Kooperativer Bibliotheksverbund

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Format: 1 online resource (821 pages)

ISBN: 0-12-824131-4

Note: Front Cover -- Aging -- Copyright Page -- Contents -- List of contributors -- Foreword -- Preface -- 1 The societal burden of aging -- 1 Global aging and health determinants in a changing world -- 1.1 Introduction -- 1.2 The geographies of a global trend -- 1.2.1 Global patterns and projections -- 1.2.2 Multiscale intraregional variations of the aging process -- 1.3 Environmental health in later life -- 1.3.1 From successful aging to the role of place and inequities -- 1.3.2 How environment affects physical health in old age -- 1.3.3 The subjective experience of place: place attachment and residential normalcy -- 1.4 Global stressors in a changing world -- 1.4.1 Welfare state and neoliberalism -- 1.4.2 Climate change and health in old age -- 1.4.3 Migrations and health in old age -- 1.4.4 Discrimination as a health issue for older persons -- 1.5 Conclusion -- Acknowledgments -- References -- 2 Flagship initiatives for healthy living and active aging in Europe: the European Innovation Partnership on Active and Hea... -- 2.1 Demographic changes and aging -- 2.2 The European Innovation Partnership on Active and Healthy Ageing -- 2.2.1 European Innovation Partnership on Active and Healthy Ageing cross-cutting initiatives -- 2.3 Reference sites-case studies -- 2.3.1 Ageing@Coimbra Reference Site -- 2.3.2 The Healthy Ageing Network Northern Netherlands -- 2.3.3 Valencia region Reference Site -- 2.3.4 Andalusia Reference Site -- 2.3.5 The Lodz4Generations Reference Site -- 2.3.6 Campania Reference Site (ProMIS network) -- 2.3.7 MACVIA-France Reference Site -- 2.4 Reference Site Collaborative Network -- 2.5 Transition from Horizon 2020 to Horizon Europe-the role of IN-4-Active and Healthy Ageing -- 2.6 Future perspectives -- Acknowledgment -- References -- 3 Aging in Africa, challenges and opportunities-the particular case of Cabo Verde. , 3.1 Aging in Africa and West African Region -- 3.2 Geography and climate of Cabo Verde -- 3.3 Cabo Verde, the historical healthy islands -- 3.4 Epidemiology of slave society -- 3.5 Cabo Verde Famines -- 3.6 Cabo Verdean population genetics -- 3.7 Age pyramid of Cabo Verdean population -- 3.8 Urbanization of Cabo Verdean population -- 3.9 Aging and the emergence of a new demographic model -- 3.10 Elderly in Cabo Verde -- 3.11 Health and national health service-philosophy, structures, and budget -- 3.12 Healthy and active aging policies -- 3.13 Aging and poverty -- 3.14 Aging and gender -- 3.15 To a healthy living and active aging in Cabo Verde-the future -- References -- 4 Flagship initiatives to prevent and treat diabetes as a burden of western societies -- 4.1 Introduction -- 4.1.1 Demographics of diabetes and prediabetes -- 4.1.2 Healthcare literacy and numeracy -- 4.1.3 Food insecurity and dietary quality -- 4.1.4 Community engagement -- 4.2 Impact of research: prediabetes -- 4.2.1 The diabetes prevention program study -- 4.2.2 The finnish diabetes prevention study -- 4.3 Lifestyle interventions -- 4.3.1 The national diabetes prevention program -- 4.3.2 Exercise -- 4.3.3 Pharmacologic therapy in prediabetes -- 4.4 Impact of research: diabetes -- 4.4.1 Diabetes self-management education -- 4.5 Summary and conclusions -- References -- 5 Determining factors on active aging in Asia and Oceania: a systematic review -- 5.1 Introduction -- 5.2 Methodology -- 5.2.1 Population aging in Asia and Oceania -- 5.2.2 Data sources and search strategies -- 5.2.3 Study selection -- 5.2.4 Bias assessment -- 5.2.5 Data extraction -- 5.3 Results -- 5.3.1 Exergaming/active video games -- 5.3.2 Health wearables and activity trackers -- 5.3.3 Smartphones -- 5.3.4 Web-based programs -- 5.4 Discussion and concluding remarks -- References. , 6 Healthy living and active aging in Latin America and the Caribbean countries: biological, demographic, and epidemiologica... -- 6.1 Introduction -- 6.2 Demographic and epidemiological changes in the Latin America and the Caribbean countries -- 6.3 Age-related biological changes and diseases in the context of Latin America and the Caribbean countries -- 6.3.1 Immunosenescence and infectious diseases -- 6.3.2 Age-related intestinal microbiota changes: the role in neurodegenerative and metabolic diseases -- 6.3.3 Common age-related diseases: cancer, vascular diseases, diabetes and neurodegenerative disorders -- 6.3.3.1 Cancer -- 6.3.3.2 Cardiovascular diseases -- 6.3.3.3 Diabetes mellitus -- 6.3.3.4 Neurodegenerative disorders -- 6.4 Health and social initiatives for the promotion of healthy living and active aging -- 6.4.1 Age-friendly initiatives -- 