Format:
Online-Ressource (XVI, 234p. 88 illus., 45 illus. in color, digital)
ISBN:
9780387312965
Series Statement:
Fundamental Biomedical Technologies
Content:
Nanotechnology for Biology and Medicine: At the Building Block Level¡introduces the reader to current cutting-edge approaches being pursued for the design and development of nanotechnology applications to different areas of biology and medicine. It discusses the key biological challenges at the molecular and cellular levels being faced by this new field, and some of the strategies being developed to address them. The specific topics covered include the extracellular environment and design of engineered matrices, synthetic patterning methods for biological applications, molecular motors and machines, atomic force microscopy methods for measuring nanoscale features, and the use of quantum dot and carbon nanotube nanotechnologies for imaging and interfacing with neural cells. It is intended to serve as an introduction to the field, while providing in-depth coverage for the more advanced reader. ¡ Gabriel A. Silva, MSc, PhD is the Jacobs Faculty Fellows Professor of Bioengineering and an Associate Professor in the Departments of Bioengineering and Ophthalmology at the University of California, San Diego. He also is co-director of the Retina Engineering Center in the Institute of Engineering in Medicine. He is an affiliated faculty member in the Department of NanoEngineering, and a member of the Neurosciences Graduate Program, Computational Neurobiology Program, and Institute for Neural Computation. He received his Hon. B. Sc. and M. Sc. from the University of Toronto in 1996 and 1997, and a Ph. D. from the University of Illinois at Chicago in 2001. Dr. Silva completed a postdoc at Northwestern University in Chicago from 2001 to 2003,¡and ¡joined the faculty at the University of California, San Diego in 2004. Vladimir Parpura, MD, PhD holds both a medical degree, awarded from the University of Zagreb in Croatia in 1989, and a doctorate, received in Neuroscience and Zoology from Iowa State University in 1993.¡ He has held faculty appointments at the Department of Zoology and Genetics, Iowa State University and the Department of Cell Biology and Neuroscience, University of California Riverside. He is presently an Associate Professor in the Department of Neurobiology, University of Alabama Birmingham.¡
Content:
This text book will bring together a mix of both internationally known and established senior scientists along side up and coming (but already accomplished) junior scientists that have varying expertise in fundamental and applied nanotechnology to biology and medicine
Note:
Description based upon print version of record
,
Nanotechnology for Biology and Medicine; Preface; Acknowledgments; Contents; Contributors; Part I: Nanoscale Processes in Cells; Structure and Biology of the Cellular Environment: The Extracellular Matrix; 1 Introduction; 2 Composition and Architecture of ECM; 2.1 Major ECM Molecules; 2.2 ECM Architecture; 2.3 ECM-Cell Communication Pathways; 3 Role of ECM in Tissue Development and Wound Healing; 3.1 Expression of ECM in the Biological Process of Tissue Development; 3.2 ECM of Wound Healing; 4 Role of ECM in Tissue Engineering; 4.1 Microfabrication; 4.2 Nanofabrication
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4.3 Brief Survey of Nanofabrication Techniques4.4 Nanobioengineering; References; Part II: Synthesis and Characterization Approaches; Synthesis and Patterning Methods for Nanostructures Useful for Biological Applications; 1 Introduction; 1.1 Nanofabrication by Top-Down Methods; 1.1.1 Nanolithography; 1.1.2 Dry Etching Techniques; 1.1.3 Anodization; 1.2 Nanofabrication by Bottom-Up Methods; 1.2.1 Sol-Gel Processing; 1.2.2 Chemical Vapor Deposition; 1.2.3 Self-Assembly and Bio-Assisted Synthesis; 1.2.4 Laser Pyrolysis; 1.2.5 Electrochemical Deposition/Electroplating; 1.2.6 Spraying Synthesis
,
1.2.7 Atomic or Molecular Condensation1.2.8 Supercritical Fluid Synthesis; 2 Conclusions; References; Characterization of Nanoscale Biological Systems: Multimodal Atomic Force Microscopy for Nanoimaging, Nanomechanics, and Biomolecular Interactions; 1 Introduction; 2 Atomic Force Microscopy; 2.1 Operating Principle; 2.2 Spatial and Temporal Resolution; 2.3 Determination of Structural Identity; 2.4 Integration of Optical and Assay Tools; 2.5 Forces and Image Contrast in AFM; 3 High-Resolution Imaging; 3.1 Imaging Ion Channel Structure; 3.2 Imaging Cellular Processes
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3.3 Single Molecule Imaging and Manipulation3.4 Mapping Polymer Electrical Activity and Structure; 4 Nanosensing and Detection; 4.1 Force Mapping; 4.2 Cell Mechanics; 4.3 Nanoflow and Viscosity; 5 AFM in Biomaterials; 5.1 Nanoelasticity and Nanopatterning in Biomaterials; 5.2 Nanomechanics of Human Bone; 6 Nanodevices for Biological Applications; 6.1 Parallel Arrays Patch Clamping and Sensors; 6.2 Surface Chemical Array Modifications; 7 Outlook; References; Part III: Nanobiotechnology: Biologically Inspired Nanoengineering and TheirApplications; Molecular Motors and Machines; 1 Introduction
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1.1 The Bottom-Up (Supramolecular) Approach to Nanodevices1.2 Characteristics of Molecular Motors and Machines; 1.2.1 Energy Supply; 1.2.2 Other Features; 2 Natural Systems; 2.1 ATP Synthase; 2.2 Myosin; 2.3 Kinesin; 3 Artificial Systems; 3.1 Rotary Motors; 3.1.1 Rotary Motors Powered by Light Energy; 3.1.2 Toward a Chemically Driven Rotary Motor; 3.1.3 Other Systems; 3.2 Molecular Shuttles; 3.2.1 Molecular Shuttles Powered by Chemical Reactions; 3.2.2 Molecular Shuttles Powered by Electrical Signals; 3.2.3 Molecular Shuttles Powered by Light Energy; 3.3 Systems Based on Catenanes
,
3.4 Systems Based on DNA
Additional Edition:
ISBN 9780387312828
Additional Edition:
Buchausg. u.d.T. Nanotechnology for biology and medicine New York, NY : Springer, 2012 ISBN 9781461430230
Language:
English
Subjects:
Chemistry/Pharmacy
,
Medicine
Keywords:
Nanotechnologie
;
Biotechnologie
;
Medizin
DOI:
10.1007/978-0-387-31296-5
URL:
Volltext
(lizenzpflichtig)
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