- CenH3 -- H3.3 -- References -- Part 2: Chromatin function -- Chapter 6: Chromatin remodeling -- The SWI/SNF complex -- Yeast genetics points to a chromatin remodeling machine -- swi and sin mutants -- snf and ssn mutants -- spt mutants -- Connections between swi, snf, and spt mutants and chromatin -- The SWI/SNF complex as a chromatin remodeling machine -- More remodeling machines -- SWI/SNF in other species -- BAF mutations and cancer -- RSC: A close cousin of the SWI/SNF complex -- An expanded family of remodelers -- ISWI -- INO80 -- Chd1 and the Mi-2/NuRD complexes -- Structure and mechanism of remodelers -- Function and localization of remodelers -- References -- Chapter 7: Histone modifications -- Overview -- Early history of protein and histone modification -- Histone acetylation and deacetylation -- Histone acetylation before Gcn5 -- Paradigm shift part 1: A histone acetyltransferase regulates transcription -- Gcn5 and the SAGA complex -- The SAGA complex -- Histone acetylation and transcriptional activation: Mechanisms -- More HATs -- CBP/p300 -- MYST family -- Rtt109 and H3K56ac -- Putative HATs -- Histone deacetylation before Rpd3 -- Paradigm shift part 2: A histone deacetylase is a transcriptional repressor -- More HDACs and their complexes. , Class I HDAC complexes -- Class III HDACs: The sirtuins -- Specificity and genomic targeting of HDACs -- Histone methylation and demethylation -- Histone methyltransferases -- Histone arginine methylation -- Histone lysine methylation -- Histone demethylases -- Other modifications -- Phosphorylation -- Histone ubiquitination and sumoylation -- ADP-ribosylation, glycosylation, and more -- Cross-talk -- The histone code -- References -- Chapter 8: Chromatin and transcription -- Transcription: A brief review -- Early investigations -- Prokaryotic polymerases and RNA polymerase III -- Pol II -- Nucleosomal inhibition of transcription can be overcome by activators: In vitro studies -- In vivo studies -- Perturbation of histone gene expression in budding yeast -- Model promoters: PHO5 and MMTV -- Ordered recruitment -- Transcription factor access in a chromatin milieu -- Nucleosome exclusion -- Nucleosome binders and pioneer factors -- Facilitated accessibility -- Promoter chromatin structure reflects function -- Chromatin-mediated gene regulation in development: The polycomb group and trithorax group complexes -- Transcribing through chromatin -- Elongation factors -- Cryptic transcriptional initiation -- Epigenetics -- DNA methylation -- Chromatin-mediated inheritance -- References -- Epilogue -- Index.

Additional Edition: Print version: Morse, Randall H. Chromatin San Diego : Elsevier Science & Technology,c2024 ISBN 9780128148099

Language: English

UID:

Format: 1 online resource (586 pages)

Edition: 1st ed.