6.4.2 Labor force participation and active aging -- 6.5 Selected health issues among older people: evidence from long-term cohorts in Latin America -- 6.6 Conclusion -- References -- 2 The biology of aging -- 7 Identification of metrics of molecular and cellular resilience in humans and animal models -- 7.1 Biomedicine is focused on disease, not health -- 7.2 Comorbidities are the prevailing characteristic of older age -- 7.3 Chronological versus physiological age -- 7.4 Linking aging to disease: geroscience principles -- 7.5 A common thread: improvement of resilience -- 7.6 Defining resilience at the molecular level -- 7.7 Measuring molecular resilience -- 7.8 We need to develop resilience metrics in animal models -- 7.9 Translation of resilience measurements to humans -- 7.10 Conclusions -- References -- 8 A metabolic and mitochondrial angle on aging -- Abbreviations -- 8.1 Aging and longevity: revisiting the evolutionary perspectives and controversies. , 8.2 Aging and longevity: challenging the traditional views for mitochondrial-derived oxidative stress -- 8.3 Changes of mitochondrial function and structure associated with aging -- 8.3.1 Oxidative phosphorylation and aging -- 8.3.2 Mitochondrial morphology and dynamics in aging -- 8.4 A metabolic angle on aging -- 8.4.1 Carbohydrate metabolism and aging -- 8.4.2 Lipid metabolism and aging -- 8.4.3 Protein metabolism and aging -- 8.4.4 Nutrient metabolism and caloric restriction -- 8.5 Oxidative stress and aging -- 8.5.1 Reactive oxygen species and their reactions -- 8.5.2 Reactive oxygen species as the cause of aging -- 8.5.3 Antioxidant defense in aging -- 8.5.4 Mitochondrial free radical theory of aging -- 8.5.5 Accumulation of reactive oxygen species-induced damage with aging -- 8.5.6 Age-related oxidative modifications of mitochondria -- 8.6 Potential strategies against aging to increase longevity -- 8.6.1 Metabolic control-related approaches -- 8.6.1.1 Caloric/dietary restriction -- 8.6.1.2 Melatonin -- 8.6.1.3 Sirtuins activators -- 8.6.1.3.1 Resveratrol showed cytotoxicity against several cancers (namely leukemia, skin and prostate cancer) -- 8.6.1.3.2 Food nutrients -- 8.6.1.3.3 Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), a diarylheptanoid derived from the rhizom... -- 8.6.1.4 Sirtuin inhibitors -- 8.6.1.5 Mitochondrial uncoupling -- 8.6.1.5.1 UCP1 was first identified in the 1970s and is the most well-known member of UCPs -- 8.6.1.5.2 UCP2, UCP3 and UCP4 -- 8.6.1.5.3 2,4-dinitrophenol (DNP) and carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP) are well-studied pharmac... -- 8.6.1.6 Physical activity -- 8.6.2 Mitochondria-related antioxidant approaches -- 8.6.2.1 What can we learn from the "eternal youth" of the naked mole rat? -- 8.6.2.2 Mitochondria-targeted antioxidants in delayed aging. , 8.6.2.2.1 MitoQ -- 8.6.2.2.2 SkQ1 -- 8.6.2.2.3 AntiOxBEN2 and AntiOxCIN4 -- 8.6.2.2.4 Other mitochondrially-targeted antioxidants -- 8.6.2.2.4.1 TEMPO and Mito-TEMPO -- 8.6.2.2.4.2 Szeto-Schiller (SS) peptides -- 8.7 Conclusions -- Acknowledgments -- References -- 9 Intercellular communication and aging -- 9.1 Importance of intercellular communication -- 9.2 The defining features of senescence -- 9.3 The mechanisms responsible for the induction of cellular senescence -- 9.4 Senescence associated secretory phenotype -- 9.5 Intercellular communication mediated by gap junctions and connexin channels -- 9.6 Intercellular communication mediated by tunneling nanotubes -- 9.7 Intercellular communication mediated by extracellular vesicles -- 9.8 Concluding remarks -- Acknowledgments -- References -- 10 Genomic instability and aging -- 10.1 Introduction -- 10.2 DNA strand breakage-induced genomic instability -- 10.3 Replication-induced genomic instability -- 10.3.1 Replication stress -- 10.3.2 Translesion DNA synthesis -- 10.3.3 Mismatch repair -- 10.4 Transcription-induced genomic instability -- 10.4.1 Transcription-coupled repair -- 10.4.2 Transcription-replication conflicts -- 10.5 Nucleotide pools -- 10.6 Mitochondrial functions in genomic integrity -- 10.6.1 Mitochondrial oxidative stress -- 10.6.2 FOXO in oxidative DNA damage response -- 10.6.3 Mitochondrial genome maintenance -- 10.6.4 Mitochondrial dysfunction -- 10.6.5 Mitophagy -- 10.7 Genomic instability in health and disease -- 10.7.1 Longevity -- 10.7.2 Progeroid syndromes -- 10.7.3 Cancer -- 10.7.4 Neurodegeneration -- 10.8 Aging interventions activating DNA repair -- 10.8.1 Exercise -- 10.8.2 Dietary restriction -- 10.8.3 Nicotinamide adenine dinucleotide -- 10.9 Conclusion and future perspectives -- Acknowledgments -- References -- 11 Telomeres and cell homeostasis in aging. , 11.1 What is cellular senescence.

