UID:
edoccha_9961017315502883
Format:
1 online resource (264 pages)
ISBN:
0-12-821542-9
Series Statement:
Micro and nano technologies
Content:
Graphene Based Biomolecular Electronic Devices outlines the fundamental concepts related to graphene and electronics, along with a description of various advanced and emerging applications of graphene-based bioelectronics. The book includes coverage of biosensors, energy storage devices such as biofuel cells, stretchable and flexible electronics, drug delivery systems, tissue engineering, and 3D printed graphene in bioelectronics. Taking an interdisciplinary approach, it explores the synergy produced due to charge transfer between biomolecules and graphene and will help the reader understand the promising bioelectronic applications of graphene-based devices. Graphene has applications in semiconductor electronics, replacing the use of traditional silicon-based devices due to its semi-metallic nature and tuneable energy band gap properties. The tuning of electron transfer with redox properties of biomolecules could potentially lead to the development of miniaturized bioelectronic devices. Thus, graphene, with its unique sensing characteristics, has emerged as an attractive material to produce biomolecular electronic devices.
Note:
Intro -- Graphene Based Biomolecular Electronic Devices -- Copyright -- Contents -- Preface -- 1 Graphene-Fundamentals -- 1.1 Introduction -- 1.2 History of graphene -- 1.3 Graphene synthesis -- 1.3.1 Top-down approach -- Mechanical exfoliation and cleavage -- Chemical exfoliation -- 1.3.2 Bottom-up approach -- Epitaxial growth -- Chemical vapour deposition (CVD) -- 1.4 Morphologies of graphene -- 1.5 Electronic properties of graphene -- 1.6 Graphene-biomolecular interactions -- 1.6.1 Interactions in DNA-graphene hybrids -- Non-covalent interactions -- Covalent interactions -- 1.6.2 Interactions in peptide-graphene hybrids -- Non-covalent interactions -- Covalent interactions -- 1.6.3 Interactions in protein-graphene hybrids -- Non-covalent interactions -- Covalent interactions -- 1.6.4 Interactions in carbohydrates-graphene hybrids -- Non-covalent interactions -- Covalent interactions -- 1.7 Graphene-based hybrid biomaterials -- 1.7.1 Graphene hybrids in tissue engineering -- 1.7.2 Graphene hybrids in drug delivery -- 1.8 Conclusions -- References -- 2 Graphene-Based Transduction Systems in Biosensors -- 2.1 Introduction -- 2.2 Graphene-based transduction systems -- 2.2.1 Electrochemical biosensors -- 2.2.2 Piezoelectric biosensors -- 2.2.3 Optical biosensors -- 2.3 Conclusions -- References -- 3 Graphene in Field Effect Transistor-Based Biosensors -- 3.1 Introduction -- 3.2 Graphene Bio-FET -- Substrate preparation -- Graphene selection -- Exfoliation and cleavage -- Chemically prepared graphene -- Chemical vapour deposition -- 3.2.1 Placement of graphene on suitable substrates -- Exfoliated graphene -- Reduced graphene oxide -- 3.2.2 Fabrication of FET sensors -- Non-covalent and covalent functionalization -- 3.2.3 Non-covalent functionalization -- Covalent attachment -- Anti-biofouling.