ISBN: 9780128148105

Note: Intro -- Chromatin: Structure, Function, and History -- Copyright -- Contents -- Preface -- Part 1: Chromatin structure -- Chapter 1: Early history -- 1869-1950: Identification of nucleic acid and the ``dark ages´´ of chromatin research -- Prelude to the nucleosome: 1950s and 1960s -- A model for the nucleosome: A new era of chromatin biology begins -- References -- Chapter 2: The nucleosome unveiled -- From model to structure: The nucleosome core particle -- Size and shape -- The path of the DNA -- Histones in the nucleosome -- The nucleosome unveiled: High-resolution structure of the core particle -- References -- Chapter 3: Chromatin compaction -- Early observations -- Factors influencing chromatin folding -- Cations -- Linker histones -- Histone tails -- The structure of compact chromatin -- Compact chromatin in living cells -- Chromosome architecture -- Chromosome territories -- Loops -- Topologically associating domains or TADs -- Liquid-liquid condensates -- Heterochromatin -- Heterochromatin in budding yeast -- References -- Chapter 4: Nucleosomes in context: Positioning, occupancy, and spacing -- Overview -- Rotational vs translational nucleosome positioning -- Nucleosome spacing -- Methods for determining nucleosome positioning -- Local analysis of nucleosome positioning -- Global analysis of nucleosome positioning -- First studies of nucleosome positioning -- Nucleosome positioning in vivo -- Heterogeneity in nucleosome positioning: Single cell approaches -- Mechanisms of nucleosome positioning -- Role of DNA sequence -- DNA bending and nucleosome positioning -- Poly(dA)-poly(dT) tracts and nucleosome exclusion -- Cis vs trans determinants of nucleosome positioning and occupancy -- Factors that contribute to nucleosome organization in trans -- Nucleosome-positioning proteins -- Nucleosome-excluding proteins. , Remodelers and nucleosome positioning -- Barrier elements, nucleosome spacing, and chromatin remodelers -- NDRs and ``fragile´´ nucleosomes -- References -- Chapter 5: Histones and variants -- General considerations -- Histone deposition and chromatin maturation following DNA replication -- Histone chaperones -- Histone variation: Early work -- Sea urchins: Variant histones expressed during development -- Other species -- Evolution of the histones -- Canonical histones: Nonallelic variants -- Histone mutants -- Specialized variants -- H2A.Z -- H2A.X -- H2A.B and the short H2A variants -- MacroH2A -- CenH3 -- H3.3 -- References -- Part 2: Chromatin function -- Chapter 6: Chromatin remodeling -- The SWI/SNF complex -- Yeast genetics points to a chromatin remodeling machine -- swi and sin mutants -- snf and ssn mutants -- spt mutants -- Connections between swi, snf, and spt mutants and chromatin -- The SWI/SNF complex as a chromatin remodeling machine -- More remodeling machines -- SWI/SNF in other species -- BAF mutations and cancer -- RSC: A close cousin of the SWI/SNF complex -- An expanded family of remodelers -- ISWI -- INO80 -- Chd1 and the Mi-2/NuRD complexes -- Structure and mechanism of remodelers -- Function and localization of remodelers -- References -- Chapter 7: Histone modifications -- Overview -- Early history of protein and histone modification -- Histone acetylation and deacetylation -- Histone acetylation before Gcn5 -- Paradigm shift part 1: A histone acetyltransferase regulates transcription -- Gcn5 and the SAGA complex -- The SAGA complex -- Histone acetylation and transcriptional activation: Mechanisms -- More HATs -- CBP/p300 -- MYST family -- Rtt109 and H3K56ac -- Putative HATs -- Histone deacetylation before Rpd3 -- Paradigm shift part 2: A histone deacetylase is a transcriptional repressor -- More HDACs and their complexes. , Class I HDAC complexes -- Class III HDACs: The sirtuins -- Specificity and genomic targeting of HDACs -- Histone methylation and demethylation -- Histone methyltransferases -- Histone arginine methylation -- Histone lysine methylation -- Histone demethylases -- Other modifications -- Phosphorylation -- Histone ubiquitination and sumoylation -- ADP-ribosylation, glycosylation, and more -- Cross-talk -- The histone code -- References -- Chapter 8: Chromatin and transcription -- Transcription: A brief review -- Early investigations -- Prokaryotic polymerases and RNA polymerase III -- Pol II -- Nucleosomal inhibition of transcription can be overcome by activators: In vitro studies -- In vivo studies -- Perturbation of histone gene expression in budding yeast -- Model promoters: PHO5 and MMTV -- Ordered recruitment -- Transcription factor access in a chromatin milieu -- Nucleosome exclusion -- Nucleosome binders and pioneer factors -- Facilitated accessibility -- Promoter chromatin structure reflects function -- Chromatin-mediated gene regulation in development: The polycomb group and trithorax group complexes -- Transcribing through chromatin -- Elongation factors -- Cryptic transcriptional initiation -- Epigenetics -- DNA methylation -- Chromatin-mediated inheritance -- References -- Epilogue -- Index.

Additional Edition: Print version: Morse, Randall H. Chromatin San Diego : Elsevier Science & Technology,c2024 ISBN 9780128148099

Language: English

UID:

Format: 1 online resource (586 pages)

Edition: 1st ed.