Additional Edition: Print version: Oliveira, Paulo J. Aging San Diego : Elsevier Science & Technology,c2022 ISBN 9780128237618

Language: English

UID:

Format: 1 online resource (821 pages)

ISBN: 0-12-824131-4

Note: Front Cover -- Aging -- Copyright Page -- Contents -- List of contributors -- Foreword -- Preface -- 1 The societal burden of aging -- 1 Global aging and health determinants in a changing world -- 1.1 Introduction -- 1.2 The geographies of a global trend -- 1.2.1 Global patterns and projections -- 1.2.2 Multiscale intraregional variations of the aging process -- 1.3 Environmental health in later life -- 1.3.1 From successful aging to the role of place and inequities -- 1.3.2 How environment affects physical health in old age -- 1.3.3 The subjective experience of place: place attachment and residential normalcy -- 1.4 Global stressors in a changing world -- 1.4.1 Welfare state and neoliberalism -- 1.4.2 Climate change and health in old age -- 1.4.3 Migrations and health in old age -- 1.4.4 Discrimination as a health issue for older persons -- 1.5 Conclusion -- Acknowledgments -- References -- 2 Flagship initiatives for healthy living and active aging in Europe: the European Innovation Partnership on Active and Hea... -- 2.1 Demographic changes and aging -- 2.2 The European Innovation Partnership on Active and Healthy Ageing -- 2.2.1 European Innovation Partnership on Active and Healthy Ageing cross-cutting initiatives -- 2.3 Reference sites-case studies -- 2.3.1 Ageing@Coimbra Reference Site -- 2.3.2 The Healthy Ageing Network Northern Netherlands -- 2.3.3 Valencia region Reference Site -- 2.3.4 Andalusia Reference Site -- 2.3.5 The Lodz4Generations Reference Site -- 2.3.6 Campania Reference Site (ProMIS network) -- 2.3.7 MACVIA-France Reference Site -- 2.4 Reference Site Collaborative Network -- 2.5 Transition from Horizon 2020 to Horizon Europe-the role of IN-4-Active and Healthy Ageing -- 2.6 Future perspectives -- Acknowledgment -- References -- 3 Aging in Africa, challenges and opportunities-the particular case of Cabo Verde. , 3.1 Aging in Africa and West African Region -- 3.2 Geography and climate of Cabo Verde -- 3.3 Cabo Verde, the historical healthy islands -- 3.4 Epidemiology of slave society -- 3.5 Cabo Verde Famines -- 3.6 Cabo Verdean population genetics -- 3.7 Age pyramid of Cabo Verdean population -- 3.8 Urbanization of Cabo Verdean population -- 3.9 Aging and the emergence of a new demographic model -- 3.10 Elderly in Cabo Verde -- 3.11 Health and national health service-philosophy, structures, and budget -- 3.12 Healthy and active aging policies -- 3.13 Aging and poverty -- 3.14 Aging and gender -- 3.15 To a healthy living and active aging in Cabo Verde-the future -- References -- 4 Flagship initiatives to prevent and treat diabetes as a burden of western societies -- 4.1 Introduction -- 4.1.1 Demographics of diabetes and prediabetes -- 4.1.2 Healthcare literacy and numeracy -- 4.1.3 Food insecurity and dietary quality -- 4.1.4 Community engagement -- 4.2 Impact of research: prediabetes -- 4.2.1 The diabetes prevention program study -- 4.2.2 The finnish diabetes prevention study -- 4.3 