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Format: 1 online resource (650 pages)

ISBN: 9780323914598

Content: Recent Developments in the Synthesis and Applications of Pyridines is a comprehensive handbook for organic chemists working on innovative approaches to the synthesis of pyridines. Written by scientists in both academia and industry and designed to be a standalone reference, the book features reviews, research results and case studies on synthetic methods and applications of pyridine-based chemotypes. The book will bridge the gap between industry and academia by presenting recent innovative approaches to the synthesis of pyridines, diverse application of pyridines in drug development, heterogeneous catalysis and material science, as well as benchtop to shelf narratives of pyridine-based compounds in the industry.

Note: Front cover -- Half title -- Title -- Copyright -- Contents -- Contributors -- Preface -- Chapter 1 Role of pyridine and its privileged derivatives as anti-infective agents -- 1.1 Introduction to infectious diseases -- 1.1.1 Origin/sources of human diseases -- 1.1.2 Stages of endemic human diseases -- 1.1.3 Favorable conditions responsible for infectious diseases -- 1.1.4 Re-emergence of infectious diseases -- 1.1.5 Antimicrobial resistance -- 1.2 Anti-infective agents -- 1.3 Pyridine & -- its derivatives -- 1.4 Synthesis of pyridine derivatives -- 1.5 Bioisosteres and pyridine bioisosterism -- 1.5.1 General classification of bioisosteres -- 1.5.2 Classification of bioisosteres based on functional group -- 1.5.3 Few examples of bioisosterism in drug design are given below -- 1.6 Conclusion -- Acknowledgment -- References -- Chapter 2 Pyridine-based polymers and derivatives: Synthesis and applications -- 2.1 Introduction -- 2.1.1 History of pyridines -- 2.1.2 Ligand properties of pyridine -- 2.1.3 Transition metal complexes of pyridine -- 2.1.4 The pharmacological activity of pyridines -- 2.2 Properties of pyridine -- 2.2.1 Physical properties -- 2.2.2 Chemical properties -- 2.3 Pyridine-based polymers of heterocyclic compounds -- 2.4 Polymers of pyridine -- 2.5 Vinyl pyridine-based polymers -- 2.5.1 Polyvinyl pyridine-based polymers in light-emitting devices -- 2.5.2 Applications in metal ion adsorption -- 2.6 Applications of pyridine-based polymers -- 2.6.1 Ion-exchange resins -- 2.6.2 Photoresists -- 2.6.3 Heat-resisting materials -- 2.6.4 High-temperature electrolyte membranes -- 2.6.5 Redox polymers -- 2.6.6 Biological applications -- 2.7 Conclusions -- References -- Chapter 3 Synthetic strategies of functionalized pyridines and their therapeutic potential as multifunctional anti-Alzheimer's agents -- 3.1 Introduction. , 3.2 Synthetic strategies of pyridine based heterocycles -- 3.2.1 Synthesis of pyridine nucleus -- 3.2.2 Synthesis of 2-aminopyridines and 2-amino-3-cyano pyridines -- 3.2.3 Synthesis of pyridinium salts -- 3.2.4 Synthesis of imidazopyridines -- 3.2.5 Synthesis of pyrazolopyridines -- 3.2.6 Synthesis of furopyridines -- 3.3 Therapeutic potential of pyridine scaffolds as anti-Alzheimer's agents -- 3.3.1 Cholinesterase inhibitors -- 3.3.2 Ab aggregation inhibitors -- 3.3.3 Secretase Inhibitors -- 3.3.4 Tau aggregation inhibitors -- 3.3.5 Glycogen synthase kinase-3b inhibitors -- 3.3.6 MAO-B inhibitors -- 3.3.7 Neuroprotective agents -- 3.3.8 Adenosine A1 and A2A receptor antagonists -- 3.3.9 Selective muscarinic M1 subtype activation -- 3.3.10 Phosphodiesterase (PDE) inhibitor -- 3.3.11 Nicotinic acetylcholine receptor (nAChRs) ligands -- 3.3.12 Multitarget directed ligands (MTDLs) -- 3.4 Conclusions -- References -- Chapter 4 Design, synthesis, and in vitro anticancer activity of thiophene substituted pyridine derivatives -- 4.1 Introduction -- 4.2 Materials and characterization -- 4.2.1 Synthesis of 2-(5-bromothiophen-2-yl) pyridin-3-amine (Compound 2, Step 1) -- 4.2.2 Synthesis of 2-(5-aminothiophen-2-yl) pyridin-3-amine (Compound 3, Step 2) -- 4.2.3 Synthesis of substituted N-[2-(5-aminothiophen-2-yl) pyridin-3-yl] benzamide 4 (a-h) (Compound 4, Step 3) -- 4.2.4 Synthesis of substituted N-[5-(3-benzamidopyridin-2-yl) thiophen-2-yl] benzamide (Compound 5, Step 4) -- 4.3 Purification of the compounds -- 4.4 Analytical characterization -- 4.4.1 1H-NMR, 13CMR, and LCMS spectroscopic characterization data -- 4.4.2 Substituted N-[2-(5-aminothiophen-2-yl) pyridin-3-yl] benzamide (Compound 4 (a-h)) -- 4.4.3 Substituted N-[5-(3-benzamidopyridin-2-yl)thiophen-2-yl]benzamide (Compound 5 (a-h)) -- 4.5 In vitro anticancer activity of the compounds (5 a-h). , 4.5.1 MTT assay -- 4.6 Anticancer activity -- 4.6.1 Preparation of the cell culture and fixation -- 4.7 Biological properties -- 4.7.1 Cytotoxic activities -- 4.7.2 Molecular modeling and computational characteristics of the synthesized compounds -- 4.8 Conclusion -- Acknowledgments -- Authors Contributions -- Conflict of Interest -- Data Availability -- Funding -- References -- Chapter 5 The role of pyridine derivatives on the treatment of some complex diseases: A review -- 5.1 Introduction -- 5.2 Pyridines in general -- 5.3 Synthesis of pyridines derivatives -- 5.4 Life cycle of the malaria parasites -- 5.5 Pyridine containing drugs for malaria treatment -- 5.6 Cancer -- 5.7 Diabetes -- 5.8 Conclusion and future perspectives -- Acknowledgments -- Conflict of Interest -- References -- Chapter 6 Pyridines in Alzheimer's disease therapy: Recent trends and advancements -- 6.1 Introduction -- 6.1.1 Etiology of Alzheimer's disease-cholinergic hypothesis -- 6.1.2 β-amyloid hypothesis -- 6.1.3 BACE-1 (β-amyloid cleaving enzyme-1) role in AD -- 6.1.4 Metal chelators in AD -- 6.2 Pyridine and its role in prevention of Alzheimer's disease -- 6.2.1 Pyridine-a short synopsis on its chemistry -- 6.2.2 Role of pyridines in AChE (acetylcholine esterase) inhibition -- 6.2.3 Role of pyridine in preventing β-amyloid aggregation -- 6.2.4 Role of pyridine as BACE-1 (beta-site amyloid precursor protein cleaving enzyme) inhibitors -- 6.2.5 Role of pyridine as metal chelators -- 6.3 Synthetic routes of some pyridine derivatives used in AD -- 6.3.1 Synthesis of imidazo [1,5a] pyridine carboxylic acids derivative -- 6.3.2 2,6-disubstituted pyridine -- 6.3.3 Pyrrolo aminopyridine -- 6.3.4 Bis-1,2,4-triazole/thiosemicarbazide -- 6.4 Toxicological manifestations of pyridine -- 6.5 Molecular modeling and computational simulation of pyridine in AD. , 6.6 Pyridine in AD research (marketed drugs as well as preclinical trial drug having pyridine) -- 6.7 Conclusion -- References -- Chapter 7 Pyridine derivatives as anti-Alzheimer agents -- 7.1 Introduction -- 7.2 Target-based evaluation of pyridine derivatives as anti-Alzheimer agents -- 7.2.1 Pyridine derivatives as cholinesterase inhibitors -- 7.2.2 Pyridine derivatives as anti-β amyloid aggregates -- 7.2.3 Pyridine derivatives as BACE1 inhibitor -- 7.2.4 Pyridine derivatives as metal chelators -- 7.2.5 Pyridine derivatives for miscellaneous targets -- 7.3 Summary -- References -- Chapter 8 Role of pyridines as enzyme inhibitors in medicinal chemistry -- 8.1 General introduction -- 8.2 Marketed drugs based on pyridine nucleus -- 8.3 Synthesis of pyridine derivatives -- 8.4 Medicinal importance of pyridine -- 8.4.1 Anticancer activity -- 8.4.2 Cholinesterase inhibition activity -- 8.4.3 Antidiabetic activity -- 8.4.4 Urease inhibitory activity -- 8.4.5 Antioxidant activities -- 8.4.6 Antiinflammatory activity -- 8.4.7 Antimicrobial activity -- References -- Chapter 9 Contemporary development in the synthesis and biological applications of pyridine-based heterocyclic motifs -- 9.1 Introduction -- 9.2 Synthesis of pyridine -- 9.2.1 Hantzsch pyridine synthesis -- 9.2.2 Baeyer pyridine synthesis -- 9.2.3 Kröhnke pyridine synthesis -- 9.2.4 Katrizky pyridine synthesis -- 9.3 Green approach for the synthesis of pyridine -- 9.3.1 Ultrasound-assisted green synthesis -- 9.3.2 Microwave-assisted synthesis of pyridine -- 9.4 Synthesis and antimicrobial activity of some pyridine derivatives -- 9.5 Synthesis and antitubercular activity of some pyridine derivatives -- 9.6 Synthesis and anticancer activity of some pyridine derivatives -- 9.7 Synthesis and anti-inflammatory activity of some pyridine derivatives. , 9.8 Synthesis and antimalarial activity of some pyridine derivatives -- 9.9 Synthesis and anti-infective activity of some pyridine derivatives -- 9.10 Conclusion -- 9.11 Graphical conclusion -- Acknowledgments -- References -- Chapter 10 Synthesis of pyridine derivatives using multicomponent reactions -- 10.1 Introduction -- 10.2 Importance of pyridine and its derivatives -- 10.3 Classification of pyridines -- 10.3.1 Aromatic -- 10.3.2 Nonaromatic -- 10.4 Multicomponent reactions: its importance and green features -- 10.5 Synthesis of simple pyridine derivatives using multicomponent reactions -- 10.5.1 Ammonium acetate as a source of nitrogen to pyridine ring -- 10.5.2 Amine group as a source of nitrogen to pyridine ring -- 10.5.3 Malononitrile as a source of nitrogen to pyridine ring -- 10.5.4 Miscellaneous -- 10.6 Conclusion -- Acknowledgments -- References -- Chapter 11 Recent green synthesis of pyridines and their fused systems catalyzed by nanocatalysts -- 11.1 Introduction -- 11.2 Recent green synthesis of polysubstituted pyridines by using heterogeneous nanocatalyst systems -- 11.2.1 Multicomponent synthesis of 2-amino-3-cyano pyridines by using various heterogeneous nanocatalysts -- 11.2.2 Different heterogeneous nanocatalysts catalyzed the multicomponent synthesis of 1,4-dihydropyridines \(1,4-DHPs\) -- 11.2.3 Preparation of 2,4,6-triarylpyridine derivatives via various heterogeneous nanocatalysts -- 11.2.4 Various heterogeneous nanocatalysts catalyzed the synthesis of pyridine dicarbonitriles -- 11.2.5 Nanocatalytic activity of Cu/NCNTs catalyst for the synthesis of pyridine derivatives -- 11.3 Recent green synthesis of some selected fused heterocyclic-pyridine derivatives by using heterogeneous nanocatalyst systems -- 11.3.1 Recent green synthesis of pyrazolo[3,4-b]pyridine derivatives under various nanocatalysts. , 11.3.2 Recent green synthesis of pyridopyrimidine derivatives by using different nanocatalysts.

Additional Edition: Print version: Singh, Parvesh Recent Developments in the Synthesis and Applications of Pyridines San Diego : Elsevier,c2022 ISBN 9780323912211

Language: English