ISBN: 9780128148105

Note: Intro -- Chromatin: Structure, Function, and History -- Copyright -- Contents -- Preface -- Part 1: Chromatin structure -- Chapter 1: Early history -- 1869-1950: Identification of nucleic acid and the ``dark ages´´ of chromatin research -- Prelude to the nucleosome: 1950s and 1960s -- A model for the nucleosome: A new era of chromatin biology begins -- References -- Chapter 2: The nucleosome unveiled -- From model to structure: The nucleosome core particle -- Size and shape -- The path of the DNA -- Histones in the nucleosome -- The nucleosome unveiled: High-resolution structure of the core particle -- References -- Chapter 3: Chromatin compaction -- Early observations -- Factors influencing chromatin folding -- Cations -- Linker histones -- Histone tails -- The structure of compact chromatin -- Compact chromatin in living cells -- Chromosome architecture -- Chromosome territories -- Loops -- Topologically associating domains or TADs -- Liquid-liquid condensates -- Heterochromatin -- Heterochromatin in budding yeast -- References -- Chapter 4: Nucleosomes in context: Positioning, occupancy, and spacing -- Overview -- Rotational vs translational nucleosome positioning -- Nucleosome spacing -- Methods for determining nucleosome positioning -- Local analysis of nucleosome positioning -- Global analysis of nucleosome positioning -- First studies of nucleosome positioning -- Nucleosome positioning in vivo -- Heterogeneity in nucleosome positioning: Single cell approaches -- Mechanisms of nucleosome positioning -- Role of DNA sequence -- DNA bending and nucleosome positioning -- Poly(dA)-poly(dT) tracts and nucleosome exclusion -- Cis vs trans determinants of nucleosome positioning and occupancy -- Factors that contribute to nucleosome organization in trans -- Nucleosome-positioning proteins -- Nucleosome-excluding proteins. , Remodelers and nucleosome positioning -- Barrier elements, nucleosome spacing, and chromatin remodelers -- NDRs and ``fragile´´ nucleosomes -- References -- Chapter 5: Histones and variants -- General considerations -- Histone deposition and chromatin maturation following DNA replication -- Histone chaperones -- Histone variation: Early work -- Sea urchins: Variant histones expressed during development -- Other species -- Evolution of the histones -- Canonical histones: Nonallelic variants -- Histone mutants -- Specialized variants -- H2A.Z -- H2A.X -- H2A.B and the short H2A variants -- MacroH2A -- CenH3 -- H3.3 -- References -- Part 2: Chromatin function -- Chapter 6: Chromatin remodeling -- The SWI/SNF complex -- Yeast genetics points to a chromatin remodeling machine -- swi and sin mutants -- snf and ssn mutants -- spt mutants -- Connections between swi, snf, and spt mutants and chromatin -- The SWI/SNF complex as a chromatin remodeling machine -- More remodeling machines -- SWI/SNF in other species -- BAF mutations and cancer -- RSC: A close cousin of the SWI/SNF complex -- An expanded family of remodelers -- ISWI -- INO80 -- Chd1 and the Mi-2/NuRD complexes -- Structure and mechanism of remodelers -- Function and localization of remodelers -- References -- Chapter 7: Histone modifications -- Overview -- Early history of protein and histone modification -- Histone acetylation and deacetylation -- Histone acetylation before Gcn5 -- Paradigm shift part 1: A histone acetyltransferase regulates transcription -- Gcn5 and the SAGA complex -- The SAGA complex -- Histone acetylation and transcriptional activation: Mechanisms -- More HATs -- CBP/p300 -- MYST family -- Rtt109 and H3K56ac -- Putative HATs -- Histone deacetylation before Rpd3 -- Paradigm shift part 2: A histone deacetylase is a transcriptional repressor -- More HDACs and their complexes. , Class I HDAC complexes -- Class III HDACs: The sirtuins -- Specificity and genomic targeting of HDACs -- Histone methylation and demethylation -- Histone methyltransferases -- Histone arginine methylation -- Histone lysine methylation -- Histone demethylases -- Other modifications -- Phosphorylation -- Histone ubiquitination and sumoylation -- ADP-ribosylation, glycosylation, and more -- Cross-talk -- The histone code -- References -- Chapter 8: Chromatin and transcription -- Transcription: A brief review -- Early investigations -- Prokaryotic polymerases and RNA polymerase III -- Pol II -- Nucleosomal inhibition of transcription can be overcome by activators: In vitro studies -- In vivo studies -- Perturbation of histone gene expression in budding yeast -- Model promoters: PHO5 and MMTV -- Ordered recruitment -- Transcription factor access in a chromatin milieu -- Nucleosome exclusion -- Nucleosome binders and pioneer factors -- Facilitated accessibility -- Promoter chromatin structure reflects function -- Chromatin-mediated gene regulation in development: The polycomb group and trithorax group complexes -- Transcribing through chromatin -- Elongation factors -- Cryptic transcriptional initiation -- Epigenetics -- DNA methylation -- Chromatin-mediated inheritance -- References -- Epilogue -- Index.

Additional Edition: Print version: Morse, Randall H. Chromatin San Diego : Elsevier Science & Technology,c2024 ISBN 9780128148099

Language: English