Lifestyle interventions -- 4.3.1 The national diabetes prevention program -- 4.3.2 Exercise -- 4.3.3 Pharmacologic therapy in prediabetes -- 4.4 Impact of research: diabetes -- 4.4.1 Diabetes self-management education -- 4.5 Summary and conclusions -- References -- 5 Determining factors on active aging in Asia and Oceania: a systematic review -- 5.1 Introduction -- 5.2 Methodology -- 5.2.1 Population aging in Asia and Oceania -- 5.2.2 Data sources and search strategies -- 5.2.3 Study selection -- 5.2.4 Bias assessment -- 5.2.5 Data extraction -- 5.3 Results -- 5.3.1 Exergaming/active video games -- 5.3.2 Health wearables and activity trackers -- 5.3.3 Smartphones -- 5.3.4 Web-based programs -- 5.4 Discussion and concluding remarks -- References. , 6 Healthy living and active aging in Latin America and the Caribbean countries: biological, demographic, and epidemiologica... -- 6.1 Introduction -- 6.2 Demographic and epidemiological changes in the Latin America and the Caribbean countries -- 6.3 Age-related biological changes and diseases in the context of Latin America and the Caribbean countries -- 6.3.1 Immunosenescence and infectious diseases -- 6.3.2 Age-related intestinal microbiota changes: the role in neurodegenerative and metabolic diseases -- 6.3.3 Common age-related diseases: cancer, vascular diseases, diabetes and neurodegenerative disorders -- 6.3.3.1 Cancer -- 6.3.3.2 Cardiovascular diseases -- 6.3.3.3 Diabetes mellitus -- 6.3.3.4 Neurodegenerative disorders -- 6.4 Health and social initiatives for the promotion of healthy living and active aging -- 6.4.1 Age-friendly initiatives -- 6.4.2 Labor force participation and active aging -- 6.5 Selected health issues among older people: evidence from long-term cohorts in Latin America -- 6.6 Conclusion -- References -- 2 The biology of aging -- 7 Identification of metrics of molecular and cellular resilience in humans and animal models -- 7.1 Biomedicine is focused on disease, not health -- 7.2 Comorbidities are the prevailing characteristic of older age -- 7.3 Chronological versus physiological age -- 7.4 Linking aging to disease: geroscience principles -- 7.5 A common thread: improvement of resilience -- 7.6 Defining resilience at the molecular level -- 7.7 Measuring molecular resilience -- 7.8 We need to develop resilience metrics in animal models -- 7.9 Translation of resilience measurements to humans -- 7.10 Conclusions -- References -- 8 A metabolic and mitochondrial angle on aging -- Abbreviations -- 8.1 Aging and longevity: revisiting the evolutionary perspectives and controversies. , 8.2 Aging and longevity: challenging the traditional views for mitochondrial-derived oxidative stress -- 8.3 Changes of mitochondrial function and structure associated with aging -- 8.3.1 Oxidative phosphorylation and aging -- 8.3.2 Mitochondrial morphology and dynamics in aging -- 8.4 A metabolic angle on aging -- 8.4.1 Carbohydrate metabolism and aging -- 8.4.2 Lipid metabolism and aging -- 8.4.3 Protein metabolism and aging -- 8.4.4 Nutrient metabolism and caloric restriction -- 8.5 Oxidative stress and aging -- 8.5.1 Reactive oxygen species and their reactions -- 8.5.2 