UID:
edoccha_9960834284402883
Format:
1 online resource (x, 243 pages) :
,
illustrations
ISBN:
9780128209103
Content:
SERS for Point-of-care and Clinical Applications focuses on the use of Surface-Enhanced Raman Spectroscopy (also known as Surface-Enhanced Raman Scattering) techniques in clinical and point-of-care settings. Sections provide an overview of SERS biomedical applications, providing in-depth information about point-of-care and clinical applications of SERS using specific examples from current literature. These applications are not always immediately evident to newcomers in the field, as Raman and SERS are often introduced as analytical methods for chemical analysis.
Note:
Front Cover -- SERS for Point-of-care and Clinical Applications -- SERS for Point-of-care and Clinical Applications -- Copyright -- Contents -- Contributors -- Editor biography -- 1 - Data analysis in SERS diagnostics -- Introduction -- General data processing workflow -- Study definition and data collection -- Data handling considerations (data structures, organization) -- Metadata organization -- A bit of statistics -- Survey of software available -- Data integrity -- Outliers -- Data preprocessing -- Spectral preprocessing (row-wise methods) -- Normalization -- Model-based methods -- Column transformations -- Models -- Exploratory data analysis (unsupervised learning) -- Regression -- Principal component regression -- Partial least squares regression -- Classification -- Linear discriminant analysis and quadratic discriminant analysis -- Logistic regression -- Principal component analysis and partial least squares as preprocessing: PCA-LDA, PLS-LDA, PLS-LR, etc. -- Soft independent modeling of class analogies -- Nonlinear models -- k nearest neighbors -- Support vector machines -- Artificial neural networks -- Verification of results -- Bias and variance in verification -- Verification schemes -- Validation studies and assessing ruggedness -- Hold out/independent test sets -- Autoprediction (training error) -- Resampling: cross validation and out-of-bootstrap -- Figures of merit -- Regression -- Diagnostic plots -- Diagnostic plots -- Classification -- Sensitivity, specificity, predictive values, and similar proportions -- Sensitivity, specificity, predictive values, and similar proportions -- Model stability and overfitting -- Hyperparameter optimization -- Concluding remarks -- References -- 2 - Label-free SERS techniques in biomedical applications -- Introduction -- Oncological diseases -- Neurological diseases -- Infectious diseases.
,
Future challenges and perspectives -- References -- 3 - SERS probes and tags for biomedical applications -- Introduction -- Surface-enhanced Raman scattering -- Design considerations -- Particle type -- Raman reporter -- Surface coating -- Targeting -- Sensing mechanism -- References -- 4 - SERS biosensors for point-of-care infectious disease diagnostics -- Introduction -- Antibody-based SERS biosensors -- Aptamer-based SERS biosensors -- Nucleic acid-based SERS biosensors -- SERS biosensors without bioreceptor -- Conclusion -- References -- 5 - SERS-based molecular sentinel nanoprobes for nucleic acid biomarker detection -- Introduction -- Development of the iMS nanoprobe for label-free homogenous biosensing -- Silver-coated gold nanostars for SERS detection -- Detection scheme of the SERS iMS nanoprobe -- Development of iMS for detection of microRNA biomarkers -- Detection of miRNA biomarkers within biological samples -- RNA extracted from cancer cell lines -- Clinical evaluation of miRNA cancer biomarker detection using iMS nanoprobes -- Multiplexed detection of miRNA biomarkers -- Development of multiplexing technique -- Multiplex detection of endogenous targets extracted from breast cancer cell lines -- iMS bioassay-on-chip -- Conclusion -- References -- 6 - SERS detection of oral and gastrointestinal cancers -- Introduction -- Oral cancer -- Introduction -- Optimization and design considerations -- Discussion and future directions -- Esophageal cancer -- Introduction -- Optimization and design considerations -- Discussion and future directions -- Stomach cancer -- Introduction -- Optimization and design considerations -- Discussion and future directions -- Intestinal cancer -- Introduction -- Optimization and design considerations -- Discussion and future directions -- Concluding remarks -- References -- 7 - In vivo imaging with SERS nanoprobes.
,
Introduction -- Raman imaging with SERS nanoprobes -- In vivo imaging with SERS nanoparticles-multiplexing potential -- Biological barriers and opportunities -- Passive tumor targeting -- Opsonization/sequestration by the mononuclear phagocyte system -- Sequestration based on physicochemical properties -- Blood-brain barrier -- Molecular targeting -- Ex vivo SERS-based molecular imaging -- In vivo molecular imaging with SERS nanoprobes -- Multimodal imaging using SERS nanoprobes -- The future of in vivo Raman imaging -- Imaging deeper -- SERS and endoscopy -- Spatially offset optics -- Imaging faster -- Nanoprobe administration -- Conclusion -- References -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Back Cover.
Additional Edition:
Print version: Fales, Andrew SERS for Point-Of-care and Clinical Applications San Diego : Elsevier,c2022 ISBN 9780128205488
Language:
English
Bookmarklink