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3.2.4 Some graphene-based FET biosensors -- Genomic detection -- Biomarker detection -- Cellular detection -- 3.3 Bio-FET-based label-free detection mechanism -- 3.3.1 Indirect detection of macromolecules -- 3.3.2 Direct detection of macromolecules -- Detection of oligonucleotides -- 3.3.3 Detection of proteins -- 3.4 Challenges of using graphene in fabrication of FET-based sensing devices -- Protocols for GFET device fabrications -- References -- 4 Graphene-Based Biosensors for Detection of Protein and Nucleic Acid -- 4.1 Introduction -- 4.2 Graphene-based biosensors for nucleic acid detection -- 4.2.1 Introduction -- 4.2.2 Graphene-based aptamer biosensors -- 4.2.3 Graphene-based DNA (deoxyribonucleic acid) biosensors -- 4.2.4 Graphene-based PNA (peptide nucleic acid) biosensors -- 4.3 Graphene-based biosensors for protein detection -- 4.3.1 Introduction -- 4.3.2 Graphene-based immunosensors -- 4.3.3 Graphene-based enzyme biosensors -- 4.4 Advanced applications of graphene-based biosensors -- 4.4.1 Introduction -- 4.4.2 Graphene-based biosensors in microfluidic chips -- 4.4.3 Graphene-based biosensors for point-of-care diagnostics -- 4.4.4 Graphene-based biosensors in integrated lab-on-a-chip -- 4.5 Protocols -- 4.6 Conclusions -- References -- 5 Graphene-Based Wearable Biosensors -- 5.1 Introduction -- 5.2 Graphene-based flexible and stretchable materials -- 5.2.1 Bio-integrated devices -- 5.2.2 Wireless biosensors -- 5.3 Applications of wearable biosensors -- 5.3.1 Electrophysiological measurements -- 5.3.2 Biomolecular detection -- 5.3.3 Kinematic detection -- 5.4 Challenges and future prospectus -- 5.5 Conclusions -- References -- 6 Graphene 3D Printing -- 6.1 Introduction -- 6.2 Direct 3D printing -- 6.2.1 Direct ink writing for bioelectronic applications -- 6.2.2 Direct bioprinting.
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6.3 3D freeze printing -- 6.4 Digital light processing 3D printing -- 6.5 Stereolithography -- 6.5.1 Graphene nanofiller in stereolithographic printing -- 6.6 Fused deposition technique -- 6.7 Conclusions -- References -- 7 Graphene-Based Microbial Fuel Cell -- 7.1 Introduction -- 7.2 Modified graphene as electrode material -- 7.3 Synthesis of graphene used for electrode material -- 7.4 MFC designing using graphene-based materials -- 7.5 Graphene as an anode material -- 7.6 Graphene as a cathode material -- 7.7 MFC-based bioelectronic devices -- 7.8 Conclusions -- References -- 8 Graphene-Based Drug Delivery System -- 8.1 Introduction -- 8.2 Graphene-based drug delivery nano-vehicles -- 8.3 Graphene interaction with cell membrane -- 8.4 Impact of graphene on a human body -- 8.5 Conclusions -- References -- 9 Graphene in Tissue Engineering and Electronics: Future Prospects and Challenges -- 9.1 Introduction -- 9.2 Fabrication of conductive scaffolds -- 9.2.1 Chemical vapour deposition (CVD) -- 9.2.2 3D printing -- 9.2.3 Electrospinning -- 9.2.4 Freeze drying -- 9.2.5 Free radical polymerization -- 9.2.6 Self-assembly -- 9.2.7 Direct vacuum filtration method -- 9.3 Molecular interactions in biopolymers and graphene -- 9.3.1 Graphene-SF hybrids -- 9.3.2 Graphene-amyloid hybrids -- 9.3.3 Graphene-chitosan hybrids -- 9.4 Cellular behaviour on conductive scaffolds -- 9.4.1 Neural regeneration -- 9.4.2 Stem cell differentiation -- 9.5 Scaffold as an electronic sensor -- 9.6 Challenges -- 9.7 Protocols -- 9.7.1 Graphene-SF synthesis -- 9.7.2 Graphene-chitosan synthesis -- References -- 10 Commercial Prospects of Graphene-Based Biomolecular Electronic Devices and Challenges -- 10.1 Introduction -- 10.2 Graphene-based electronic devices -- 10.3 Graphene-based biosensors -- 10.4 Graphene-based biofuel cells.
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10.5 Future challenges -- 10.6 Conclusions -- References -- Index.
Additional Edition:
Print version: Malhotra, Bansi D. Graphene Based Biomolecular Electronic Devices San Diego : Elsevier,c2023 ISBN 9780128215418
Language:
English
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