Reactive oxygen species as the cause of aging -- 8.5.3 Antioxidant defense in aging -- 8.5.4 Mitochondrial free radical theory of aging -- 8.5.5 Accumulation of reactive oxygen species-induced damage with aging -- 8.5.6 Age-related oxidative modifications of mitochondria -- 8.6 Potential strategies against aging to increase longevity -- 8.6.1 Metabolic control-related approaches -- 8.6.1.1 Caloric/dietary restriction -- 8.6.1.2 Melatonin -- 8.6.1.3 Sirtuins activators -- 8.6.1.3.1 Resveratrol showed cytotoxicity against several cancers (namely leukemia, skin and prostate cancer) -- 8.6.1.3.2 Food nutrients -- 8.6.1.3.3 Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), a diarylheptanoid derived from the rhizom... -- 8.6.1.4 Sirtuin inhibitors -- 8.6.1.5 Mitochondrial uncoupling -- 8.6.1.5.1 UCP1 was first identified in the 1970s and is the most well-known member of UCPs -- 8.6.1.5.2 UCP2, UCP3 and UCP4 -- 8.6.1.5.3 2,4-dinitrophenol (DNP) and carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP) are well-studied pharmac... -- 8.6.1.6 Physical activity -- 8.6.2 Mitochondria-related antioxidant approaches -- 8.6.2.1 What can we learn from the "eternal youth" of the naked mole rat? -- 8.6.2.2 Mitochondria-targeted antioxidants in delayed aging. , 8.6.2.2.1 MitoQ -- 8.6.2.2.2 SkQ1 -- 8.6.2.2.3 AntiOxBEN2 and AntiOxCIN4 -- 8.6.2.2.4 Other mitochondrially-targeted antioxidants -- 8.6.2.2.4.1 TEMPO and Mito-TEMPO -- 8.6.2.2.4.2 Szeto-Schiller (SS) peptides -- 8.7 Conclusions -- Acknowledgments -- References -- 9 Intercellular communication and aging -- 9.1 Importance of intercellular communication -- 9.2 The defining features of senescence -- 9.3 The mechanisms responsible for the induction of cellular senescence -- 9.4 Senescence associated secretory phenotype -- 9.5 Intercellular communication mediated by gap junctions and connexin channels -- 9.6 Intercellular communication mediated by tunneling nanotubes -- 9.7 Intercellular communication mediated by extracellular vesicles -- 9.8 Concluding remarks -- Acknowledgments -- References -- 10 Genomic instability and aging -- 10.1 Introduction -- 10.2 DNA strand breakage-induced genomic instability -- 10.3 Replication-induced genomic instability -- 10.3.1 Replication stress -- 10.3.2 Translesion DNA synthesis -- 10.3.3 Mismatch repair -- 10.4 Transcription-induced genomic instability -- 10.4.1 Transcription-coupled repair -- 10.4.2 Transcription-replication conflicts -- 10.5 Nucleotide pools -- 10.6 Mitochondrial functions in genomic integrity -- 10.6.1 Mitochondrial oxidative stress -- 10.6.2 FOXO in oxidative DNA damage response -- 10.6.3 Mitochondrial genome maintenance -- 10.6.4 Mitochondrial dysfunction -- 10.6.5 Mitophagy -- 10.7 Genomic instability in health and disease -- 10.7.1 Longevity -- 10.7.2 Progeroid syndromes -- 10.7.3 Cancer -- 10.7.4 Neurodegeneration -- 10.8 Aging interventions activating DNA repair -- 10.8.1 Exercise -- 10.8.2 Dietary restriction -- 10.8.3 Nicotinamide adenine dinucleotide -- 10.9 Conclusion and future perspectives -- Acknowledgments -- References -- 11 Telomeres and cell homeostasis in aging. , 11.1 What is cellular senescence.

