Format:
Online-Ressource (XVII, 349 p)
,
online resource
Edition:
Springer eBook Collection. Biomedical and Life Sciences
ISBN:
9781475733020
Content:
This is the first book that attempts to study the origin of cooperatvity in binding systems from the molecular point of view. The molecular approach provides a deeper insight into the mechanism of cooperativity and regulation, than the traditional phenomenological approach. This book uses the tools of statistical mechanics to present the molecular theory of cooperativity. Cooperativity is used in a variety of processes-such as loading and unloading of oxygen at relatively small pressure differences; maintaining an almost constant concentration of various compounds in living cells; and switching on and off the reading of genetic information. This book may be used as a textbook by graduate students in Chemistry, Biochemistry and Biophysics, and will also be of interest to researchers in theoretical biochemistry
Note:
1 Introducing the Fundamental Concepts2 The Binding Isotherm -- 3 Adsorption on a Single-Site Polymer with Conformational Changes Induced by the Binding Process -- 4 Two-Site Systems: Direct and Indirect Cooperativity -- 5 Three-Site Systems: Nonadditivity and Long-Range Correlations -- 6 Four-Site Systems: Hemoglobin -- 7 Large Linear Systems of Binding Sites -- 8 Regulatory Enzymes -- 9 Solvent Effects on Cooperativity -- Appendices -- A. Pair and Triplet Correlations between Events -- B. Localization of the Adsorbent Molecules and Its Effect on the Binding Isotherm -- C. Transition from Microstates to Macrostates -- D. First-Order Correction to Nonideality of the Ligand’s Reservoir -- E. Relative Slopes of Equilibrated and “Frozen-in” BIs in a Multimacrostate System -- F. Spurious Cooperativity in Single-Site Systems -- G. The Relation between the Binding Isotherm and the Titration Curve for Two-Site Systems -- H. Fitting Synthetic Data -- I. A Comment on the Nomenclature -- J. Average Binding Constants and Correlation Functions -- K. Utility Function in a Binding System -- Abbreviations Used in the Text -- References.
Additional Edition:
ISBN 9781441933362
Additional Edition:
Erscheint auch als Druck-Ausgabe ISBN 9781441933362
Additional Edition:
Erscheint auch als Druck-Ausgabe ISBN 9780306463310
Additional Edition:
Erscheint auch als Druck-Ausgabe ISBN 9781475733037
Language:
English
DOI:
10.1007/978-1-4757-3302-0
URL:
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