Additional Edition: Print version: Oliveira, Paulo J. Aging San Diego : Elsevier Science & Technology,c2022 ISBN 9780128237618

Language: English

UID:

Format: 1 online resource (821 pages)

ISBN: 0-12-824131-4

Note: Front Cover -- Aging -- Copyright Page -- Contents -- List of contributors -- Foreword -- Preface -- 1 The societal burden of aging -- 1 Global aging and health determinants in a changing world -- 1.1 Introduction -- 1.2 The geographies of a global trend -- 1.2.1 Global patterns and projections -- 1.2.2 Multiscale intraregional variations of the aging process -- 1.3 Environmental health in later life -- 1.3.1 From successful aging to the role of place and inequities -- 1.3.2 How environment affects physical health in old age -- 1.3.3 The subjective experience of place: place attachment and residential normalcy -- 1.4 Global stressors in a changing world -- 1.4.1 Welfare state and neoliberalism -- 1.4.2 Climate change and health in old age -- 1.4.3 Migrations and health in old age -- 1.4.4 Discrimination as a health issue for older persons -- 1.5 Conclusion -- Acknowledgments -- References -- 2 Flagship initiatives for healthy living and active aging in Europe: the European Innovation Partnership on Active and Hea... -- 2.1 Demographic changes and aging -- 2.2 The European Innovation Partnership on Active and Healthy Ageing -- 2.2.1 European Innovation Partnership on Active and Healthy Ageing cross-cutting initiatives -- 2.3 Reference sites-case studies -- 2.3.1 Ageing@Coimbra Reference Site -- 2.3.2 The Healthy Ageing Network Northern Netherlands -- 2.3.3 Valencia region Reference Site -- 2.3.4 Andalusia Reference Site -- 2.3.5 The Lodz4Generations Reference Site -- 2.3.6 Campania Reference Site (ProMIS network) -- 2.3.7 MACVIA-France Reference Site -- 2.4 Reference Site Collaborative Network -- 2.5 Transition from Horizon 2020 to Horizon Europe-the role of IN-4-Active and Healthy Ageing -- 2.6 Future perspectives -- Acknowledgment -- References -- 3 Aging in Africa, challenges and opportunities-the particular case of Cabo Verde. , 3.1 Aging in Africa and West African Region -- 3.2 Geography and climate of Cabo Verde -- 3.3 Cabo Verde, the historical healthy islands -- 3.4 Epidemiology of slave society -- 3.5 Cabo Verde Famines -- 3.6 Cabo Verdean population genetics -- 3.7 Age pyramid of Cabo Verdean population -- 3.8 Urbanization of Cabo Verdean population -- 3.9 Aging and the emergence of a new demographic model -- 3.10 Elderly in Cabo Verde -- 3.11 Health and national health service-philosophy, structures, and budget -- 3.12 Healthy and active aging policies -- 3.13 Aging and poverty -- 3.14 Aging and gender -- 3.15 To a healthy living and active aging in Cabo Verde-the future -- References -- 4 Flagship initiatives to prevent and treat diabetes as a burden of western societies -- 4.1 Introduction -- 4.1.1 Demographics of diabetes and prediabetes -- 4.1.2 Healthcare literacy and numeracy -- 4.1.3 Food insecurity and dietary quality -- 4.1.4 Community engagement -- 4.2 Impact of research: prediabetes -- 4.2.1 The diabetes prevention program study -- 4.2.2 The finnish diabetes prevention study -- 4.3 Lifestyle interventions -- 4.3.1 The national diabetes prevention program -- 4.3.2 Exercise -- 4.3.3 Pharmacologic therapy in prediabetes -- 4.4 Impact of research: diabetes -- 4.4.1 Diabetes self-management education -- 4.5 Summary and conclusions -- References -- 5 Determining factors on active aging in Asia and Oceania: a systematic review -- 5.1 Introduction -- 5.2 Methodology -- 5.2.1 Population aging in Asia and Oceania -- 5.2.2 Data sources and search strategies -- 5.2.3 Study selection -- 5.2.4 Bias assessment -- 5.2.5 Data extraction -- 5.3 Results -- 5.3.1 Exergaming/active video games -- 5.3.2 Health wearables and activity trackers -- 5.3.3 Smartphones -- 5.3.4 Web-based programs -- 5.4 Discussion and concluding remarks -- References. , 6 Healthy living and active aging in Latin America and the Caribbean countries: biological, demographic, and epidemiologica... -- 6.1 Introduction -- 6.2 Demographic and epidemiological changes in the Latin America and the Caribbean countries -- 6.3 Age-related biological changes and diseases in the context of Latin America and the Caribbean countries -- 6.3.1 Immunosenescence and infectious diseases -- 6.3.2 Age-related intestinal microbiota changes: the role in neurodegenerative and metabolic diseases -- 6.3.3 Common age-related diseases: cancer, vascular diseases, diabetes and neurodegenerative disorders -- 6.3.3.1 Cancer -- 6.3.3.2 Cardiovascular diseases -- 6.3.3.3 Diabetes mellitus -- 6.3.3.4 Neurodegenerative disorders -- 6.4 Health and social initiatives for the promotion of healthy living and active aging -- 6.4.1 Age-friendly initiatives -- 6.4.2 Labor force participation and active aging -- 6.5 Selected health issues among older people: evidence from long-term cohorts in Latin America -- 6.6 Conclusion -- References -- 2 The biology of aging -- 7 Identification of metrics of molecular and cellular resilience in humans and animal models -- 7.1 Biomedicine is focused on disease, not health -- 7.2 Comorbidities are the prevailing characteristic of older age -- 7.3 Chronological versus physiological age -- 7.4 Linking aging to disease: geroscience principles -- 7.5 A common thread: improvement of resilience -- 7.6 Defining resilience at the molecular level -- 7.7 Measuring molecular resilience -- 7.8 We need to develop resilience metrics in animal models -- 7.9 Translation of resilience measurements to humans -- 7.10 Conclusions -- References -- 8 A metabolic and mitochondrial angle on aging -- Abbreviations -- 8.1 Aging and longevity: revisiting the evolutionary perspectives and controversies. , 8.2 Aging and longevity: challenging the traditional views for mitochondrial-derived oxidative stress -- 8.3 Changes of mitochondrial function and structure associated with aging -- 8.3.1 Oxidative phosphorylation and aging -- 8.3.2 Mitochondrial morphology and dynamics in aging -- 8.4 A metabolic angle on aging -- 8.4.1 Carbohydrate metabolism and aging -- 8.4.2 Lipid metabolism and aging -- 8.4.3 Protein metabolism and aging -- 8.4.4 Nutrient metabolism and caloric restriction -- 8.5 Oxidative stress and aging -- 8.5.1 Reactive oxygen species and their reactions -- 8.5.2 Reactive oxygen species as the cause of aging -- 8.5.3 Antioxidant defense in aging -- 8.5.4 Mitochondrial free radical theory of aging -- 8.5.5 Accumulation of reactive oxygen species-induced damage with aging -- 8.5.6 Age-related oxidative modifications of mitochondria -- 8.6 Potential strategies against aging to increase longevity -- 8.6.1 Metabolic control-related approaches -- 8.6.1.1 Caloric/dietary restriction -- 8.6.1.2 Melatonin -- 8.6.1.3 Sirtuins activators -- 8.6.1.3.1 Resveratrol showed cytotoxicity against several cancers (namely leukemia, skin and prostate cancer) -- 8.6.1.3.2 Food nutrients -- 8.6.1.3.3 Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), a diarylheptanoid derived from the rhizom... -- 8.6.1.4 Sirtuin inhibitors -- 8.6.1.5 Mitochondrial uncoupling -- 8.6.1.5.1 UCP1 was first identified in the 1970s and is the most well-known member of UCPs -- 8.6.1.5.2 UCP2, UCP3 and UCP4 -- 8.6.1.5.3 2,4-dinitrophenol (DNP) and carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP) are well-studied pharmac... -- 8.6.1.6 Physical activity -- 8.6.2 Mitochondria-related antioxidant approaches -- 8.6.2.1 What can we learn from the "eternal youth" of the naked mole rat? -- 8.6.2.2 Mitochondria-targeted antioxidants in delayed aging. , 8.6.2.2.1 MitoQ -- 8.6.2.2.2 SkQ1 -- 8.6.2.2.3 AntiOxBEN2 and AntiOxCIN4 -- 8.6.2.2.4 Other mitochondrially-targeted antioxidants -- 8.6.2.2.4.1 TEMPO and Mito-TEMPO -- 8.6.2.2.4.2 Szeto-Schiller (SS) peptides -- 8.7 Conclusions -- Acknowledgments -- References -- 9 Intercellular communication and aging -- 9.1 Importance of intercellular communication -- 9.2 The defining features of senescence -- 9.3 The mechanisms responsible for the induction of cellular senescence -- 9.4 Senescence associated secretory phenotype -- 9.5 Intercellular communication mediated by gap junctions and connexin channels -- 9.6 Intercellular communication mediated by tunneling nanotubes -- 9.7 Intercellular communication mediated by extracellular vesicles -- 9.8 Concluding remarks -- Acknowledgments -- References -- 10 Genomic instability and aging -- 10.1 Introduction -- 10.2 DNA strand breakage-induced genomic instability -- 10.3 Replication-induced genomic instability -- 10.3.1 Replication stress -- 10.3.2 Translesion DNA synthesis -- 10.3.3 Mismatch repair -- 10.4 Transcription-induced genomic instability -- 10.4.1 Transcription-coupled repair -- 10.4.2 Transcription-replication conflicts -- 10.5 Nucleotide pools -- 10.6 Mitochondrial functions in genomic integrity -- 10.6.1 Mitochondrial oxidative stress -- 10.6.2 FOXO in oxidative DNA damage response -- 10.6.3 Mitochondrial genome maintenance -- 10.6.4 Mitochondrial dysfunction -- 10.6.5 Mitophagy -- 10.7 Genomic instability in health and disease -- 10.7.1 Longevity -- 10.7.2 Progeroid syndromes -- 10.7.3 Cancer -- 10.7.4 Neurodegeneration -- 10.8 Aging interventions activating DNA repair -- 10.8.1 Exercise -- 10.8.2 Dietary restriction -- 10.8.3 Nicotinamide adenine dinucleotide -- 10.9 Conclusion and future perspectives -- Acknowledgments -- References -- 11 Telomeres and cell homeostasis in aging. , 11.1 What is cellular senescence.

Additional Edition: Print version: Oliveira, Paulo J. Aging San Diego : Elsevier Science & Technology,c2022 ISBN 9780128237618

Language: English